A pulmonary sequestration is a congenital malformation characterized by nonfunctional lung tissue with abnormal arterial systemic supply and abnormal connection to the bronchial tree. This may lead to recurrent infections rendering a surgical intervention more demanding. Because of multiple anatomic variations, it is important to obtain high quality pre-operative radiological clarification to determine the most suitable surgical approach. Although a non-surgical technique, consisting of embolization of the aberrant artery has been described, a surgical technique remains the treatment of choice in operable patients. Pre-operative embolization of the aberrant artery may reduce the risk of Haemorrhage but could cause technical challenges in a hybrid approach and therefore unforeseen per-operative stress to the surgical team. We report 2 adult patients with unusual intra-lobar sequestration with aberrant vascular rare anatomy. Both were treated by surgery. In the latter patient we performed a hybrid approach. This was complicated by per-operative coils exposure making it a technical challenge to proceed.