2016
DOI: 10.1007/s00268-016-3763-z
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Preoperative Glycosylated Hemoglobin Levels Predict Anastomotic Leak After Esophagectomy with Cervical Esophagogastric Anastomosis

Abstract: Preoperative HbA1c level was significantly associated with the development of AL after cervical esophagogastric anastomosis. We recommend preoperative HbA1c screening for all patients scheduled to undergo esophagectomy.

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Cited by 36 publications
(30 citation statements)
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“…An anastomotic route that is too long could cause excessive anastomotic tension, lack of blood supply to the tissue, and an elevated incidence of AL. Other potential risk factors, including smoking history and diabetic microangiopathy, in theory, may reduce microperfusion of tissues [19,27]. The probability of postoperative AL is higher in men than in women; however, this difference is not clinically significant, which is consistent with the results from Vaporciyan AA [11].…”
Section: Discussionsupporting
confidence: 71%
“…An anastomotic route that is too long could cause excessive anastomotic tension, lack of blood supply to the tissue, and an elevated incidence of AL. Other potential risk factors, including smoking history and diabetic microangiopathy, in theory, may reduce microperfusion of tissues [19,27]. The probability of postoperative AL is higher in men than in women; however, this difference is not clinically significant, which is consistent with the results from Vaporciyan AA [11].…”
Section: Discussionsupporting
confidence: 71%
“…Therefore, evaluation and management should be different according to the existence of an anastomotic leak (1,(5)(6)(7)(8). Prior studies have evaluated the early prediction of anastomotic leak after esophagectomy using laboratory findings (9)(10)(11)(12). However, there were few studies addressing the prediction of anastomotic leak after esophagectomy in patients who have received neoadjuvant therapy (NT).…”
Section: Introductionmentioning
confidence: 99%
“…Other studies have also evaluated laboratory values in the early prediction of anastomotic leak after esophagectomy (10,12,17). However, there has not been extensive investigation of the prediction of anastomotic leak after esophagectomy using routine laboratory findings in patients who have undergone NT.…”
mentioning
confidence: 99%
“…Among the laboratory factors examined in this study, a significantly decreased postoperative albumin level and renal dysfunction were identified as independent risk factors, possibly because patients that usually suffer from systemic inflammatory response syndrome exhibit an increased catabolic rate in their protein tissue, and display a decrease in the synthetic rate once anastomotic fistula occurs. 17 As a result of developing anastomotic fistula, the blood albumin level decreases and serum creatinine and urea nitrogen levels increase. If the two laboratory indexes of the patients are abnormal in the early stage, the occurrence of anastomotic fistula should be considered when imaging examination is unavailable.…”
Section: Discussionmentioning
confidence: 99%