Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes

Park, B.-W.; Oh, Joosung; Kim, J.-H.; Park, S.H.; Kim, K.-S.; Kim, J.H.; Lee, K.S.

doi:10.1093/annonc/mdm538

Cited by 141 publications

(115 citation statements)

References 31 publications

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“…Previous studies have suggested that elevated serum levels of CA 15-3 and CEA preoperatively were significantly associated with tumor size, axillary node metastasis and advanced stage in the multivariate analysis; in addition, patients with elevated CA 15-3 and CEA levels exhibited a worse prognosis compared to those with normal levels of CA 15-3 and CEA, even in stage-matched analysis (6,7). Recent studies demonstrated that serial determination of CA 15-3 and CEA levels during the postoperative follow-up of breast cancer patients may be useful for early detection of preclinical recurrence or metastatic disease (8,9).…”

Section: Introductionmentioning

confidence: 83%

Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer

Geng

Liang

et al. 2014

Molecular and Clinical Oncology

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Abstract. The objective of this study was to investigate the association of serum cancer antigen and carcinoembryonic antigen (CEA) levels with clinicopathological parameters in patients diagnosed with metastatic breast cancer (MBC). We retrospectively evaluated the medical records of 284 patients diagnosed with MBC between January, 2007 and December, 2012 who fulfilled the specified criteria and the association between the levels of the two tumor marker and clinicopathological parameters was analyzed. Of the 284 patients, elevated CA 15-3 and CEA levels at initial diagnosis of recurrence were identified in 163 (57.4%) and 97 (34.2%) patients, respectively. Elevated CA 15-3 and CEA levels were significantly associated with breast cancer molecular subtypes (P<0.001 and P=0.032, respectively). Cases with luminal subtypes exhibited a higher percentage of elevated CA 15-3 and CEA levels compared to non-luminal subtypes. Elevated CA 15-3 level was correlated with bone metastasis (P=0.017). However, elevation of CEA was observed regardless of the site of metastasis. Elevation of CA 15-3 was significantly more common in MBC with multiple metastatic sites compared to MBC with a single metastasis (P=0.001). However, the incidence of elevated CEA levels did not differ between patients with a single and those with multiple metastatic sites. In conclusion, elevated CA 15-3 and CEA levels at initial diagnosis of recurrence were found to be associated with breast cancer molecular subtypes, whereas an elevated CA 15-3 level was significantly correlated with bone metastasis and an elevated CEA level was observed regardless of metastatic site. The proportion of MBC cases with elevated CA 15-3 levels differed according to the number of metastatic sites.

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Section: Introductionmentioning

confidence: 83%

Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer

Geng

Liang

et al. 2014

Molecular and Clinical Oncology

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“…The results of other authors regarding the relationship between diseases stage and the level of tumour markers are discordant. Some authors have reported more frequent occurrence of the elevated plasma levels of these tumour markers in more advance stages of that disease but others have reported lack of statistical relation between serum levels of these markers with disease stage [11]. Moreover the preoperative serum CA 15-3 level is useless for determining the histologic grade of the tumor [3].…”

Section: Discussionmentioning

confidence: 99%

The importance of preoperative elevated serum levels of CEA and CA15-3 in patients with breast cancer in predicting its histological type.

Agrawal

Jeleń²,

Rudnicki³

et al. 2010

Folia Histochem Cytobiol.

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Material and methodsTumour samples. A total of 428 patients were treated at The Department of Surgery of Wroclaw Medical University from 2005 to 2008 due to the diagnosis of breast cancer. All of them had their preoperative CA 15-3 and CEA serum concentrations measured. In all patients tumours were invasive cancers in stages I-III, and the mean age of patients was 52.5 years (range 24-83 years). All the patients in the study were women and 54.5% of them were postmenopausal.Tumour markers. Studied tumour markers levels were measured by immunoassays: Enzymum test 300 using the cutoff value of 5 ng/ml for CEA and Enzymum-test CA 15-3 using the cutoff value of 40 units/ml for CA 15.3. Intra-and interassay variations for both markers were 5% and 10%, respectively. Measurements of serum concentrations of CEA and CA 15-3 were blinded. In all cases histological slides from paraffin wax embedded material Abstract: It is not known whether in patients with breast cancer the occurrence of elevated serum tumour markers depends on its histological type. The aim of the study was to assess relationship between breast cancer histological type and the presence of increased serum levels of CEA and CA 15-3. The study population was 428 patients (all women, mean age 52.5 years), treated at The Department of Surgery of Wroclaw Medical University from 2005 to 2008 due to breast cancer. All of them had their preoperative CA 15-3 and CEA serum concentrations measured. According to the TNM system, 21% of patients were in stage I, 32.5% in stage II, 46.5% in stage III of the disease. In patients with ductal type of the cancer the elevated serum levels of CEA and CA 15-3 were observed in 48.7% and 42.2%, in lobular type in 42.4% and 52.5%, and in non-ductal/tubular types in 48.1% and 40.4% (p=N/S). Stepwise logistic regression analyses showed that ductal breast cancer is related to elevated CEA and normal CA 15-3 serum levels. The histological types of breast cancer are not significantly related to elevated serum levels of CEA and/or CA 15-3.

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“…And MUC-1, which is one of cell surface associated mucin, is aberrantly over expressed in many adenocarcinomas especially breast cancer. Therefore, higher level of CA15-3 may be associated with larger burden of occult disease and poor outcome (Park et al, 2008). Carcinoembryonic antigen (CEA) is the most widely used marker in monitoring the clinical course of patients with cancer.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Preoperative Serum Tumor Markers with Clinicopathological Features and Prognosis in Breast Cancer

Zheng¹,

Chen²,

Hu³

et al. 2012

CCO

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Background: Serologic tumor markers such as CA15-3, CEA and TPS have been used for decades to manage patients with breast cancer. Despite the frequent use of these markers, the prognostic significance of these markers remains indeterminate. Patients and methods: We retrospectively analyzed and followed up a set of 361 patients with Stages I~III breast cancer, from January 2001 to February 2011. Serumal CA15-3 and CEA levels were measured by electrochemistry (ELC), and serumal TPS was analyzed by enzyme-linked immunosorbent assays (ELISA). We explored the relationship between preoperative serologic tumor markers and clinicopathological parameters, the correlation between CA15-3, CEA or TPS levels with overall survival, and their impact on prognosis. Results: First, at the univariate analysis, higher preoperative serum CA15-3 was significantly associated with older age of onset (≥45 years, P=0.049), and the expression of TPS was related with some traditional prognostic factors such as tumor size (P=0.030), histologic grade (P=0.001) and lymph node status (P=0.008). Second, overall survival were significantly shorter among patients with elevated preoperative serum CA15-3 (P=0.000) or TPS (P=0.038) respectively. Finally, multivariate Cox regression indicated that histological grading (P=0.028), estrogen receptor(ER) expression (P=0.001) and elevated preoperative values of CA 15-3 (P=0.015) were independent prognostic factors for overall survival. Conclusions: Our study demonstrates that higher expression of preoperative serum CA15-3 or TPS was closely correlated with clinicopathology and overall survival, and CA15-3 before treatment can be used as an independent prognostic parameter in patients with primarily breast cancer. However, serum CEA had poor correlation with clinical prognostic factors.

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Preoperative CA 15-3 and CEA serum levels as predictor for breast cancer outcomes

Abstract: High preoperative CA 15-3 and CEA levels may reflect tumor burden and are associated with advanced disease and poor outcome. Measuring preoperative levels of CA 15-3 and CEA can be helpful for predicting outcomes.

Cited by 141 publications

References 31 publications

Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer

Association of CA 15-3 and CEA with clinicopathological parameters in patients with metastatic breast cancer

The importance of preoperative elevated serum levels of CEA and CA15-3 in patients with breast cancer in predicting its histological type.

Correlation of Preoperative Serum Tumor Markers with Clinicopathological Features and Prognosis in Breast Cancer

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