Preoperative controlling nutritional status (CONUT) score predicts long-term outcomes in patients with non-B non-C hepatocellular carcinoma after curative hepatic resection

Tsunematsu, Masashi; Haruki, Koichiro; Fujiwara, Yuki; Furukawa, Kenei; Onda, Shinji; Matsumoto, Michinori; Gocho, Takeshi; Shiba, Hiroaki; Yanaga, Katsuhiko

doi:10.1007/s00423-020-01987-9

Cited by 13 publications

(14 citation statements)

References 29 publications

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“… 35 Subjective Global Assessment and the Full Nutritional Assessment are relatively complex, whereas the CONUT score provides an easier and more objective assessment of a patient’s nutritional status. 36 Thus, a higher CONUT scores could reflect not only malnutrition but also systemic inflammation and an impaired immune responses. In addition, the CONUT scores can be retrospectively studied in relation to clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor

Chang¹,

Qing²,

Ma³

et al. 2022

Journal of Immunotherapy

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In recent years, a growing number of clinical studies have shown that immune checkpoint inhibitor (ICI) can increase the remission rate and improve the prognosis of patients with esophageal cancer. The Controlling Nutritional Status (CONUT) score is a novel nutritional indicator that can predict the prognosis of certain malignancies. We retrospectively analyzed the clinical data of 69 patients with advanced esophageal cancer treated with ICI and assessed the relationship between clinicopathological factors including CONUT score, systemic immune-inflammatory index (SII), and neutrophil-to-lymphocyte ratio and the prognosis. We found the CONUT score and SII, neutrophil-to-lymphocyte ratio were an independent prognostic factor for overall survival (P<0.05). Furthermore, among patients treated with ICI, a high CONUT score was associated with a significantly worse progression-free survival (PFS) and overall survival compared with a low CONUT group. In conclusion, the CONUT can be used to predict the efficacy and prognosis of ICI therapy in patients with esophageal cancer. Our studies have shown that the CONUT score can be used as an effective indicator for the prognosis of patients with esophageal cancer receiving ICI.

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Section: Discussionmentioning

confidence: 99%

Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor

Chang¹,

Qing²,

Ma³

et al. 2022

Journal of Immunotherapy

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“…CONUT score can comprehensively reflect the nutritional status of patients and has predictive value for the prognosis of patients with various diseases. Moreover, CVD in peritoneal dialysis patients is independently correlated with all-cause death events [6][7][8]. At present, the correlation between CONUT score and cardiovascular events in MHD patients is rarely reported.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Count Score and Cardiovascular Events in Maintenance Hemodialysis Patients

Lan¹,

Yang²,

Luo³

et al. 2023

AustinJPublicHealthEpidemiol

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Purpose: Evaluating the nutritional status of patients with Maintenance Hemodialysis (MHD) based on CONUT score to explore its relationship with Cardiovascular Disease (CVD) in MHD patients. Methods: Baseline data of new-coming MHD patients hospital hemodialysis center of our hospital undergoing hemodialysis treatment for the first time from January 1, 2014 to June 30, 2020 was collected. Cardiovascular events were used as the end point. Patients were divided into three groups according to CONUT score: normal nutrition group (CONUT score 0-1), mild malnutrition group (CONUT score 2-4) and moderate to severe malnutrition group (CONUT score ≥5), and the differences of clinical data and prognosis among the three groups were compared. The risk factors of cardiovascular events in MHD patients were determined by Logistic regression analysis, and the predictive ability of the risk factors was observed with Receiver Operating Characteristic (ROC) curve. Results: A total of 424 MHD patients were included. According to the CONUT score, 31 (7.3%) patients were in the normal nutrition group, 160 (37.7%) patients in the mild malnutrition group, and 233 (55.0%) patients in the moderate to severe malnutrition group. A total of 159 patients had cardiovascular events, including 3 cases (9.7%) in the normal nutrition group, 38 cases (23.8%) in the mild malnutrition group, and 118 cases (50.6%) in the moderate to severe malnutrition group. The worse the nutritional status of patients is, the higher the incidence rate of cardiovascular events is (P<0.05). Logistic regression analysis showed that CONUT score and age were independently correlated with cardiovascular events in MHD patients (P<0.05). ROC curve analysis showed that CONUT score and age predicted cardiovascular events in MHD patients with areas under the curve were 0.683 (95% CI: 0.632-0.735, P<0.001) and 0.702 (95% CI: 0.702), respectively. 0.652 -- 0.753, P<0.001), the optimal cut-off points were 4.5 (≥5 in combination) and 68.5, the sensitivity were 74.2% and 49.1%, and the specificity was 56.6% and 81.1%, respectively. Conclusion: There is a certain correlation between CONUT score the happening of cardiovascular events and MHD patients.

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“…Studies have found that the CONUT score is a strong independent predictor of postoperative complications and longterm prognosis in colorectal cancer, 13,[22][23][24] cholangiocarcinoma, 25,26 kidney cancer, 27 esophageal cancer, 28 gastric cancer, 12,29 pancreatic cancer, 30 and liver cancer. 31,32 We established a nomogram based on the CONUT score for accurate prediction of the prognosis of patients with lung cancer. Our nomogram model was superior to the TNM staging system.…”

Section: Discussionmentioning

confidence: 99%

“…The CONUT score can also be used as a prognostic predictor for many other solid tumors. Studies have found that the CONUT score is a strong independent predictor of postoperative complications and long‐term prognosis in colorectal cancer, 13,22–24 cholangiocarcinoma, 25,26 kidney cancer, 27 esophageal cancer, 28 gastric cancer, 12,29 pancreatic cancer, 30 and liver cancer 31,32 …”

Section: Discussionmentioning

confidence: 99%

Value of the Controlling Nutritional Status score in predicting the prognosis of patients with lung cancer: A multicenter, retrospective study

Liu

Zhang

et al. 2022

J Parenter Enteral Nutr

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Background The body's immune‐nutrition status affects prognosis in patients with lung cancer. The Controlling Nutritional Status (CONUT) score is an immune‐nutrition‒related index associated with prognosis in other tumors. We aimed to assess the value of CONUT scores in predicting prognosis in patients with lung cancer. Methods In this retrospective, multicenter study, 1339 patients with lung cancer were divided into low and high CONUT score groups. The relationship between CONUT scores and overall survival (OS) was assessed by survival curves and Cox proportional hazards regression modeling. A nomogram, including CONUT scores and other clinical variables, was established. Results There were 659 (49.2%; mean age, 59.91 years) low and 680 (50.8%; mean age, 62.23 years) high CONUT score patients. OS was significantly worse in patients with high than in those with low CONUT scores (P < 0.001), even after stratification by pathological types (non–small‐cell lung cancer and small‐cell lung cancer) and Tumor, Node, Metastasis (TNM) stages. A high CONUT score independently predicted risk in patients with lung cancer (adjusted hazard ratio, 1.48; 95% CI, 1.26‒1.73; P < 0.001). The CONUT‐based nomogram could predict prognosis well (C‐index, 0.701), with better resolution and accuracy than TNM staging for predicting OS at 1, 2, and 3 years (area under the receiver operating characteristic curve, 0.735 vs 0.678, 0.742 vs 0.696, and 0.768 vs 0.743, respectively). Conclusion The CONUT score can predict prognosis in patients with lung cancer. A CONUT‐based nomogram can improve the accuracy of survival prediction in such patients.

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Preoperative controlling nutritional status (CONUT) score predicts long-term outcomes in patients with non-B non-C hepatocellular carcinoma after curative hepatic resection

Cited by 13 publications

References 29 publications

Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor

Prognostic Effect of the Controlling Nutritional Status Score in Patients With Esophageal Cancer Treated With Immune Checkpoint Inhibitor

Correlation between Count Score and Cardiovascular Events in Maintenance Hemodialysis Patients

Value of the Controlling Nutritional Status score in predicting the prognosis of patients with lung cancer: A multicenter, retrospective study

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