2007
DOI: 10.1111/j.1432-2277.2007.00496.x
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Preoperative evaluation of microencapsulated human parathyroid tissue aids selection of the optimal bioartificial graft for human parathyroid allotransplantation

Abstract: Summary Allotransplantation of microencapsulated parathyroid tissue is a promising approach to the treatment of permanent hypoparathyroidism. Preoperative assessment of the quality of microencapsulated parathyroid tissue could facilitate selection of the optimal bioartifical graft for human parathyroid allotransplantation. Parathyroid tissue from patients with secondary hyperparathyroidism (n = 15) was processed mechanically or enzymatically (collagenase type II). Tissue particles and single cells/cell cluster… Show more

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Cited by 16 publications
(8 citation statements)
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“…The use of cultured human parathyroid cells is an essential technique for allo-and xeno-transplantation because it provides better engraftment of parathyroid cells by means of better revascularization and a decrease in the expression of the major histocompatibility complex on parathyroid cells (2,19,20). To overcome organ rejection in parathyroid allotransplantation, a number of methods have been proposed, such as short-term immunosuppression and immune-alteration by depletion of passenger leukocytes or preoperative organ culture but unfortunately, those approaches resulted in prolonged but insufficient graft function (21)(22)(23).…”
Section: Discussionmentioning
confidence: 99%
“…The use of cultured human parathyroid cells is an essential technique for allo-and xeno-transplantation because it provides better engraftment of parathyroid cells by means of better revascularization and a decrease in the expression of the major histocompatibility complex on parathyroid cells (2,19,20). To overcome organ rejection in parathyroid allotransplantation, a number of methods have been proposed, such as short-term immunosuppression and immune-alteration by depletion of passenger leukocytes or preoperative organ culture but unfortunately, those approaches resulted in prolonged but insufficient graft function (21)(22)(23).…”
Section: Discussionmentioning
confidence: 99%
“…The techniques described in the literature clearly require advanced laboratory equipment and several staff. 13,17,19,20 A significant advantage of PA-t is its applicability without using immunosuppressant (as in corneal allotransplant) because parathyroid cells do not express MHC class II antigens, which are responsible for graft rejection, and express a small amount of MHC class I antigens. 21 Various techniques have been used to perform PAt without immunosuppression.…”
Section: Discussionmentioning
confidence: 99%
“…Several types of artificial materials have been tested to obtain a good outcome for the microencapsulation technique, such as sodium polystyrene, chitosan, PLGA-alginate, poly-L-ornithine, polyethylene glycol, collagen, cellulose, polylisine, photosensitive poly (L-lysine), mitogenic or amitogenic alginate, polyvinylidene difluoride, and calcium chloride [ 76 , 77 , 78 , 79 , 80 , 94 , 95 , 96 , 97 , 98 , 99 ]. Among all these materials, ultrapure alginate was proven to be the best-qualified material for human studies, not only for the biocompatibility of the material, but also because it prevents rejection correlated to the activation of the host immune system.…”
Section: Transplantation Technologies and Hypoptmentioning
confidence: 99%
“…This technique has been improved through numerous studies since the late 1980s [ 78 ]. In that period, the question was to understand how cell microencapsulation could be done to preserve cell viability and endocrine functionality [ 77 , 78 , 79 , 80 , 94 , 95 , 96 ].…”
Section: Transplantation Technologies and Hypoptmentioning
confidence: 99%