Preoperative evaluation of residual liver function for extended hepatic resection with positron emission tomography and -[methyl-C] methionine

Ochiai, Kazunori; Asano, Tomohiko; Okazumi, Shinichi; Enomoto, Kazuo; Takayama, Wataru; Shinohara, Yasushi; Miura, Fumihiko; Isono, Kaichi

doi:10.1016/s0928-4346(97)00371-x

Cited by 5 publications

(7 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, [11C]Met PET experimental studies of liver function have been reported by Ishiwata et al We have shown that, in humans, [11C]Met PET is a useful method for evaluating liver function, by assessing amino acid metabolism 23,24. Further, we have established a new index of residual liver functional reserve FVI 7. This indicator is calculated from residual volume, determined by computed tomography (CT) and the uptake of l ‐[methyl‐11c] methionine [expressed by the differential absorption ratio (DAR) with PET], in the residual liver.…”

Section: Discussionmentioning

confidence: 99%

“…Computed tomographic volumetric10 measurements of the residual liver were calculated, and residual liver functional reserve was quantified as the functional volume index (FVI)7 according to the formula: FVI = DAR in residual liver × residual liver volume (cm 3 )/body surface area (m 2 ) DAR, liver volume, and FVI in residual liver were each estimated before and after PTPE.…”

Section: Methodsmentioning

confidence: 99%

“…In this study, we attempted to quantify the residual liver functional reserve of nonembolized liver as the functional volume index (FVI),7 using l ‐[methyl‐11c] methionine positron emission tomography (PET) and computed tomography (CT) before and after PTPE.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of residual liver functional reserve after portal embolization with positron emission tomography usingl-[methyl-11C] methionine and computed tomography

Ochiai

Asano

Okazumi

et al. 1997

J Hep Bil Pancr Surg

View full text Add to dashboard Cite

Hepatic functional reserve after portal embolization was assessed in eight patients according to the functional volume index (FVI), a new index obtained using positron emission tomography (PET) with L-[methyl-l*C] methionine. FVI in residual liver was 1744-5252 (mean, 3441) (normal range, 3106-6211) before percutaneous transhepatic portal embolization (PTPE) and 2457-6906 (mean, 4590) after PTPE. FVI exceeded 4000 in five patients and did not reach 4000 in three patients after PTPE. Two patients with FVI values of more than 4000 survived after hepatectomy and one with FVI under 4000 died of liver failure. FVI is a useful criterion for determining indications for PTPE; a value exceeding 4000 is needed before major hepatectomy can be safely performed after PTPE.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of residual liver functional reserve after portal embolization with positron emission tomography usingl-[methyl-11C] methionine and computed tomography

Ochiai

Asano

Okazumi

et al. 1997

J Hep Bil Pancr Surg

View full text Add to dashboard Cite

show abstract

“…Methionine is an essential amino acid, and is needed for protein synthesis, transmethylation reactions, and polyamine synthesis; up to 48% of methionine metabolism occurs in the liver [12]. C-11 methionine has been used as a tracer for oncologic PET studies.…”

Section: Evaluation Of Hepatic Functional Reservementioning

confidence: 99%

“…Otsuki et al [12] performed C-11 methionine PET in 11 patients with malignant tumors of the hepatic hilus, to evaluate residual liver functional reserve before major hepatectomy. Residual liver functional volume was quantitatively [the same] as the functional volume index.…”

Section: Evaluation Of Hepatic Functional Reservementioning

confidence: 99%

The use of positron emission tomography in hepatology

Shiomi

2005

Hepatology Research

View full text Add to dashboard Cite

Nuclear imaging methods for the prediction of postoperative morbidity and mortality in patients undergoing localized, liver-directed treatments: a systematic review

et al. 2020

View full text Add to dashboard Cite

Background: Several nuclear imaging methods may predict postoperative liver function and outcome, but none has achieved recommendations in clinical guidelines. The purpose of this systematic review was to summarize the existing knowledge on this topic. Methods: MEDLINE and Web of Science were searched for studies investigating nuclear medicine imaging methods for the prediction of postoperative liver function in patients undergoing localized, liver-directed treatments. The postoperative endpoints were clinical outcome (morbidity and mortality) as well as measures of postoperative liver function, e.g., liver function assessed by biochemical tests or nuclear imaging. Results: A total of 1352 references were identified, of which 82 fulfilled the eligibility criteria and were included in the review. Most studies (n = 63) were retrospective studies. The vast majority of studies assessed [ 99m Tc]Tcgalactosyl serum albumin (GSA) (n = 57) and [ 99m Tc]Tc-mebrofenin (n = 19). Liver resection was entirely or partly major (involved at least three segments) in 78 reports. There were notable variations in the research methodology, e.g., image acquisition, imaging variables, and endpoints. Thirty-seven studies reported on postoperative mortality, of which most reported descriptive data at the patient level. Of the four reports that performed multivariate analyses, two showed significant predictive results of isotope-based preoperative tests. Fifty-two papers presented data on postoperative liver failure. Multivariate predictive analyses were performed in eighteen trials, of which fifteen showed the significant value of nuclear medicine tests. Conclusion: There is sparse evidence supporting the significant value of nuclear medicine imaging methods in predicting postoperative mortality. In contrast, a notable number of trials showed a significant prediction of liver failure in multivariate analyses. The research methodology was heterogeneous and exploratory in most trials. Documentation of nuclear medicine tests in this setting awaits the results of properly designed, prospective trials with the standardization of both the nuclear medicine test and endpoints.

show abstract

Preoperative evaluation of residual liver function for extended hepatic resection with positron emission tomography and -[methyl-C] methionine

Cited by 5 publications

References 5 publications

Assessment of residual liver functional reserve after portal embolization with positron emission tomography usingl-[methyl-11C] methionine and computed tomography

Assessment of residual liver functional reserve after portal embolization with positron emission tomography usingl-[methyl-11C] methionine and computed tomography

The use of positron emission tomography in hepatology

Nuclear imaging methods for the prediction of postoperative morbidity and mortality in patients undergoing localized, liver-directed treatments: a systematic review

Contact Info

Product

Resources

About