Preoperative Blood Glucose Concentrations and Postoperative Outcomes After Elective Non-Cardiac Surgery

Perioperative catabolism

“…49 In a large cohort of 61,536 consecutive elective noncardiac surgery patients, poor preoperative glycemic control was related to adverse in-hospital outcomes and one-year mortality. 50 …”

The impact of hyperglycemia and obesity on hospitalization costs and clinical outcome in general surgery patients

“…Several retrospective and randomized controlled trials in cardio-surgical, ICU (Abdelmalak et al, 2014;American Medical Association, 2013;Bagshaw et al, 2010;Baker et al, 2006;Bardou et al, 2013;Flegal et al, 2007;Haslam & James, 2005;Hutagalung et al, 2011;Kluczynski et al, 2014;Liu et al, 2013;Moghissi et al, 2009;Schwann et al, 2001;Umpierrez et al, 2012;Utzolino et al, 2014;Valentijn et al, 2013;Yamamoto et al, 2013), and general surgery populations have reported that hyperglycemia and diabetes are associated with increased length of stay, hospital complications and mortality, and that improvement in glycemic control reduces hospital complications (Baker et al, 2006;Clement et al, 2004;McAlister et al, 2005;Pomposelli et al, 1998;Umpierrez et al, 2002), as well a significant increase in the risk for mortality within one year of surgery (Abdelmalak et al, 2014).…”

“…Among surgical patients, DM and hyperglycemia are associated with perioperative complications, length of hospital stay (LOS), resource utilization, and mortality (Kwon et al, 2013;Noordzij et al, 2007;Mraovic et al, 2010). In addition, several studies and meta-analyses have shown that the development of hyperglycemia, in patients with and without diabetes, is independently associated with complications including pneumonia, bacteremia, urinary tract infection, skin infections, pulmonary embolism, acute kidney injury, and death (Abdelmalak et al, 2014;Kwon et al, 2013;Mraovic et al, 2010).…”

Anesthesiologist’s Guide to Perioperative Glycemic Management

“…8 A Canadian study showed a direct relationship between glucose concentration and the risk for pulmonary embolism with up to a four-fold increased risk in patients undergoing total joint replacement with preoperative concentrations greater than 200 mg/dL. 11 In addition, hyperglycemia is associated with increased production and impaired scavenging of reactive oxygen species, 12 polymorphonuclear neutrophil dysfunction, 13 and decreased intracellular killing. 10 Abdelmalak and colleagues examined data on 62,000 relatively high-risk patients who underwent elective noncardiac surgery.…”