Preoperative autologous blood donation in primary total knee arthroplasty: a single‐centre experience on 214 consecutive patients

Franchini, Massimo; Regis, Dario; Gandini, Giorgio; Corallo, Fabio; Gironcoli, Marzia De; Aprili, Giuseppe

doi:10.1111/j.1423-0410.2006.00750.x

Cited by 7 publications

(6 citation statements)

References 21 publications

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“…Hemoglobin and Hct values were checked before and after each donation and daily after the operation until discharged. [24] Reticulocyte count and iron studies were repeated at visits 1 through 5.…”

Section: Methodsmentioning

confidence: 99%

“…The most common adverse effect were mild vasovagal attack, fatigue (2 patients in erythropoietin group and 4 in placebo group), dizziness (3 and 7), nausea (3 and 4), diaphoresis (3 and 2), hyperventilation and hypotension occurring together one in each group. [24] Serious complication developed in two (2.9% of study group) after donating two units of blood each; one patient in placebo group had severe chest pain, the patient had no history of cardiac disease earlier and was diagnosed as myocardial infarction, one in erythropoietin had peripheral artery thrombosis and was not known to have had peripheral vascular disease, necessitating their removal from the study. Both donors were referred to the emergency unit for management.…”

Section: Adverse Effectsmentioning

confidence: 99%

“…In a previous study, 5.1% patients participating in the PABD programme were suspended because of onset of complications. [24] No erythropoietin antibodies were detected in 68 patients before the study or one month after its completiton. [13] Further no adverse effects associated with rHuEPO were observed in the two groups.…”

Section: Adverse Effectsmentioning

confidence: 99%

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Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy in tertiary care hospitals of Jammu

Sharma¹,

Sharma²,

Pukhta³

et al. 2013

Asian J Transfus Sci

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Introduction:To study whether the administration of recombinant human erythropoietin increases the amount of autologous blood that can be collected before orthopaedic surgery.Materials and Methods:We conducted a randomized controlled trial of recombinant human erythropoietin in 68 adults scheduled for elective orthopedic procedures. The patients received either erythropoietin 600 units/kg of body weight or placebo intravenously every 5th day prior to each phlebotomy for 21 days during which time up to 5 units of blood was collected. Patients were excluded from donation when their hematocrit values were less than 33%. All patients received iron sulphate 325mg orally 3 times daily. The mean number of units collected per patient was 4.33 ± 0.4 for erythropoietin group and 3.05± 0.71 for the placebo group.Results:The mean packed red cell volume donated by patients who received erythropoietin was 32% greater than that donated by patients who received placebo (196.3 vs. 169.4 ml, p<0.05). 68% in the placebo group and 9% of patients treated with erythropoietin were unable to donate ≥4 units. No adverse effects were attributed to erythropoietin. While participating in the study, complications developed in 2 patients one in each group necessitating their removal from the study.Conclusion:We conclude that recombinant human erythropoietin increases the ability of the patients about to undergo elective surgery to donate autologous blood units.

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Section: Methodsmentioning

confidence: 99%

Section: Adverse Effectsmentioning

confidence: 99%

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Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy in tertiary care hospitals of Jammu

Sharma¹,

Sharma²,

Pukhta³

et al. 2013

Asian J Transfus Sci

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“…In addition, allogeneic blood has been associated with increased incidence of surgical site infections [2, 18] as well as longer hospital stay [23]. The preoperative hemoglobin (Hb) level is the most important factor determining transfusion risk [10, 13]. …”

Section: Introductionmentioning

confidence: 99%

Targeted Preoperative Autologous Blood Donation in Total Knee Arthroplasty Reduces the Need for Postoperative Transfusion

Monsef

Buckup

Mayman

et al. 2013

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

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Background: Preoperative donation of autologous blood has been widely used to minimize the potential risk of allogeneic transfusions in total knee arthroplasty. A previous study from our center revealed that preoperative autologous donation reduces the allogeneic blood exposure for anemic patients but has no effect for non-anemic patients. Questions/Purposes: The current study investigates the impact of a targeted blood donation protocol on overall transfusion rates and the incidence of allogeneic blood transfusions. Methods: Prospectively, 372 patients undergoing 425 unilateral primary knee replacements were preoperatively screened by the Blood Preservation Center between 2009 and 2012. Anemic patients with a hemoglobin level less than 13.5 g/dL were advised to donate blood, while non-anemic patients did not donate. Results: Non-anemic patients who did not donate blood required allogeneic blood transfusions in 5.9% of the patients. The overall rate of allogeneic transfusion was significantly lower for anemic patients who donated autologous blood (group A, 9%) than those who did not donate (group B, 33%; p<0.001). Donating autologous blood did increase the overall transfusion rate of anemic patients to 0.84 per patient in group A compared to 0.41 per patient in group B (p<0.001). Conclusion: This investigation confirms that abandoning preoperative autologous blood donation for non-anemic patients does not increase allogeneic blood transfusion rates but significantly lowers overall transfusion rates.

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“…The problem of increased wastage of predonated RBC units that were not used should also be taken into account [4]. No general recommendation can be given regarding the use of preoperative autologous blood donation in primary total knee arthroplasty [18] and in oral and maxillofacial surgery [26,32,33].…”

Section: Preoperative Autologous Blood Donationmentioning

confidence: 99%

10 Autologous Hemotherapy

2009

Transfus Med Hemother

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Preoperative autologous blood donation in primary total knee arthroplasty: a single‐centre experience on 214 consecutive patients

Abstract: Based on the results of this study, PABD is not necessary in most patients undergoing TKA, although older female patients with low basal haemoglobin levels could benefit from a predeposit programme and/or erythropoietin support in order to reduce the risk of exposure to allogeneic blood.

Cited by 7 publications

References 21 publications

Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy in tertiary care hospitals of Jammu

Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy in tertiary care hospitals of Jammu

Targeted Preoperative Autologous Blood Donation in Total Knee Arthroplasty Reduces the Need for Postoperative Transfusion

10 Autologous Hemotherapy

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