Preoperative Evaluation of Hepatic Functional Reserve Using the Galactose Tolerance Test in Hepatectomized Patients

Koyama, Takashi; Miyazaki, Masaru; Udagawa, Ikuo; Koshikawa, Hisao; Iinuma, Katsuhiro; Ito, Hiroshi; Isono, Toshio; Suzuki, Hiroyuki; Koyama, Takashi; Shimoda, Tsukasa; Nakagawa, Koji; Okui, Katsuji

doi:10.3919/ringe1963.52.1746

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Relation Between Thpr and Preoperative Gatt Values1

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1996

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“…These patients usually cannot tolerate liver resection because of a severely impaired hepatic functional reserve. The evaluation of a hepatic functional reserve is important to decide on the treatment to pre vent postoperative complications in cirrhosis [12]. Many researchers have studied the rela tionship between hepatic functional mass and histological morphometric changes.…”

Section: Relation Between Thpr and Preoperative Gatt Valuesmentioning

confidence: 99%

Reduced Hepatic Functional Reserve in Cirrhosis and Obstructive Jaundice with Special Reference to Histological Morphometric Analysis and Galactose Elimination Capacity

et al. 1996

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To evaluate liver dysfunction in patients with obstructive jaundice (OJ), morphological and functional hepatic mass was analyzed in comparison with cirrhosis (LC). Total hepatic parenchymal ratio (THPR) was estimated by morphometric analysis and hepatic functional mass by galactose tolerance test (GaTT) in 30 patients who underwent hepatectomy. The value of GaTT in patients with LC was remarkably depressed compared to those with normal liver function (p < 0.001). It was also depressed in OJ (p < 0.05 vs. normal liver), but less than in LC (p < 0.05). However, THPR decreased only in LC (p < 0.05 vs. either normal liver or OJ). A significant correlation between the value of GaTT and THPR was revealed in patients with LC, but not in OJ. These results suggested that liver dysfunction in OJ was independent of the decreased number of hepatocytes, differing from LC.

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Section: Relation Between Thpr and Preoperative Gatt Valuesmentioning

confidence: 99%