Preoperative evaluation of malignant liver tumors: comparison of unenhanced and SPIO (Resovist)-enhanced MR imaging with biphasic CTAP and intraoperative US

Vogl, Thomas J.; Schwarz, W.; Blume, Stefan; Pietsch, Michael; Shamsi, Kohkan; Franz, M. A.; Lobeck, H.; Balzer, Thomas; Tredici, Kelly Del; Neuhaus, P.; Félix, R.; Hammerstingl, Renate

doi:10.1007/s00330-002-1677-7

Cited by 126 publications

(34 citation statements)

References 39 publications

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“…The magnetic hysteresis curve of Mag@SiO2 nanoparticles obtained by SQUID measurement is shown in Figure 3, which was found to have no coercive fields, thus confirming their superparamagnetic nature. Mag@SiO2 nanoparticles were found to possess a relatively high mass magnetization value of 74.4 emu/g, which is comparable to the previously reported mass magnetisation values of 72.9 emu/g for commercially available Resovist iron oxide particles [35].…”

Section: Resultssupporting

confidence: 85%

“…Additionally, the different geometrical arrangement of nanoparticles in suspensions and in cells, and possibly antiferromagnetic coupling as a result of clustering within the sub-cellular compartments may play some role in reducing relaxivity values after cellular uptake [28], [48]. Notably, in contrast to relaxivity values of 230–269 l/mmol/s observed for Mag@SiO2 nanoparticles in this study, commercial Resovist based nanoparticles have been reported with lower values of 151 l/mmol/s [35]. The observed relaxivity value of Mag@SiO2 nanoparticles prepared in this study is also relatively higher than those reported for undoped magnetite particles (218 l/mmol/s) in recent detailed studies [24].…”

Section: Resultsmentioning

confidence: 56%

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Quasi-Cubic Magnetite/Silica Core-Shell Nanoparticles as Enhanced MRI Contrast Agents for Cancer Imaging

et al. 2011

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Development of magnetic resonance imaging (MRI) contrast agents that can be readily applied for imaging of biological tissues under clinical settings is a challenging task. This is predominantly due to the expectation of an ideal MR agent being able to be synthesized in large quantities, possessing longer shelf life, reasonable biocompatibility, tolerance against its aggregation in biological fluids, and high relaxivity, resulting in better contrast during biological imaging. Although a repertoire of reports address various aforementioned issues, the previously reported results are far from optimal, which necessitates further efforts in this area. In this study, we demonstrate facile large-scale synthesis of sub-100 nm quasi-cubic magnetite and magnetite/silica core-shell (Mag@SiO2) nanoparticles and their applicability as a biocompatible T2 contrast agent for MRI of biological tissues. Our study suggests that silica-coated magnetite nanoparticles reported in this study can potentially act as improved MR contrast agents by addressing a number of aforementioned issues, including longer shelf life and stability in biological fluids. Additionally, our in vitro and in vivo studies clearly demonstrate the importance of silica coating towards improved applicability of T2 contrast agents for cancer imaging.

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Section: Resultssupporting

confidence: 85%

Section: Resultsmentioning

confidence: 56%

Quasi-Cubic Magnetite/Silica Core-Shell Nanoparticles as Enhanced MRI Contrast Agents for Cancer Imaging

et al. 2011

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“…A variety of radiologic imaging is currently available for the clinical use in these cases 3. CT arterioportography has been widely used in the differential diagnosis, however, this technique is invasive and the results are not always reliable 4. Over the years, the success rates have increased with the development of new MR contrast agents such as superparamagnetic iron oxide (SPIO) 3.…”

Section: Introductionmentioning

confidence: 99%

Diffusion weighted MR imaging in the differential diagnosis of haemangiomas and metastases of the liver

İnan¹,

Kilinc²,

Sarısoy³

et al. 2010

Radiology and Oncology

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BackgroundThe purpose of the study was to evaluate the value of diffusion-weighted imaging in the differential diagnosis of haemangiomas from metastases of the liver.Patients and methods.We analyzed 69 lesions in 38 patients (33 haemangiomas; 36 metastases) in the retrospective study. Diffusion-weighted imaging was performed using a breath-hold single-shot echo-planar spin echo sequence with three b factors (0, 500 and 1000 sec/mm2), and apparent diffusion coefficients (ADCs) were calculated. For the quantitative evaluation, signal intensity of the lesions, lesion-to-liver signal intensity ratios, ADC of the lesions, and lesion-to-liver ADC ratios were compared between the groups. The statistical significance was determined by student’s-t test.ResultsWith the b factor 500 sec/mm2, no statistical significance was achieved (p>0.05). With the b factor of 1000 sec/mm2, both the signal intensity and lesion-to-liver signal intensity ratio of the metastases were significantly higher than those for haemangiomas (p<0.001). The cut-off value at 2.6 yielded a sensitivity of 86% and a specificity of 82% for the lesion-to-liver signal intensity ratio. The ADC, and lesion-to-liver ADC ratio of the metastases were significantly lower than those of haemangiomas (p<0.001). With cut-off value of 1.7, ADC ratio had a sensitivity of 88% and a specificity of 72% for ADC lesion/liver.ConclusionsDiffusion-weighted imaging with high b value may help in the differential diagnosis of metastases from haemangiomas of the liver.

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“…Intra-operative ultrasound has emerged as an important tool for accurately staging metastatic liver disease, having greater sensitivity and specificity than any commonly used pre-operative radiological examination (29)(30)(31)(32)(33). Contrast-enhanced IOUS has been shown to be significantly more sensitive than IOUS and to reduce the risk of underestimating the disease stage and thus enhance the cure rate of the surgical treatment (34,35).…”

Section: Discussionmentioning

confidence: 99%

Intra‐operative ultrasound for detection of liver metastases from colorectal cancer

Mazzoni

Napoli

Mandetta

et al. 2007

Liver International

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Preoperative evaluation of malignant liver tumors: comparison of unenhanced and SPIO (Resovist)-enhanced MR imaging with biphasic CTAP and intraoperative US

Cited by 126 publications

References 39 publications

Quasi-Cubic Magnetite/Silica Core-Shell Nanoparticles as Enhanced MRI Contrast Agents for Cancer Imaging

Quasi-Cubic Magnetite/Silica Core-Shell Nanoparticles as Enhanced MRI Contrast Agents for Cancer Imaging

Diffusion weighted MR imaging in the differential diagnosis of haemangiomas and metastases of the liver

Intra‐operative ultrasound for detection of liver metastases from colorectal cancer

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