Preoperative Intravenous Iron Treatment in Colorectal Cancer: Experience From Clinical Practice

Ploug, Magnus; Krøijer, Rasmus; Qvist, Niels; Knudsen, Torben

doi:10.1016/j.jss.2022.03.004

Cited by 14 publications

(51 citation statements)

References 21 publications

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“…Three RCTs were published in 2022, [22][23][24] while 1 RCT was published in 2021. 25 One nonrandomized study was published in 2022, 26 while 5 non-randomized studies were published in 2021. [27][28][29][30][31] Five of the non-randomized studies were retrospective cohort studies that used historical patient data in their analysis.…”

Section: Methodsmentioning

confidence: 99%

“…[27][28][29][30][31] Five of the non-randomized studies were retrospective cohort studies that used historical patient data in their analysis. [26][27][28][29][30] One non-randomized study was a multicenter prospective cohort study that used prospectively collected patient data. 31 When reported, patient follow-up time varied across studies depending on the outcome being reported, but ranged from 21 days to 3 months.…”

Section: Methodsmentioning

confidence: 99%

“…Six SRs [16][17][18][19][20][21] including 3 with meta-analysis (MA), 16,17,19 4 RCTs, [22][23][24][25] 6 non-randomized studies, [26][27][28][29][30][31] and 1 evidence-based guideline 32 was included in this report.…”

Section: Summary Of Study Characteristicsmentioning

confidence: 99%

“…19 The included RCTs were conducted in Hong Kong, 22 Norway, 23 Egypt, 24 and Singapore. 25 The included non-randomized studies were conducted in Denmark, 26 Singapore, 27 the UK, 28,30 Canada, 29 and Germany. 31 The included evidence-based guideline was conducted in Canada.…”

Section: Country Of Originmentioning

confidence: 99%

“…One non-randomized study included adult patients undergoing colorectal cancer surgery with iron deficiency anemia. 26 One non-randomized study included adult elective cardiac and aortic surgical patients with iron deficiency and anemia. 30 The target population for the included evidence-based guideline was patients with comorbid condition, specifically anemia, hyperglycemia, and smoking, undergoing major surgery.…”

Section: Patient Populationmentioning

confidence: 99%

See 4 more Smart Citations

Intravenous Iron Preparations for Patients Undergoing Elective Surgery: A 2022 Update

Hill¹,

Severn²

2022

cjht

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For adults who are iron deficient before elective surgery, patients who received IV iron supplementation may have greater increases in hemoglobin and ferritin concentrations, similar or lower lengths of stay in hospital, and similar quality of life measures, functional outcomes, and rates of adverse events, compared to patients who did not receive IV supplementation. The findings were mixed for the rate of blood transfusions. For adults who are iron deficient before elective surgery, patients who received IV iron supplementation may experience similar changes in hemoglobin levels, quality of life scores, or number of adverse events when compared to patients who received oral iron supplementation. The findings were mixed regarding the risk of blood transfusions. No studies were found on the cost-effectiveness of IV iron preparation therapy for patients who are iron deficient undergoing elective surgery that met the criteria for this review. One guideline recommends the use of IV iron supplementation for patients with iron deficient anemia when surgery is less than 8 weeks away, patients are unable to tolerate or absorb oral iron supplementation, or for patient with suboptimal hemoglobin levels.

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