Preoperative and intraoperative continuous use of dexmedetomidine on hyperalgesia after patients' remifentanil anesthesia

Yang, Miao; J, Zhang; Zhang, F; Fang, Hua

doi:10.4103/1119-3077.196063

Cited by 4 publications

(3 citation statements)

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“… 24 Furthermore, it has been demonstrated that Dex can reduce the hyperalgesia caused by remifentanil and pain stimulation, and can yield global haemodynamic stability and prevent violent injury to the throat and vocal cord. 25–27 Notably, previous reports have confirmed the efficacy of intranasal Dex as a sedative premedication to induce a favourable perioperative anxiolysis 28 and reduce emergence agitation during recovery from general anesthesia. 29 In addition, Rani et al 30 found that a single dose of Dex, administered intravenously 15 min prior to extubation, could suppress the airway reflex during recovery from general anaesthesia.…”

Section: Discussionmentioning

confidence: 92%

Effect of intratracheal dexmedetomidine administration on recovery from general anaesthesia after gynaecological laparoscopic surgery: a randomised double-blinded study

et al. 2018

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ObjectivesTo examine the efficacy of intratracheal dexmedetomidine (Dex) injection for the prevention of the laryngeal response on emergence from general anaesthesia following gynaecological laparoscopic surgery.DesignProspective, randomised, double-blinded, controlled trial.SettingA general hospital, Guangdong Province, China.ParticipantsAll patients who underwent elective laparoscopic gynaecological surgery, aged 18–60 years old, 40–80 kg in weight, American Society of Anesthesiologists class I–II were eligible. Patients were excluded if they had respiratory disease, heart disorders which might represent risk factors of potential complications of Dex such as bradycardia, heart block, coronary heart disease, uncontrolled hypertension or the long-term use of sedative drugs.InterventionPatients were randomly allocated to either receive intratracheal Dex (DT), intravenous Dex (DV) or intravenous saline (CON, n=30, respectively). In the DT and DV groups, Dex (0.5 µg/kg) was diluted and mixed in 1 or 20 mL of saline, respectively, and injected via the intratracheal or intravenous route 30 min before the completion of the surgery.Outcome measuresThe primary outcome was the coughing extent among the three groups. Secondary outcomes included awareness time, extubation time, postoperative visual analogue scale and Steward recovery score.ResultsCompared with the CON group, the extent of coughing was significantly reduced in both the DV group and the DT group. Furthermore, the mean time to awareness (13.4 (4.3) vs 8.8 (2.9), p<0.001) and the extubation time (14.3 (4.3) vs 8.4 (3.6), p<0.001) were reduced in the DT group. Patients in the DT group also experienced better early recovery quality and less pain than those in the CON group. Furthermore, intratracheal Dex administration contributed to improved stability in haemodynamics with no significant side effects.ConclusionsIntratracheal Dex administration may avoid untoward laryngeal responses for patients emerging from general anaesthesia after gynaecological laparoscopy.Trial registration numberChiCTR-IOR-15007611.

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Section: Discussionmentioning

confidence: 92%

Effect of intratracheal dexmedetomidine administration on recovery from general anaesthesia after gynaecological laparoscopic surgery: a randomised double-blinded study

et al. 2018

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“…Therefore, it is necessary to pay attention to the preoperative nursing of children with congenital heart disease, improve their negative emotions through relevant intervention measures, and improve the ISSN 2618-1584 Vol. Dexmedetomidine, a novel selective α2 adrenergic receptor agonist, has sedative, analgesic and anxiolytic effects without causing any respiratory complications [5,6] . Intranasal administration of dexmedetomidine is painless and stimulative, with high compliance of children, and can be used for preoperative administration in children [7] .…”

Section: Introductionmentioning

confidence: 99%

Effects of dexmedetomidine nasal drops-assisted audio-visual animation psychological intervention on anxiety and coordination before general anesthesia in children with congenital heart disease

2023

FMSR

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The purpose of this article is to observe the effect of dexmedetomidine nasal-assisted audiovisual animation psychological intervention on preoperative anxiety and coordination of children with congenital heart disease surgery under general anesthesia. Seventy children who underwent elective congenital heart disease surgery in our hospital from January to December 2020 were selected as the research objects, and they were divided into the control group and the study group by random number table method, 35 cases/group. Both groups were given 2μg/kg dexmedetomidine slowly instilled in the nose 30 minutes before induction of anesthesia. At the same time, the control group received routine nursing care, and the study group combined audio-visual and animated psychological intervention. The sleeping conditions of the two groups of children after 30 minutes of nasal drip were recorded. The two groups of children were compared with the modified Yale preoperative anxiety scale (mYPAS) scores at 1 day before surgery, on the day of surgery, and during induction of anesthesia, and the induction compliance checklist during induction of anesthesia (induction compliance checklist, ICC) score. Thirty minutes after nasal drip, compared with the control group, the number of children falling asleep in the study group was significantly increased, and the difference was statistically significant (P <0.05); 1 day before the operation, the mYRAS score and mYRAS score of the two groups of children were more than 40 points. Compared with the control group, the mYRAS score and the number of cases with mYRAS score ≥40 in the study group were significantly reduced on the day of surgery and during induction of anesthesia (P > 0.05). The difference was statistically significant. Significance (P < 0.05); during induction of anesthesia, compared with the control group, the number of ICC scores and ICC scores ≥ 4 in the study group were significantly lower than those in the control group (P < 0.05). The use of 2μg/kg dexmedetomidine nasal drops to assist the psychological intervention of audio-visual animation 30 minutes before surgery can significantly improve the cooperation of children and improve preoperative anxiety. It is worth promoting to improve nursing satisfaction.

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“…DOH monitors are usually used in clinical practice to guide the administration of anesthetics (2,3). However, there is no professional person to guide the infusion of remifentanil (analgesia) (4,5). The variability of DOH measures is related to the insufficient analgesic effect, and the feasibility of closed-loop control of propofol and remifentanil infusion using DOH feedback has been demonstrated (6,7).…”

Section: Introductionmentioning

confidence: 99%

Remifentanil Anesthesia on the Expression of Apoptosis-Related Proteins Bcl-2 and Bax in Rat Myocardial Cells with Ischemia-Reperfusion Injury

Wang²,

Huang

et al. 2022

Cell Mol Biol (Noisy-le-grand)

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Ischemia-reperfusion damage to the myocardium is inevitable. This study mainly explored the effect of remifentanil anesthesia on the expression of apoptosis-related proteins Bcl-2 and Bax in rat myocardial ischemia-reperfusion injury. Select 48 mice (n=6). First, prepare solutions of different concentrations of remifentanil. A model of ischemia-reperfusion cardiomyocytes was established, and 6 slices of tissue were taken from each specimen, and the positive cells were observed with an optical microscope and magnified 100 times. Bcl-2 and Bax were positive in the cytoplasm and yellowish-brown particles in the inner membrane. According to the distribution of positive cells, randomly select 3 clear fields of view from each part, count the number of positive cells in each field, and then take the average of the proportion of positive cells to get Bcl-2 or Bax protein-positive Index (PEI). Comparison of mRNA levels in each group: Compared with the R3 group, the ratio of the M, R1, and R2 groups increased, and the mRNA expression level of the M group increased almost 3 times, P<0.05. The results of the study show that remifentanil reduces the mortality of myocardial cells by regulating the appearance of Bcl-2 and Bax proteins, and has a certain protective effect on the rat heart during myocardial ischemia and reperfusion. There is no statistically significant difference in the protective effect of remifentanil on myocardial ischemia-reperfusion.

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Preoperative and intraoperative continuous use of dexmedetomidine on hyperalgesia after patients' remifentanil anesthesia

Abstract: In clinical surgery, after use of remifentanil anesthesia on patients, use of dexmedetomidine for anesthesia recovery can minimize adverse effects of drugs on patients and thus is worthy to be effectively promoted in clinics.

Cited by 4 publications

References 0 publications

Effect of intratracheal dexmedetomidine administration on recovery from general anaesthesia after gynaecological laparoscopic surgery: a randomised double-blinded study

Effect of intratracheal dexmedetomidine administration on recovery from general anaesthesia after gynaecological laparoscopic surgery: a randomised double-blinded study

Effects of dexmedetomidine nasal drops-assisted audio-visual animation psychological intervention on anxiety and coordination before general anesthesia in children with congenital heart disease

Remifentanil Anesthesia on the Expression of Apoptosis-Related Proteins Bcl-2 and Bax in Rat Myocardial Cells with Ischemia-Reperfusion Injury

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