Preoperative computed tomography of the brain in non-small cell bronchogenic carcinoma.

Kormas, P; Bradshaw, John; Jeyasingham, K.

doi:10.1136/thx.47.2.106

Cited by 59 publications

(36 citation statements)

References 4 publications

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“…Two studies have identified 21-64% of brain metastases to be clinically occult prior to CT scanning [118,119]. KORMAS et al [120], found metastases in 3% of 158 pre-operative patients after negative clinical and laboratory examination. These and other studies [115] recommend CT of the brain routinely in pre-operative patients ( fig.…”

Section: Metastatic Statusmentioning

confidence: 99%

Diagnostic imaging of lung cancer

Hollings¹,

Shaw²

2002

Eur Respir J

124

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Carcinoma of the bronchus is the most common malignancy in the Western world. It is also the leading cause of cancer-related death accounting for 32% of all cancer deaths in males and 25% in females [1]. In the USA it causes more deaths than cancers of the colon, breast and prostate combined [2]. Disappointingly, in a recent UK survey of improvements in cancer survival [3], carcinoma of the bronchus showed the smallest percentage reduction in the number of deaths avoided between 1981-1990 (0.2%). This compares badly with breast (11% reduction) and melanoma (32%). The overall 5-yr survival for lung cancer diagnosed between 1986-1990 was only 5.3% (against 66% for breast and 76% for melanoma). It is on this background that the radiologist remains actively employed in the detection, diagnosis, staging and review of this common malignancy.

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Section: Metastatic Statusmentioning

confidence: 99%

Diagnostic imaging of lung cancer

Hollings¹,

Shaw²

2002

Eur Respir J

124

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“…CT of the brain has a well-documented accuracy in detecting metastatic tumors and has been described as being of value in the staging of patients who were free of neurologic symptoms [11,20,24]. Recently, magnetic resonance imaging (MRI) has also started to be used for diagnosing brain tumors, and contrast-enhanced MRI has been demonstrated to be very sensitive to small lesions and documented to have a higher sensitivity than CT [19,23].…”

Section: Discussionmentioning

confidence: 99%

Is a Diagnostic CT of the Brain Indicated in Patients with Choroidal Metastases Before Radiotherapy?

Bottke

Wiegel

Kreusel³

et al. 2005

Strahlenther Onkol

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A CCT is indicated at the diagnosis of choroidal metastases for screening of synchronous brain metastases. The incidence is about 25%, and the diagnosis of brain metastases results in a different target volume: the whole brain including the posterior parts of the eyes compared to the posterior parts of the eyes alone. Therefore, the risk of late side effects could be reduced compared with an additional later radiotherapy of the whole brain with partly overlapping fields.

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“…However there was no significant difference between the groups in survival time (25). Despite the fact that MRI is the superior test for the detection of brain metastases, CT of the brain has a well-documented accuracy in detecting metastatic lesions and has been described as being of value in the preoperative staging of patients with non-small cell lung cancer who were free of neurological symptoms (3,26,27). CT is adequate to exclude brain metastases in most patients but it can miss small lesions especially those who are located in the posterior fossa (28).…”

mentioning

confidence: 96%

“…Lung cancer is the commonest primary source of brain metastases (3). The detection of brain metastases at the time of diagnosis of lung cancer has important therapeutic complications.…”

mentioning

confidence: 99%

Staging of lung cancer. do we need a diagnostic ct of the brain after an integrated pet/ct for the detection of brain metastases?

Wever¹,

Bruyeer²,

Demaerel³

et al. 2010

Journal of the Belgian Society of Radiology

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Brain CT has been recommended in staging of patients with lung cancer because of its usefulness in the detection of metastases. Purpose of this study is to examine if a diagnostic brain CT (CT1) can be obviated when an integrated PET/CT (PET/CT ) is available. 87 consecutive patients underwent a diagnostic brain CT and a whole-body PET/CT within a period of 3 weeks to stage a known primary tumour. CT examinations were evaluated by two experienced neuroradiologists on the detection of brain lesions (benign and malignant). The results of PET/CT and CT reading were compared and both readings were compared with the clinical results. Statistical analysis was done by measuring sensitivity, specificity, PPV, NPV and accuracy. The relative accuracies were compared by a McNemar (exact) test for correlated proportions. Considering the CT1 as standard of reference, sensitivity, specificity, PPV, NPV and accuracy for the brain CT of PET/CT (CT2) and PET/CT were respectively 83%, 96%, 77%, 97%, 94% and 69%, 98%, 90%, 95%, 94%. Considering the clinical diagnosis as standard of reference these figures were for CT1, CT2 and PET/CT respectively 80%, 100%, 100%, 96%, 96% and 66%, 95%, 77%, 93%, 90% and 66%, 97%, 83%, 93%, 91%. There was no statistical difference between CT1 and CT2. The comparison of the additional CT in PET/CT with a diagnostic CT of the brain did not yield a statistical difference in the detection of brain lesions despite the inferior quality of the CT component of PET/CT. A diagnostic brain CT can be obviated when a PET/CT is available.

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Preoperative computed tomography of the brain in non-small cell bronchogenic carcinoma.

Cited by 59 publications

References 4 publications

Diagnostic imaging of lung cancer

Diagnostic imaging of lung cancer

Is a Diagnostic CT of the Brain Indicated in Patients with Choroidal Metastases Before Radiotherapy?

Staging of lung cancer. do we need a diagnostic ct of the brain after an integrated pet/ct for the detection of brain metastases?

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