Preoperative chemoradiation for advanced vulvar cancer: a phase II study of the Gynecologic Oncology Group

Moore, David H.; Thomas, Gillian; Montana, Gustavo S.; Saxer, Angelika; Gallup, Donald G.; Olt, George J.

doi:10.1016/s0360-3016(98)00193-x

Cited by 295 publications

(141 citation statements)

References 33 publications

Supporting

Mentioning

130

Contrasting

Unclassified

Order By: Relevance

“…Initial clinical classification of squamous cell carcinoma of the vulva according to the UICC TNM classification of malignant tumors. (22). A total of 71 patients were treated with combined 5-FU, CDDP and irradiation to a dose of 47.6 Gy.…”

Section: Discussionmentioning

confidence: 99%

“…There were 13 (72.2%) complete responders of whom 12 remained disease-free at 2.1 years, and 5 (27.8%) partial responders of whom 2 suffered local recurrences. Finally, within a median follow-up of 4.2 years, the local recurrence rate was 16% in the GOG phase II study (22).…”

Section: N ----------------------------------------------------------mentioning

confidence: 90%

“…The median hospital stay for patients undergoing surgery was 18 days (IQR, [15][16][17][18][19][20][21][22][23][24]. Postoperative follow-up revealed necrosis in 3 (14.3%) cases, breakdown of groin wounds in 3 (14.3%), breakdown of vulvar wounds in 7 (31.8%), lymphocele in 14 (63.6%) and chronic lymphedema in 14 (63.6%).…”

Section: Tumor Classification Initial Clinical Tumor (T) and Nodal (N)mentioning

confidence: 99%

See 2 more Smart Citations

Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva

Gaudineau¹,

Weitbruch²,

Quétin³

et al. 2012

Oncology Letters

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: N ----------------------------------------------------------mentioning

confidence: 90%

Section: Tumor Classification Initial Clinical Tumor (T) and Nodal (N)mentioning

confidence: 99%

See 1 more Smart Citation

Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva

Gaudineau¹,

Weitbruch²,

Quétin³

et al. 2012

Oncology Letters

View full text Add to dashboard Cite

“…Primary chemoradiation has been shown to shrink vulvar cancers dramatically, thus permitting less extensive surgery [17][18][19] and for women with advanced illness (i.e., close/positive margins or metastatic disease in the lymph nodes), adjuvant chemoradiation is recommended. In our study, however, only about 13% of the patients diagnosed with FIGO Stages III or IV in 1999 received chemoradiation for their advanced stage disease while an additional 8-10% received non-concurrent chemotherapy plus radiation.…”

Section: Discussionmentioning

confidence: 99%

Demographic, clinical, and treatment trends among women diagnosed with vulvar cancer in the United States

Stroup

Harlan

Trimble

2008

Gynecologic Oncology

101

View full text Add to dashboard Cite

Objective-Describe the treatment and survival patterns among a population-based sample of vulvar cancer patients diagnosed in the U.S. in 1999.Methods-Cases were identified for the National Cancer Institute's Patterns of Care Study (POC) using Surveillance, Epidemiology, and End Results Program (SEER). A stratified random sample of non-Hispanic white, non-Hispanic black, and Hispanic women age 20 and older was selected from cases reported by eleven SEER registries. Analyses of the association between vulvar cancer and key demographic, clinical, and hospital characteristics by stage were performed. Cox proportional hazards was used to estimate the odds of death due to cancer. All estimates were weighted, and analyses were conducted with SUDAAN.Results-90% of cases were diagnosed with in situ or early stage invasive disease. Older patients were more likely to present at advanced stages. 25% of women with Stage III-IV vulvar cancer received chemotherapy plus radiation. We noted widespread use of radical local excision among women with Stage I/II cancer, but 46%-54% with invasive disease underwent a radical or total vulvectomy. Factors associated with cancer death were limited to age and stage. Women 75 years and older were at higher risk compared to women aged 20-49 and the risk of death increased with advancing stage.Conclusions-Vulvar cancer is diagnosed at early stages. Late stage disease is associated with a significant increase in mortality. Radical surgery was still commonly performed in 1999. Radiation was more common in women diagnosed at late stage, while the use of chemoradiation remained limited. KeywordsVulva; vulvar; cancer; patterns of care; treatment Correspondence: Antoinette M. Stroup, PhD, Utah Cancer Registry, University of Utah, 650 Komas Drive, Suite 106B, Salt Lake City, Utah 84108, Nan.Stroup@hsc.utah.edu, Tel: (801) 581-8407, Fax: (801) 581-4560. Article Précis Describe treatment and survival among a population-based sample of women in the US diagnosed in 1999 with vulvar cancer and treated in the community.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers

show abstract

“…No large randomized controlled trials have been published on the treatment of advanced vulvar cancer. Moore et al 3 reported a phase II study by the Gynecologic Oncology Group examining the use of preoperative chemoradiotherapy to avert the need for more radical surgery. In this study, 73 evaluable patients with clinical stage III-IV squamous cell vulvar carcinoma were treated with a planned split course: twicedaily concurrent cisplatin (50 mg/m 2 ) and 5-FU (1,000 mg/m 2 ) on days 1 through 4 and radiotherapy (to 47.6 Gy), followed by surgical excision of the residual primary tumor plus bilateral inguinofemoral lymph node dissection.…”

Section: Discussionmentioning

confidence: 99%

Case report from Mayo Clinic: Locally advanced Bartholin gland carcinoma

Pinn¹,

Austin²,

Schomas³

et al. 2007

Radiology and Oncology

View full text Add to dashboard Cite

Case report from Mayo Clinic: Locally advanced Bartholin gland carcinoma Tumors of the Bartholin gland are rare, comprising less than 5% of all vulvar malignancies. Treatment is largely based on that of vulvar and anal squamous cell carcinomas. A case of invasive, grade 4, poorly differentiated squamous cell carcinoma of the Bartholin gland is presented. Our patient, a 47-year-old woman, had a history significant for cervical intraepithelial neoplasia treated with conization, type 2 diabetes mellitus, and tobacco use. The course of treatment included preoperative radiotherapy plus 5-fluorouracil and cisplatin chemotherapy, followed by restaging and posterior exenteration in combination with vaginal reconstruction.

show abstract

Preoperative chemoradiation for advanced vulvar cancer: a phase II study of the Gynecologic Oncology Group

Cited by 295 publications

References 33 publications

Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva

Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva

Demographic, clinical, and treatment trends among women diagnosed with vulvar cancer in the United States

Case report from Mayo Clinic: Locally advanced Bartholin gland carcinoma

Contact Info

Product

Resources

About