Preoperative and intraoperative predictors of deep venous thrombosis in adult patients undergoing craniotomy for brain tumors: A Chinese single-center, retrospective study

Shi, Shuhai; Cheng, Ji; Chen, Haoliang; Zhang, Yunxin; Zhao, Ying; Wang, Baoguo

doi:10.1016/j.thromres.2020.09.005

Cited by 20 publications

(26 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have shown that obese patients with blood viscous, blood have a slow blood flow, At the same time, with an increase of BMI in obese patients, the levels of procoagulant factors such as D-dimer and fibrinogen in obese patients increased significantly, which may be associated with a higher incidence of post-operative thrombosis in obese patients [23]. In this study, a condition with BMI >30 kg/m 2 was defined as obesity.…”

Section: Discussionmentioning

confidence: 91%

A nomogram model to predict the venous thromboembolism risk after surgery in patients with gynecological tumors

Wang

Wei

Zhou

et al. 2021

Thrombosis Research

View full text Add to dashboard Cite

Venous thromboembolism (VTE) is a common post-surgical complication of gynecological malignant tumors that has serious implications on the prognosis and quality-of-life of patients. However, there exists only a few recognized specific evaluation models for the occurrence of VTE after gynecological malignant tumor surgery. We aimed to establish a nomogram model that could predict the probability of post-surgical VTE in patients with gynecological malignancies. Methods: We collected the clinical information of 673 patients who underwent surgery for gynecological malignant tumor in our hospital between January 2014 and May 2020. To reduce bias from confounding factors between groups, a 1:1 ratio propensity score matching (PSM) method was performed; meanwhile, univariate and multivariate analyses were applied to analyze the risk factors of VTE after surgeries. A nomogram prediction model was accordingly established and internally validated. Results: The predictors contained in the nomogram model included age, D-dimer value, body mass index (BMI), and surgical approach. The C-index of the model was 0.721 (95% confidence interval: 0.644-0.797), with good discrimination and calibration effect. The internally verified C-index value was 0.916. Decision curve analysis confirmed that the nomogram model was clinically useful when the incidence of thrombosis in patients was 10-75%. Conclusions: Considering the risk factors of VTE after surgery for gynecological malignant tumor, a highperformance nomogram model was established and then validated to provide individual risk assessment and guide treatment decisions.

show abstract

Section: Discussionmentioning

confidence: 91%

A nomogram model to predict the venous thromboembolism risk after surgery in patients with gynecological tumors

Wang

Wei

Zhou

et al. 2021

Thrombosis Research

View full text Add to dashboard Cite

show abstract

“…They only examined patients who exhibited symptoms or had increased D-dimer levels with ultrasound which might ignore asymptomatic patients with venous thrombosis. The incidence of postoperative DVT was found to be lower in patients with all types of brain tumors, and it ranged from 10.3 to 12.3% (3,7,12). One retrospective study reported that nine (0.54%) patients developed postoperative pulmonary embolism in 1,670 patients undergoing brain tumor surgery (7).…”

Section: Discussionmentioning

confidence: 99%

“…The incidence of postoperative DVT was found to be lower in patients with all types of brain tumors, and it ranged from 10.3 to 12.3% (3,7,12). One retrospective study reported that nine (0.54%) patients developed postoperative pulmonary embolism in 1,670 patients undergoing brain tumor surgery (7). Another retrospective study identified 107 (1.5%) postoperative pulmonary embolisms in 7,276 patients undergoing brain tumor surgery (8).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for postoperative thrombosis-related complications in patients undergoing malignant brain tumor resection: a retrospective cohort study

Liu

Zhang

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

IntroductionPatients with malignant brain tumors frequently exhibit hypercoagulation and are at a high risk of postoperative thrombosis-related complications. However, the risk factors for postoperative thrombosis-related complications remain unclear.MethodsIn this retrospective, observational study, we consecutively enrolled elective patients undergoing resection of malignant brain tumors from 26 November 2018 to 30 September 2021. The primary objective of the study was to identify risk factors for a composite of three major adverse events including postoperative lower limb deep venous thrombosis, pulmonary embolism, and cerebral ischemia.ResultsA total of 456 patients were enrolled in this study, where 112 (24.6%) patients had postoperative thrombosis-related complications, 84 (18.4%) with lower limb deep venous thrombosis, 0 (0.0%) with pulmonary embolism, and 42 (9.2%) with cerebral ischemia. In a multivariate model, age more than 60 years (OR: 3.98, 95% CI: 2.30–6.88, P < 0.001), preoperative abnormal APTT (OR: 2.81, 95% CI: 1.06–7.42, P = 0.037), operation duration longer than 5 h (OR: 2.36, 95% CI: 1.34–4.16, P = 0.003), and admission to ICU (OR: 2.49, 95% CI: 1.21–5.12, P = 0.013) were independent risk factors of the postoperative deep vein thrombosis. Intraoperative plasma transfusion (OR: 6.85, 95% CI: 2.73–17.18, P < 0.001) was associated with significantly increased odds of deep vein thrombosis.ConclusionPatients with craniocerebral malignant tumors have a high incidence of postoperative thrombosis-related complications. There is an increase in the odds of postoperative lower limb deep venous thrombosis in patients; over 60 years old, with preoperative abnormal APTT, undergoing surgeries longer than 5-h, admission to ICU, or receiving intraoperative plasma infusion. Fresh frozen plasma infusion should be used more cautiously, especially in patients with a high risk of thrombosis.

show abstract

“…Additionally, laboratory parameters and hemostatic biomarkers such as high white blood cell count, low platelet count, high soluble P-selectin levels, elevated coagulation factor VIII activity, and increased D-dimer levels are also associated VTE occurrence in brain tumors ( 32 ). A recently published study concluded that older age, body mass index, preoperative activated partial thromboplastin time, D-dimer, tumor histology, and surgery duration independently increased the risk of postoperative DVT/PE in patients with brain tumors ( 33 ).…”

Section: Discussionmentioning

confidence: 99%

Case Report: H3K27M-Mutant Glioblastoma Simultaneously Present in the Brain and Long-Segment Spinal Cord Accompanied by Acute Pulmonary Embolism

et al. 2022

View full text Add to dashboard Cite

BackgroundGlioblastoma multiforme (GBM) is a highly malignant glioma that rarely presents as an infratentorial tumor. Multicentric (MC) gliomas involve lesions widely separated in space or time, and MC gliomas involving supra- and infratentorial brain regions are rare. In most cases, the infratentorial lesion is seen after surgical manipulation or radiation therapy; it is typically located in the cerebellum or the cervical region, manifesting as metastasis originating from the brain. Besides, venous thromboembolism in brain tumors is usually seen after craniotomy.Case PresentationWe present an uncommon adult case of symptomatic H3K27M-mutant MC glioblastoma simultaneously present in the brain, fourth ventricle, and cervical and lumbar spinal cord regions accompanied by acute pulmonary artery embolism in an adult woman who had not undergone previous therapeutic interventions. We also review the literature on this interesting presentation.ConclusionOur report highlights that clinicians should be alert to the potential alarming presentation of GBM. The incidence of spinal metastasis of cerebral GBM is increasing. Patients with a prior diagnosis of GBM with or without any new onset in the spinal cord should undergo an early MRI of the spinal cord to confirm the diagnosis at an early stage. While management of GBM remains controversial, more research is needed to explore molecular features of GBM further and develop novel targeted therapies for these patients.

show abstract

Preoperative and intraoperative predictors of deep venous thrombosis in adult patients undergoing craniotomy for brain tumors: A Chinese single-center, retrospective study

Cited by 20 publications

References 33 publications

A nomogram model to predict the venous thromboembolism risk after surgery in patients with gynecological tumors

A nomogram model to predict the venous thromboembolism risk after surgery in patients with gynecological tumors

Risk factors for postoperative thrombosis-related complications in patients undergoing malignant brain tumor resection: a retrospective cohort study

Case Report: H3K27M-Mutant Glioblastoma Simultaneously Present in the Brain and Long-Segment Spinal Cord Accompanied by Acute Pulmonary Embolism

Contact Info

Product

Resources

About