Preoperative Cytologic Diagnosis of Chondroid Syringoma

Siddaraju, Neelaiah; Murugan, Paari; Devadass, Clement Wilfred; Choudhury, Nilotpal; Basu, Debdatta

doi:10.1159/000325396

Cited by 4 publications

(9 citation statements)

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“…Because of its rarity, asymptomatic and subcutaneous nature, the clinical diagnosis of this condition is often missed as evidenced by the diagnoses made before histopathological examination revealed in Table 2. The differential diagnosis of such presentations include dermoid or sebaceous cyst, pilar cyst, calcifying epithelioma, or a solitary trichoepithelioma, dermatofibroma, lymph node, hamartoma, basal cell carcinoma, and seborrheic keratosis,4 with no role of non-invasive investigations like X-ray,14,15 ultrasonography,11,15,16 MRI,10 or CT scan8 in the diagnosis. FNAC and biopsy so far remains the gold standard for the diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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<p>Fine needle aspiration cytology as a preliminary diagnostic tool in chondroid syringoma: a case report and review</p>

Syed

Paudel

Rajbhandari

et al. 2019

CCID

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We report a case of chondroid syringoma (CS) in a 44-year-old male. He presented with a firm asymptomatic nodule in his left upper lip of 2-year duration. The initial clue to the diagnosis was made on fine needle aspiration cytology (FNAC), and a final diagnosis was based on histopathological examination. The case highlights the importance of FNAC in providing clues to the diagnosis of suspected cases of chondroid syringoma before performing large excisions and repair, which would require more skill and time. We have also reviewed the cytological findings of all the cases of benign CS reported until the current date.

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Section: Discussionmentioning

confidence: 99%

“…The epithelial cells arrangement is highly variable. The cells can appear singly, scattered, in groups or as sheets, attached either loosely or cohesively 12,14,17,20–22. As in our case, acini9,19 and papillary16,23 configurations have also been noted.…”

Section: Discussionmentioning

confidence: 99%

<p>Fine needle aspiration cytology as a preliminary diagnostic tool in chondroid syringoma: a case report and review</p>

Syed

Paudel

Rajbhandari

et al. 2019

CCID

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“…Malignant CS occurs more commonly in younger female patients with a predilection for the trunk and extremities, often larger than 3 cm and locally invasive . Mishra and Agarwal made a definitive diagnosis of malignant CS based on cytologic features of marked cellularity, hemorrhagic background, presence of myxoid stroma and highly pleomorphic, discohesive epithelial cells arranged in ill‐formed cords …”

Section: Discussionmentioning

confidence: 99%

Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration

Rogers

Zhou

Grunes

et al. 2016

Diagnostic Cytopathology

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Chondroid syringoma (CS) is a rare benign adnexal tumor of the skin with a resemblance to pleomorphic adenoma of salivary gland, most commonly involving the head and neck region. In the present literature, reports of the cytologic appearance of CS are scarce as it is rarely encountered by fine needle aspiration (FNA). A 67-year-old woman presented with a 1 year history of a 1 cm subcutaneous nodule in the right axilla. FNA biopsy was performed revealing an epithelial-mesenchymal biphasic neoplasm suggesting CS. Surgical excision confirmed the diagnosis and demonstrated extensive ossification, an extremely rare feature, with only seven reported cases, all located on the head. CS is a rare benign adnexal tumor of the skin, often overlooked due to its unremarkable clinical presentation. FNA is a reliable tool for the diagnosis of CS and helps guide optimal surgical management.

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“…Their histochemical and immunohistochemical (IHC) features such as stromal positivity with alcian blue and mucicarmine stains, epithelial cell expression of CK and EMA, and S-100 positivity of myoepithelial cells have also been documented both on FNAC and histology. [ 5 9 ] According to Masood and Hardy,[ 5 ] BCSs are not reliably distinguishable on cytology while Mishra and Agarwal[ 6 ] described features such as marked cellularity, hemorrhagic background, and highly pleomorphic, discohesive, epithelial cells arranged in ill-formed cords as evidence of malignancy. [ 6 ] The size and location of CS are also considered important in distinguishing BCS versus MCS.…”

Section: Discussionmentioning

confidence: 99%

“…[ 6 ] The size and location of CS are also considered important in distinguishing BCS versus MCS. [ 9 ]…”

Section: Discussionmentioning

confidence: 99%

Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma

Shobhanaa

Siddaraju

Jinkala

et al. 2016

J Cytol

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Fine-needle aspiration cytology (FNAC) features of malignant chondroid syringoma (MCS) are rarely documented. Here, we report a case of recurrent MCS, highlighting its interesting clinicopathologic features. Initially, we received cytology and histopathology slides (for review) of a 57-year-old woman who had undergone resection for an occipital MCS and later presented with recurrence. On reviewing the slides, cytology was consistent with recurrent MCS. However, tissue sections showed features of a malignant epithelial tumor with comedonecrosis and sebaceous differentiation owing to which a diagnosis of metastatic adenocarcinoma/malignant adnexal tumor was suggested. Due to an ambiguous histology, a repeat FNA was performed to perform immunocytochemistry (ICC) and oil-red O stains, which confirmed the diagnosis of MCS with sebaceous differentiation. Thus, in a situation where histology was inconclusive due to lack of representative sections, FNAC played a major role in resolving the diagnostic dilemma and facilitating an appropriate clinical management.

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Preoperative Cytologic Diagnosis of Chondroid Syringoma

Cited by 4 publications

References 4 publications

<p>Fine needle aspiration cytology as a preliminary diagnostic tool in chondroid syringoma: a case report and review</p>

<p>Fine needle aspiration cytology as a preliminary diagnostic tool in chondroid syringoma: a case report and review</p>

Chondroid syringoma of the axilla: An unusual tumor diagnosed by fine needle aspiration

Emphasizing the pivotal role of fine-needle aspiration cytology in a case of recurrent malignant chondroid syringoma

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