Preoperative comprehensive malignancy risk estimation for thyroid nodules: Development and verification of a network-based prediction model

Shao, Guangdong; Sun, Bin; Shi, Mingming; Song, Yining; Sun, Zhonghua; Hao, Xin; Li, Longlong; Fu, Zhenpeng

doi:10.1016/j.ejso.2022.03.016

Cited by 1 publication

(2 citation statements)

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“…We also compared BRAF V600E gene detection and TI-RADS in diagnosing thyroid cancer. Previously, the specificity and sensitivity of BRAF V600E gene detection were proved to be higher than TI-RADS in thyroid cancer diagnosis [47][48][49][50][51]. Consistently, we found that the accuracy and sensitivity of BRAF V600E gene detection were 77.00% and 81.93%, respectively, significantly higher than TI-RADS.…”

Section: Discussionsupporting

confidence: 84%

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The Diagnostic Value of BRAF V600E Gene Detection Combined with DNA Ploidy Analysis in Thyroid Cancer

Cui,

Wu,

et al. 2023

Discovery Medicine

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Background: The thyroid cancer incidence has been experimenting an accelerated growth all over the world. The serine/threonine-protein kinase (BRAF) V600E gene detection or the DNA ploidy analysis has been employed in the identification of thyroid cancer type. This study aimed to evaluate the diagnostic value of the BRAF V600E gene integrated with DNA ploidy analysis in thyroid cancer. Methods: From August 2022 to May 2023, 400 individuals from the thyroid surgery outpatient department of our hospital were enrolled in this study. The participants were divided into low-risk groups (Ⅰ+Ⅱ+Ⅲ group; n = 200) and high-risk groups (Ⅳ+Ⅴ group; n = 200) based on the Thyroid Imaging Reporting and Data System (TI-RADS). A total of the patients were subjected to the DNA ploidy analysis, the BRAF V600E gene detection, or the combination of both techniques. We evaluated the diagnostic value of the above techniques and considered the postoperative pathology results as gold standard for cancer diagnosis. The negative predictive value (NPV), accuracy, specificity, sensitivity, and positive predictive value (PPV) of TI-RADS, BRAF V600E gene detection, DNA ploidy analysis, and BRAF V600E gene detection joined with DNA ploidy analysis were calculated. Results: Among 400 subjects, 238 presented thyroid cancer and 162 had benign lesions, according to the postoperative pathology results. The obtained sensitivity, specificity, accuracy, PPV, and NPV values of TI-RADS were 55.

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Section: Discussionsupporting

confidence: 84%

“…There were 238 cases of thyroid cancer while 162 turn out to be benign. The value of the thyroid cancer predictors NPV, accuracy, specificity, sensitivity, and PPV of TI-RADS were 47…”

Section: Comparison Of the Detection Methods With The Pathological Re...mentioning

confidence: 99%

The Diagnostic Value of BRAF V600E Gene Detection Combined with DNA Ploidy Analysis in Thyroid Cancer

Cui,

Wu,

et al. 2023

Discovery Medicine

View full text Add to dashboard Cite

show abstract

Preoperative comprehensive malignancy risk estimation for thyroid nodules: Development and verification of a network-based prediction model

Cited by 1 publication

References 37 publications

The Diagnostic Value of BRAF V600E Gene Detection Combined with DNA Ploidy Analysis in Thyroid Cancer

The Diagnostic Value of BRAF V600E Gene Detection Combined with DNA Ploidy Analysis in Thyroid Cancer

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