Preoperative endoscopic localization of colorectal cancer and tracing lymph nodes by using carbon nanoparticles in laparoscopy

Wang, Qingxuan; Chen, Endong; Cai, Yefeng; Chen, Chong; Jin, Weiwei; Zheng, Zhouci; Jin, Yi-Xiang; Chen, Yao; Zhang, Xiaohua; Li, Quan

doi:10.1186/s12957-016-0987-1

Cited by 30 publications

(46 citation statements)

References 37 publications

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“…Thus, the PLLA nanofilms could be injected inside the human body in different fluids and spaces employing a small catheter or a plastic cannula, or directly through the working channel of an endoscope and then used as nanopatches on inner organ walls. For example, nanofilms could be employed in endoscopic or laparoscopic surgery for localized thermal ablation procedures (baker 2006), as a new method for surface ferromagnetisation of tissues (Wang 2014), as surface marking of localized small lesions discovered during endoscopic examinations (Wang 2016).…”

Section: Introductionmentioning

confidence: 99%

On the injectability of free-standing magnetic nanofilms

Taccola

Fujie

Takeoka

et al. 2017

Biomed Microdevices

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Free-standing films with sub-micrometric thickness, composed of soft polymers and functional nanostructures are promising candidates for many potential applications in the biomedical field, such as reduced port abdominal surgery. In this work, freely suspended poly(L-lactic acid) nanofilms with controlled morphology embedding superparamagnetic iron oxide nanoparticles were fabricated by spin-coating deposition. The mechanical properties of magnetic nanofilms were investigated by Strain-Induced Elastic Buckling Instability for Mechanical Measurements (SIEBIMM) test. Our results show that these freely suspended nanocomposite nanofilms are highly flexible and deformable, with Young's moduli of few GPa. Since they can be handled in liquid with syringes, a quantitative description of the nanofilms behavior during the manipulation with clinically applicable needles has been also provided. These magnetic nanofilms, remotely controllable by external electromagnetic fields, have potential applications in minimally invasive surgery as injectable nanopatches on inner organs wall. Graphical abstract ᅟ.

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Section: Introductionmentioning

confidence: 99%

On the injectability of free-standing magnetic nanofilms

Taccola

Fujie

Takeoka

et al. 2017

Biomed Microdevices

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“…Particularly, Carbon nanoparticles have been widely used as a lymph node tracer in different kinds of cancers [12][13][14][15] . Staining enables surgeons to find identify the cancers, with the method successfully used for breast, gastric, and thyroid cancers [16][17][18] . However, its suitability colon cancer remains a mystery.…”

Section: Introductionmentioning

confidence: 99%

Carbon nanoparticles for identification of metastatic lymph nodes around the superior mesenteric artery in transverse colon cancer

Chi²,

Huang

et al. 2020

Preprint

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Background Accurate identification of metastatic lymph nodes around the superior mesenteric artery (SMA), with or without metastasis, is vital for surgeons when dissecting lymph nodes in patients with transverse colon cancer. In the current study, we evaluated the prospect of using carbon nanoparticles in identification of lymph nodes around SMA. Methods We recruited a total of 220 patients, with transverse colon cancer, and divided them into two groups. The first group (n=51) was carbon nanoparticle (CN) while the other (n=169) had no carbon nanoparticle (NCN) group. Intraoperative and post-operative data were compared between the groups. Results We found that 117 patients were negative for D1 lymph nodes, while 3.4% were positive for D2 lymph nodes. Additionally, 169 patients were negative for D2 lymph nodes while 10.7% of patients were positive for D3 lymph nodes. Laparoscopy easily identified black-dyed lymph nodes in the CN group. Significantly higher numbers of positive station D3 lymph nodes (0.63 ± 2.43 vs 0.29 ± 1.03, p = 0.006), number of positive station 214 nodes (0.10 ± 0.13 vs 0.08 ± 0.17, p = 0.004), the number of positive lymph nodes (2.69 ± 5.38 vs 1.90 ± 4.22, p = 0.037), and the number of total lymph nodes (39.67 ± 19.33 vs 34.50 ± 18.99, p = 0.037) were found in the CN compared to NCN group. However, we found no significant differences between CN and NCN groups with regards to the number of positive station D1 and D2 lymph nodes. Conclusions We successfully identified metastases 214 LNs around SMA in transverse colon cancer using carbon nanoparticles. These particles have potential to significantly increase the number of positive and negative lymph nodes.

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“…Recent years, different preoperative labelling methods, such as dye staining, tattooing, and metal clip, have been shown to facilitate intraoperative localization of gastrointestinal cancers [ 6 – 8 ]. However, there was a limited study on the preoperative labeling of esophageal lesion [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Preoperative endoscopic titanium clip placement facilitates intraoperative localization of early-stage esophageal cancer or severe dysplasia

et al. 2017

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BackgroundAccurate intraoperative localization of esophageal lesions is essential for successful surgical resection. We tested whether preoperative endoscopic placement of titanium clips could facilitate intraoperative localization of early-stage esophageal cancer or severe dysplasia.MethodsA prospective randomized clinical trial was performed between May 2012 and July 2014. All enrolled patients received preoperative endoscopy and esophageal endoscopic ultrasound, as well as pathological study on the biopsy specimen, to confirm early stage esophageal cancer or severe dysplasia. One day before the surgical operation, patients in the experimental group received the preoperative endoscopic titanium labeling of esophageal lesions. Then, during the surgical operation, palpitation of titanium clips was used to localize the lesions in these patients. In patients in the control group, palpitation of nodules or esophageal wall mucosal thickening, together with the consideration of the results from preoperative endoscopic and ultrasound studies, was applied to estimate the location of the esophageal lesions. Study outcomes included the proportions of patients having successful intraoperative pre-resection lesion localization, post-esophagectomy lesion visualization, negative upper surgical margin, change of surgical approaches, and positive postoperative pathological diagnosis.ResultsA total of 27 patients were enrolled into the study, with 14 in the experimental group and 13 in the control group. Compared to the patients in the control group, a higher proportion of patients in the experimental group had statistically significant successful intraoperative esophageal lesion localization (100 versus 15.3% in the experimental versus control group).ConclusionsPreoperative endoscopic titanium clip placement could facilitate intraoperative localization of early-stage esophageal cancer or severe dysplasia.Trial registrationCurrent study was registered in Chinese Clinical Trial Registry and World Health Organization International Clinical Trials Registry Platform, ChiCTR-INR-17010949. Registered 22 March 2017, retrospectively registered.

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Preoperative endoscopic localization of colorectal cancer and tracing lymph nodes by using carbon nanoparticles in laparoscopy

Cited by 30 publications

References 37 publications

On the injectability of free-standing magnetic nanofilms

On the injectability of free-standing magnetic nanofilms

Carbon nanoparticles for identification of metastatic lymph nodes around the superior mesenteric artery in transverse colon cancer

Preoperative endoscopic titanium clip placement facilitates intraoperative localization of early-stage esophageal cancer or severe dysplasia

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