Preoperative C-reactive Protein-to-albumin Ratio Predicts Anastomotic Leakage After Esophagectomy for Thoracic Esophageal Cancer: a Single-center Retrospective Cohort Study

Sugimoto, Atsushi; Toyokawa, Takahiro; Miki, Yuichiro; Yoshii, Mami; Tajiri, Tatsuro; Sakurai, Katsunobu; Kubo, Naoshi; Tanaka, Hiroaki; Lee, Shigeru; Muguruma, Kazuya; Yashiro, Masakazu; Ohira, Masaichi

doi:10.21203/rs.3.rs-639611/v1

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…Likewise, Sugimoto et al. have reported that preoperative CAR was a significant predictor for anastomotic leakage after esophagectomy for thoracic esophageal cancer, but CRP or albumin alone was not 32 . Moreover, similar results were observed in the current study (CAR was significantly associated with severe ED, whereas CRP or albumin alone was not).…”

Section: Discussionsupporting

confidence: 90%

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Relationships of low‐grade systemic inflammation and nutritional status with erectile dysfunction severity in men on dialysis

et al. 2022

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Background Low‐grade systemic inflammation and malnutrition are frequently observed in patients on dialysis and contribute to the development of endothelial dysfunction; however, the role of these conditions in erectile dysfunction (ED) severity remains to be elucidated. Objectives To investigate the relationships of low‐grade systemic inflammation and nutritional status with ED severity in men on dialysis. Materials and methods The present study included 71 men on dialysis. The sexual health inventory for men (SHIM) was used to assess ED. Men were classified as the mild/moderate (SHIM score ≥ 8) and severe ED (SHIM score ≤ 7) groups. C‐reactive protein/albumin ratio (CAR) and Geriatric Nutritional Risk Index (GNRI) were used to evaluate low‐grade systemic inflammation and nutritional status, respectively. We performed multivariate analysis to assess the relationships of CAR and GNRI with severe ED. Results The median age of the included men was 64 years old. All men had any degree of ED with 65% having severe ED. In the univariate analyses, a significant association was observed between elevated CAR (≥0.09) and severe ED (odds ratio [OR]: 4.038, p = 0.025), whereas no significant association was observed between lower GNRI (<92) and severe ED (OR: 2.357, p = 0.109). In the multivariate analysis, an association between elevated CAR and severe ED was still significant (OR: 5.985, p = 0.010). Discussion and conclusion Low‐grade systemic inflammation was significantly associated with ED severity, whereas lower GNRI was not. These results may be helpful for further research to identify the optimal treatment for men suffering from severe ED.

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Section: Discussionsupporting

confidence: 90%

“…have reported that preoperative CAR was a significant predictor for anastomotic leakage after esophagectomy for thoracic esophageal cancer, but CRP or albumin alone was not. 32 Moreover, similar results…”

Section: Discussionsupporting

confidence: 58%

Relationships of low‐grade systemic inflammation and nutritional status with erectile dysfunction severity in men on dialysis

et al. 2022

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“…Several inflammation-based biomarkers have been used to predict the mortality and morbidity of various cancers undergoing antitumor therapies (8,9). Among these biomarkers, the albumin and neutrophil-to-lymphocyte ratio (NLR) has been extensively investigated for use in HNC (10,11).…”

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confidence: 99%

Predictive Value of Albumin and Neutrophil-to-Lymphocyte Ratio Score for Treatment Completeness and Safety Profiles in Patients With Head and Neck Cancer Receiving Definitive Concurrent Chemoradiotherapy

Hsu

Chou

Hung

et al. 2022

In Vivo

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Background/Aim: Malnutrition and inflammation are common conditions in patients with head and neck cancer (HNC). This study aimed to evaluate the predictive value of albumin combined with neutrophil-lymphocyte ratio (NLR), referring to the albumin-NLR score (ANS), in the prediction of treatment completeness and safety profiles in HNC patients receiving definitive concurrent chemoradiotherapy (CCRT). Patients and Methods: 461 consecutive HNC patients who received CCRT between 2016 and 2017 at three medical centers in Taiwan were prospectively enrolled and divided into three different groups based on their pretreatment ANS (ANS 0, high albumin and low NLR; ANS 1, low albumin or high NLR; and ANS 2, low albumin and high NLR) for treatment completeness and safety profiles comparison. Results: Overall, 46 patients (10.0%) had incomplete CCRT treatment. Patients in the ANS 2 group experienced a higher rate of incomplete CCRT (20.9%) than those in the ANS 1 (7.4%) and ANS 0 (3.5%) groups. ANS had a better discriminatory ability in predicting CCRT completeness in terms of -2 log-likelihood value, chisquare value, and c-index than the prognostic nutritional index. Patients in the ANS 2 group had significantly higher incidences of grade 3 or higher leukopenia, anemia, neutropenia, thrombocytopenia, non-neutropenic infection, and hypokalemia than those in the other two ANS groups. Conclusion: Our study showed that the ANS can accurately predict the treatment completeness of CCRT in patients with HNC and can be widely used as a simple predictor of treatment tolerance and safety profiles in patients with HNC undergoing CCRT.More than 60% of head and neck cancers (HNC) are diagnosed with locally advanced disease (1), for which radical resection does not lead to a cure. The overall 5-year survival for the advanced stages is 40%-50% and has not markedly improved in the past decades due to the frequent relapse at the primary site, distant metastases, and second primary tumors after definitive treatment (2, 3).Definitive concurrent chemoradiotherapy (CCRT) with a platinum-based regimen is currently the standard of care for patients with locally advanced HNC (4). However, grade 3 or higher grade serious adverse events (SAEs) are common in patients receiving definitive CCRT, including 41%-47% incidence of stomatitis, 37%-43% of dysphagia, 35% of odynophagia, 20%-32% of nausea or vomiting, and 15% of neutropenia (4-7). Because of the high toxicity profiles of CCRT, dose reduction of chemotherapeutic agents is common, and 6%-17% of patients fail to complete the planned CCRT (4-7), which inevitably compromises the treatment efficacy of CCRT. Therefore, avoidance of 2875

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Preoperative C-reactive Protein-to-albumin Ratio Predicts Anastomotic Leakage After Esophagectomy for Thoracic Esophageal Cancer: a Single-center Retrospective Cohort Study

Cited by 2 publications

References 20 publications

Relationships of low‐grade systemic inflammation and nutritional status with erectile dysfunction severity in men on dialysis

Relationships of low‐grade systemic inflammation and nutritional status with erectile dysfunction severity in men on dialysis

Predictive Value of Albumin and Neutrophil-to-Lymphocyte Ratio Score for Treatment Completeness and Safety Profiles in Patients With Head and Neck Cancer Receiving Definitive Concurrent Chemoradiotherapy

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