Preoperative Immunostimulation with Propionibacterium avidum KP-40 in Patients with Gastric Carcinoma: A Prospective Randomized Study

Peters, Kirsten; Beuth, Josef; Ko, H.L.; Pulverer, G.; Kluger, Jeffrey; Grundmann, R

doi:10.1159/000216738

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…According to in vitro and in vivo model results obtained during the early 1990s, the Pulverer group in Germany decided to move from the bench to the bedside with prospective randomized studies including patients with gastrointestinal tumors (212). No effect was observed regarding postoperative complications or tumor recurrence rates between the control and treatment groups (212), but after a preoperative intravenous (i.v.) infusion of 10 mg of the whole C. avidum KP-40 preparation, they demonstrated enhanced neopterin secretion in urine, with persistence of this biomarker.…”

Section: Antitumor Activitymentioning

confidence: 99%

“…infusion of 10 mg of the whole C. avidum KP-40 preparation, they demonstrated enhanced neopterin secretion in urine, with persistence of this biomarker. Indeed, neopterin is considered to be an early signal of the cellular immune response (126). They also highlighted that only a lymphocyte subset population (the natural killer cell population) was statistically increased following infusion of the same preparation (same dose) (110,111).…”

Section: Antitumor Activitymentioning

confidence: 99%

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Clinical and Biological Features of Cutibacterium (Formerly Propionibacterium)avidum, an Underrecognized Microorganism

Corvec

2018

Clin Microbiol Rev

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The recent description of the genus has altered the taxonomy of species. These organisms still belong to the genera of the skin coryneform group, and the most-studied species remains . is also a known skin commensal. This underrecognized microorganism can, however, act as a pathogen after bacterial seeding and can be considered opportunistic, causing either superficial or deep/invasive infections. It can cause numerous infections, including but not limited to breast infections, skin abscesses, infective endocarditis, and device-related infections. The ecological niche of is clearly different from that of other members of the genus: it is found in the axillary region or at wet sites rather than in dry, exposed areas, and the number of microorganisms increases during puberty. Historically, it has been used for its ability to modulate the immune response and for its antitumor properties. Conventional microbial culture methods and identification processes allow for its accurate identification and characterization. Thanks to the modern omics tools used for phylogenomic approaches, understanding pathogenesis (including host-bacterium interactions and virulence factor characterization) is becoming easier, allowing for more thorough molecular characterization. These analyses have revealed that causes diverse diseases mediated by multiple virulence factors. The recent genome approach has revealed specific genomic regions within this species that are involved in adherence and biofilm formation as well as fitness, survival, and defense functions. Numerous regions show the presence of phages and horizontal gene transfer. remains highly sensitive to a broad spectrum of antibiotics, such as β-lactams, fluoroquinolones, macrolides, and rifampin, although erythromycin and clindamycin resistance has been described. A long-term treatment regimen with a combination of antibiotics is required to successfully eliminate the remaining adherent bacteria, particularly in the case of deep infections after debridement surgery.

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Section: Antitumor Activitymentioning

confidence: 99%

Section: Antitumor Activitymentioning

confidence: 99%