Preoperative Frailty Predicts Postoperative Long-Term Cognitive Decline Independent of Delirium

Racine, Annie M.; Jones, Richard N.; Gou, Yun; Fong, Tct; Ngo, Liem Viet; Travison, Thomas G.; Inouye, Sharon K.; Marcantonio, Edward R.

doi:10.1093/geroni/igy023.2112

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“…The studies have yielded mixed results, but a meta-analysis from 2016 found no association between the APOEε4 allele and the occurrence of delirium (562). Moreover, AD-associated brain atrophy measures like AD-signature cortical thickness and hippocampal volumes have been associated with delirium incidence, duration or severity in some studies (563)(564)(565)(566), but not all (567). Hippocampal microstructural abnormalities have also been associated with delirium incidence and severity (568).…”

Section: The Interrelationship Between Ad Pathologies and Deliriummentioning

confidence: 99%

CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults

Idland

Sala‐Llonch

Borza

et al. 2017

Neurobiology of Aging

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Cerebrospinal fluid (CSF) neurofilament light (NFL) is a marker of axonal degeneration. We tested whether CSF NFL levels predict hippocampal atrophy rate in cognitively healthy older adults independently of the established CSF Alzheimer's disease (AD) biomarkers, β-amyloid 1-42, and phosphorylated tau (P-tau). We included 144 participants in a 2-year longitudinal study with baseline CSF measures and 2 magnetic resonance images. Eighty-eight participants had full data available. A subgroup of 36 participants with very low AD risk was also studied. NFL predicted hippocampal atrophy rate independently of age, β-amyloid 1-42, and P-tau. Including NFL, P-tau, and age in the same model, higher NFL and lower P-tau predicted higher hippocampal atrophy (R = 0.20, NFL: β = -0.34; p = 0.003; P-tau: β = 0.27; p = 0.009). The results were upheld in the participants with very low AD risk. NFL predicted neurodegeneration in older adults with very low AD probability. We suggest that factors previously shown to be important for brain degeneration in mild cognitive impairment may also impact changes in normal aging, demonstrating that NFL is likely to indicate AD-independent, age-expected neurodegeneration.

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Section: The Interrelationship Between Ad Pathologies and Deliriummentioning

confidence: 99%

CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults

Idland

Sala‐Llonch

Borza

et al. 2017

Neurobiology of Aging

View full text Add to dashboard Cite

show abstract

Preoperative Frailty Predicts Postoperative Long-Term Cognitive Decline Independent of Delirium

Cited by 1 publication

References 0 publications

CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults

CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults

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