Preoperative Assessment of Breast Cancer: Sonography Versus MR  Imaging

Hlawatsch, A.; Teifke, A.; Schmidt, Marcus; Thelen, M.

doi:10.2214/ajr.179.6.1791493

Cited by 148 publications

(67 citation statements)

References 33 publications

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“…[6][7][8] In addition, there has been debate over a possible link between increased MR use in breast cancer imaging and an increase in the number of more extensive surgeries and mastectomies being performed at some institutions. [9][10][11][12][13][14][15][16][17][18] In response to these issues, recent standardization efforts in the breast MR community have resulted in a breast MR lexicon 19,20 and a set of standardized quantities and symbols for kinetic analysis of Gd-DTPA tracer washout. 21 Review papers have discussed the variety of protocols used and given general recommendations regarding which protocol to use for a given clinical scenario.…”

Section: Introductionmentioning

confidence: 99%

An anthropomorphic phantom for quantitative evaluation of breast MRI

et al. 2011

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Purpose: In this study, the authors aim to develop a physical, tissue-mimicking phantom for quantitative evaluation of breast MRI protocols. The objective of this phantom is to address the need for improved standardization in breast MRI and provide a platform for evaluating the influence of image protocol parameters on lesion detection and discrimination. Quantitative comparisons between patient and phantom image properties are presented. Methods: The phantom is constructed using a mixture of lard and egg whites, resulting in a random structure with separate adipose-and glandular-mimicking components. T 1 and T 2 relaxation times of the lard and egg components of the phantom were estimated at 1.5 T from inversion recovery and spin-echo scans, respectively, using maximum-likelihood methods. The image structure was examined quantitatively by calculating and comparing spatial covariance matrices of phantom and patient images. A static, enhancing lesion was introduced by creating a hollow mold with stereolithography and filling it with a gadolinium-doped water solution. Results: Measured phantom relaxation values fall within 2 standard errors of human values from the literature and are reasonably stable over 9 months of testing. Comparison of the covariance matrices of phantom and patient data demonstrates that the phantom and patient data have similar image structure. Their covariance matrices are the same to within error bars in the anterior-posterior direction and to within about two error bars in the right-left direction. The signal from the phantom's adipose-mimicking material can be suppressed using active fat-suppression protocols. A static, enhancing lesion can also be included with the ability to change morphology and contrast agent concentration. Conclusions: The authors have constructed a phantom and demonstrated its ability to mimic human breast images in terms of key physical properties that are relevant to breast MRI. This phantom provides a platform for the optimization and standardization of breast MRI imaging protocols for lesion detection and characterization.

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Section: Introductionmentioning

confidence: 99%

An anthropomorphic phantom for quantitative evaluation of breast MRI

et al. 2011

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“…Current applications for breast MRI include evaluation of extent of ipsilateral malignancy [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] and screening of the contralateral breast [4,11,13,15,16,[18][19][20][21][22][23][24][25] in patients with newly diagnosed breast cancer, screening of women at high risk for breast cancer [25][26][27][28][29][30][31][32][33][34] and evaluation of patients with metastatic axillary adenopathy and an unknown primary cancer [35][36][37][38][39][40]. In 2003 the First Edition of the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) MRI lexicon was published, reflecting the significance of this tool in the breast imaging armamentarium …”

Section: Introductionmentioning

confidence: 99%

Probability of malignancy for lesions detected on breast MRI: a predictive model incorporating BI-RADS imaging features and patient characteristics

et al. 2011

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“…In case of inhomogeneous dense or extremely dense breast patterns (type III and IV according to the American College of Radiology, ACR), mammography, however, is limited in the detection of non-calcified tumors. Ultrasound can give relevant additional information in this situation [1,2]. However, contrast-enhanced MR imaging of the breast (MR mammography) has been shown to be the most sensitive imaging modality in the detection of invasive breast cancer, especially in women with dense parenchymal structures [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

The influence of preoperative MRI of the breasts on recurrence rate in patients with breast cancer

Fischer¹,

Zachariae

Baum³

et al. 2004

Eur Radiol

239

121

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Preoperative MRI of the breasts has been proven to be the most sensitive imaging modality in the detection of multifocal or multicentric tumor manifestations as well as simultaneous contralateral breast cancer. The aim of the presented retrospective study was to evaluate the benefit of preoperative MRI for patients with breast cancer. Preoperative MRI performed in 121 patients (group A) were compared to 225 patients without preoperative MRI (group B). Patients of group A underwent contrast-enhanced MR imaging of the breast using a 2D FLASH sequence technique (TR/TE/FA 336 ms/5 ms/90°; 32 slices of 4-mm thickness, time of acquisition 1:27 min, contrast agent dosage 0.1 mmol Gd-DTPA/kg bw). All patients had histologically verified breast cancer and follow-up for more than 20 months (mean time group A: 40.3 months, group B: 41 months). Both groups received the same types of systemic treatment after breast conserving surgery. The in-breast tumor recurrence rate in group A was 1/86 (1.2%) compared to 9/133 (6.8%) in group B. Contralateral carcinoma were detected within follow-up in 2/121 (1.7%) in group A vs. 9/225 (4%) in group B. All results were statistically significant (P<0.001). Based on these results, preoperative MRI of the breasts is recommended in patients with histopathologically verified breast cancer for local staging.

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Preoperative Assessment of Breast Cancer: Sonography Versus MR Imaging

Cited by 148 publications

References 33 publications

An anthropomorphic phantom for quantitative evaluation of breast MRI

An anthropomorphic phantom for quantitative evaluation of breast MRI

Probability of malignancy for lesions detected on breast MRI: a predictive model incorporating BI-RADS imaging features and patient characteristics

The influence of preoperative MRI of the breasts on recurrence rate in patients with breast cancer

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