Background
Published appropriate use criteria (AUC) for Mohs micrographic surgery (MMS) for melanoma are based on consensus opinion.
Objective
To evaluate whether published AUC identify melanomas for which MMS may benefit patients by detecting subclinical spread or confirming clear microscopic margins prior to flap or graft reconstruction.
Materials and methods
Retrospective cohort study of 591 melanomas in 556 patients evaluating the correlation between current AUC (anatomic location, recurrent status, and tumor stage) and subclinical spread or reconstruction with a flap or graft.
Results
Anatomic location on the head, neck, genitalia, hands, feet, or pretibial leg was significantly associated with a higher frequency of subclinical spread (OR 1.89, p=0.0280) and flap or graft reconstruction (OR 10.3, p=0.0001). Compared to primary lesions, recurrent melanomas had a higher frequency of subclinical spread (OR 1.78, p=0.0104) and reconstruction with a flap or graft (OR 1.67, p=0.0217). The frequencies of subclinical spread and flap or graft reconstruction did not differ between in situ and invasive melanomas.
Conclusion
Anatomic location and recurrent status are useful criteria to identify melanomas that may benefit from MMS. Tumor stage is not a useful criterion, as MMS has similar benefits for subsets of both invasive and in situ melanomas.