Preoperative elevated platelet count and thrombocytosis in gynecologic malignancies

Predictive and prognostic values of preoperative platelet parameters in patients with gynecological tumors

“…Nevertheless, a majority of studies were focused on the relationship between the malignancy and the PLT. Other platelet parameters such as PCT, MPV, P-LCR, and PDW had not been widely studied.In this study, the median (IQRs) level of PLT of patients with gynecological cancer was 261.5 (219.0-314.3) × 10 9 /L, and 15% of the patients had thrombocytosis, which was in accordance with previous literature 8,21,26. According to the existing studies, the increase in PLT is due to tumor-secreted cytokines (including interleukin (IL)-1, IL-3, IL-6, and leukemia inhibitory factors) that play a role in stimulating megakaryocyte growth and thrombopoiesis 21.…”

Preoperative Elevated Platelet Count as a Prognostic Factor in Vulvar Squamous Cell Cancer: A Mini-review

“…Thus, in reference to the body of existing literature [ 4 - 6 ], it can be deduced that preoperative thrombocytosis does not emerge as a substantial independent prognostic factor of DFS and OS in patients with vulvar SCC. Nevertheless, the interpretation of this conclusion should be done with extreme cautiousness [ 7 ]. This can be largely ascribed to the heterogeneity of reported data across studies in terms of concerns pertaining to methodological designs.…”