Preoperative anemia, leukocytosis and thrombocytosis identify aggressive endometrial carcinomas

Njølstad, Tormund S.; Engerud, Hilde; Werner, Henrica M.J.; Salvesen, Helga B.; Trovik, Jone

doi:10.1016/j.ygyno.2013.08.032

Cited by 68 publications

(57 citation statements)

References 36 publications

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“…Patients with Stage II carcinoma had significantly higher prevalence of elevated platelet count (17.6%) than did those with Stage I carcinoma (4.5%). This is similar to the values reported by others [12][13][14][15]. For higher stage disease, the statistical analysis of thrombocytosis indicated trend (P=0.0682), but did not reach statistical significance.…”

Section: Discussionsupporting

confidence: 90%

“…The explanation for this discrepancy is not completely clear. For example, Trovik et al studied 557 patients with endometrial carcinoma in a Norwegian university hospital [15]. Seventy-five percent of these patients had Stage I carcinoma, similar to our results (75.1%).…”

Section: Discussionsupporting

confidence: 89%

“…The prognostic value of elevated platelet count in endometrial carcinoma is, however, controversial, with some studies reporting a more aggressive behavior of the cancer in patients with thrombocytosis [12][13][14][15], whereas other studies finding no correlation at all between clinical outcome and platelet count [16]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic Significance of Preoperative Thrombocytosis in Patients with Endometrial Carcinoma: Our Experience and Review of the Literature

Gu¹,

Guo²,

Szállaśi³

2016

Gynecol Obstet

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Objective: In this study, we aimed to determine the prevalence and prognostic significance of preoperative thrombocytosis (defined as platelet count ≥ 400 × 103/µl) in patients with endometrial carcinoma. Methods:This was a retrospective analysis of 389 consecutive patients diagnosed and treated at our Institution with endometrial carcinoma between 2004 and 2014. The clinicopathological characteristics of the patients (age, race, tumor type, AJCC stage, and preoperative hematological parameters) were recorded. Survival data were provided by the tumor registry. Results:The mean age of the study population was 63.7 years at diagnosis (range=33 to 97 years), and the majority (n=350, 90%) of patients were Caucasian. Most patients (n=292, 75.1%) were diagnosed with Stage I endometrial carcinoma. In addition, seventeen patients (4.4%) had Stage II, 49 patients (12.6%) had Stage III, and 9 patients (2.3%) had Stage IV disease. The most common type of cancer (n=269, 69.2%) was endometrioid adenocarcinoma, followed by mixed cell (n=16, 4.1%) and serous (n=11, 2.8%) carcinoma, respectively. A small subset (n=24, 6.2%) of the patients had thrombocytosis at diagnosis. The prevalence of thrombocytosis increased with the stage, for example from 4.5% in Stage I to 17.6% Stage II carcinoma. Interestingly, thrombocytosis appeared to be more common in African American patients (30.8%) than in Caucasians (5.4%). Statistical analysis of the survival data revealed an adverse prognostic significance for thrombocytosis: patients with thrombocytosis died at a younger age (64.3 years) than did those with normal platelet count (74.5 years). Conclusion:Thrombocytosis at diagnosis portends adverse prognostic significance in patients with endometrial carcinoma. Elevated platelet count seems to associate with higher stage disease and shorter survival. Thrombocytosis may serve as an independent prognostic factor in endometrial carcinoma or a surrogate marker for high stage disease.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Prognostic Significance of Preoperative Thrombocytosis in Patients with Endometrial Carcinoma: Our Experience and Review of the Literature

Gu¹,

Guo²,

Szállaśi³

2016

Gynecol Obstet

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“…Our knowledge about correlation between white blood cells count before surgery and prognosis of malignancy is incomplete. In one study about gastric cancer it was shown that preoperational absolute granulocyte count less than 6000 in mm3, lymphocyte count higher than 1500 in mm3 and monocyte count between 3000-9000 are the independent factors for poor prognosis and other studies were shown leukocytosis is associated with poor prognosis in lung cancer, colon cancer, endometrial cancer and cervical cancer [20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Association between Preoperational Blood Profiles and Post Operational Complications in Patients Suffering Epithelial Ovarian Cancer

Nasiri¹

2017

MOJWH

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Anemia, leukocytosis, thrombocytosis and other para neo plastic disorders have been seen in numerous malignancies especially in advanced stages. We studied the preoperational leukocytosis and thrombocytosis and clinical outcomes in patients with epithelial ovarian cancer. This study was carried out as a prospective cohort at the gynecology oncology department of Valiasr ward of Imam Hospital of Tehran university of Iran. The blood cells profile, post operational complications and overall survival have been investigated. The demographic characteristic and information concerning to specifications of ovarian cancer histopathologically, count of preoperational blood cells, post operational complications occurring after 30 days of surgery, recurrence and metastasize of disease during a year after surgery were investigated. Preoperational leukocytosis was associated with higher stage and grade and superficial and deep wound infections. Preoperational leukocytosis was associated with higher mortality rate and lower overall survival too. Further studies must pay attention to association between blood cells parameters and prediction of response to treatment option selected in epithelial ovarian cancer for choosing patients who are most profits of neo adjuvant chemotherapy.

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“…Previous studies indicated that preoperative hematologic parameters obtained from complete blood count (CBC) might serve as prognostic biomarkers for many types of cancers (Halazun et al, 2008;Smith et al, 2009;Asher et al, 2011;Raungkaewmanee et al, 2012;Allensworth et al, 2013;Ertas et al, 2013;Liu et al, 2013;Njolstad et al, 2013;Rassouli et al, 2013;Unal et al, 2013;Wang et al, 2013) CBC is an easy, inexpensive, routine preoperative investigation, so no extra cost would be incurred for its use. The preoperative platelet to lymphocyte ratio (PLR)-a novel and valuable platelet index-is known to be associated with survival outcomes of various cancers including gynecologic ones (Smith, et al, 2009;Asher et al, 2011;Raungkaewmanee, et al, 2012;Ertas, et al, 2013;Liu, et al, 2013;Rassouli, et al, 2013;Unal, et al, 2013;.…”

Section: Introductionmentioning

confidence: 99%

Elevated Preoperative Platelet to Lymphocyte Ratio Associated with Decreased Survival of Women with Ovarian Clear Cell Carcinoma

Supoken¹,

Kleebkaow²,

Chumworathayi³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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This study was conducted to establish whether the preoperative platelet to lymphocyte ratio (PLR) is predictive of survival of women with ovarian clear cell carcinoma (OCCC). A PLR > 300 was deemed elevated. Progression-free survival (PFS) was estimated using the Kaplan-Meier method. Cox proportional hazard analysis was used to determine the independent effect of PLR. Thirty-six patients were reviewed. Elevated PLRs were more commonly noted in patients with an advanced vs an early stage of disease (88.9% vs 11.1%). Women with elevated PLR carried a higher rate of disease progression during primary therapy than that those in the normal PLR group (44.4 vs 22.2%). The median PFS for patients with elevated PLR was notably worse than that for patients with normal PLR (10 vs 34 months). Despite the impact of elevated PLR on PFS, it was found to be marginally significant when controlling for commonly applied prognostic markers. It, however, trended toward significance (HR=4.76; 95%CI, 0.95-23.8). In conclusion, an elevated PLR appears to be directly associated with adverse survival rather than being a surrogate for other indicators of a poor prognosis. PLR may be a useful biomarker for predicting survival of women with OCCC and merits further large-scale studies.

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Preoperative anemia, leukocytosis and thrombocytosis identify aggressive endometrial carcinomas

Cited by 68 publications

References 36 publications

Prognostic Significance of Preoperative Thrombocytosis in Patients with Endometrial Carcinoma: Our Experience and Review of the Literature

Prognostic Significance of Preoperative Thrombocytosis in Patients with Endometrial Carcinoma: Our Experience and Review of the Literature

Association between Preoperational Blood Profiles and Post Operational Complications in Patients Suffering Epithelial Ovarian Cancer

Elevated Preoperative Platelet to Lymphocyte Ratio Associated with Decreased Survival of Women with Ovarian Clear Cell Carcinoma

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