Preoperative Mapping of the Supplementary Motor Area in Patients with Brain Tumor Using Resting-State fMRI with Seed-Based Analysis

Wongsripuemtet, Jitsupa; Tyan, Andrew E.; Carass, Aaron; Agarwal, Shruti; Gujar, Sachin K.; Pillai, Jay J.; Sair, Haris I.

doi:10.3174/ajnr.a5709

Cited by 12 publications

(17 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Attempts at spatio-functional SMA delineation have been made using techniques such as functional magnetic resonance imaging (fMRI), magnetoencephalography (MEG), and positron emission tomography (PET) 22–25 . In one case study, MEG activity corresponding to voluntary movement preparation was recorded in a stroke patient possessing only one active SMA 23 .…”

Section: Introductionmentioning

confidence: 99%

“…The study, however, mentions that MEG may at times be unable to record SMA activity due to both hemispheres canceling out each other’s recordable signal 23 . Whereas in two studies on 18 and 66 participants, fMRI has been used to some success in the localization of the SMA, there are reports of variable visibility in identification by resting-state fMRI 22,25 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Navigated transcranial magnetic stimulation of the supplementary motor cortex disrupts fine motor skills in healthy adults

Schramm

Albers

Ille

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Navigated transcranial magnetic stimulation (nTMS) over the supplementary motor area (SMA) may impact fine motor skills. This study evaluates different nTMS parameters in their capacity to affect fine motor performance on the way to develop an SMA mapping protocol. Twenty healthy volunteers performed a variety of fine motor tests during baseline and nTMS to the SMA using 5 Hz, 10 Hz, and theta-burst stimulation (TBS). Effects on performance were measured by test completion times (TCTs), standard deviation of inter-tap interval (SDIT), and visible coordination problems (VCPs). The predominant stimulation effect was slowing of TCTs, i.e. a slowdown of test performances during stimulation. Furthermore, participants exhibited VCPs like accidental use of contralateral limbs or inability to coordinate movements. More instances of significant differences between baseline and stimulation occurred during stimulation of the right hemisphere compared to left-hemispheric stimulation. In conclusion, nTMS to the SMA could enable new approaches in neuroscience and enable structured mapping approaches. Specifically, this study supports interhemispheric differences in motor control as right-hemispheric stimulation resulted in clearer impairments. The application of our nTMS-based setup to assess the function of the SMA should be applied in patients with changed anatomo-functional representations as the next step, e.g. among patients with eloquent brain tumors.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Navigated transcranial magnetic stimulation of the supplementary motor cortex disrupts fine motor skills in healthy adults

Schramm

Albers

Ille

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Further in practice, the network identified by ICA, if present, must be individually selected out by the investigator [6]. Resting-state SBC analysis is a hypothesis-driven method and more intuitive in targeting a specific language functional area of interest; however, a priori target must be determined, and this varies between studies [16]. In 19 patients, Cochereau et al showed a significant correlation between language networks identified with SBC rs-fMRI and eloquent language cortex confirmed with direct cortical stimulation [17].…”

Section: Discussionmentioning

confidence: 99%

The role of resting-state functional MRI for clinical preoperative language mapping

et al. 2020

View full text Add to dashboard Cite

Background: Task-based functional MRI (tb-fMRI) is a well-established technique used to identify eloquent cortex, but has limitations, particularly in cognitively impaired patients who cannot perform language paradigms. Restingstate functional MRI (rs-fMRI) is a potential alternative modality for presurgical mapping of language networks that does not require task performance. The purpose of our study is to determine the utility of rs-fMRI for clinical preoperative language mapping when tb-fMRI is limited. Methods: We retrospectively reviewed 134 brain tumor patients who underwent preoperative fMRI language mapping. rs-fMRI was post-processed with seed-based correlation (SBC) analysis, when language tb-fMRI was limited. Two neuroradiologists reviewed both the tb-fMRI and rs-fMRI results. Six neurosurgeons retrospectively rated the usefulness of rs-fMRI for language mapping in their patients. Results: Of the 134 patients, 49 cases had limited tb-fMRI and rs-fMRI was post-processed. Two neuroradiologists found rs-fMRI beneficial for functional language mapping in 41(84%) and 43 (88%) cases respectively; Cohen's kappa is 0.83, with a 95% confidence interval (0.61, 1.00). The neurosurgeons found rs-fMRI "definitely" useful in 26 cases (60%) and "somewhat" useful in 13 cases (30%) in locating potential eloquent language centers of clinical interest. Six unsuccessful rs-fMRI cases were due to: head motion (2 cases), nonspecific functionality connectivity outside the posterior language network (1 case), and an unknown system instability (3 cases). Conclusions: This study is a proof of concept that shows SBC rs-fMRI may be a viable alternative for clinical language mapping when tb-fMRI is limited.

show abstract

“…While rs-fMRI is currently being used for preoperative planning in a few centers (20), other clinical applications are not as common. High within-subject reproducibility of RSNs suggests that they might serve as biomarkers for monitoring disease progression in individual patients (21).…”

Section: Discussionmentioning

confidence: 99%

“…Global signal regression (20) is another method sometimes used for physiologic noise reduction (37). GSR uses a denoising covariate that contains information from both physiological noise and neural signal.…”

Section: Discussionmentioning

confidence: 99%

Why is Clinical fMRI in a Resting State?

O’Connor

Zeffiro

2019

Front. Neurol.

View full text Add to dashboard Cite

While resting state fMRI (rs-fMRI) has gained widespread application in neuroimaging clinical research, its penetration into clinical medicine has been more limited. We surveyed a neuroradiology professional group to ascertain their experience with rs-fMRI, identify perceived barriers to using rs-fMRI clinically and elicit suggestions about ways to facilitate its use in clinical practice. The electronic survey also collected information about demographics and work environment using Likert scales. We found that 90% of the respondents had adequate equipment to conduct rs-fMRI and 82% found rs-fMRI data easy to collect. Fifty-nine percent have used rs-fMRI in their past research and 72% reported plans to use rs-fMRI for research in the next year. Nevertheless, only 40% plan to use rs-fMRI in clinical practice in the next year and 82% agreed that their clinical fMRI use is largely confined to pre-surgical planning applications. To explore the reasons for the persistent low utilization of rs-fMRI in clinical applications, we identified barriers to clinical rs-fMRI use related to the availability of robust denoising procedures, single-subject analysis techniques, demonstration of functional connectivity map reliability, regulatory clearance, reimbursement, and neuroradiologist training opportunities. In conclusion, while rs-fMRI use in clinical neuroradiology practice is limited, enthusiasm appears to be quite high and there are several possible avenues in which further research and development may facilitate its penetration into clinical practice.

show abstract

Preoperative Mapping of the Supplementary Motor Area in Patients with Brain Tumor Using Resting-State fMRI with Seed-Based Analysis

Abstract: In addition to task-based fMRI, seed-based analysis of resting-state fMRI represents an equally effective method for supplementary motor area localization in patients with brain tumors, with the best results obtained with bilateral hand motor region seeding.

Cited by 12 publications

References 31 publications

Navigated transcranial magnetic stimulation of the supplementary motor cortex disrupts fine motor skills in healthy adults

Navigated transcranial magnetic stimulation of the supplementary motor cortex disrupts fine motor skills in healthy adults

The role of resting-state functional MRI for clinical preoperative language mapping

Why is Clinical fMRI in a Resting State?

Contact Info

Product

Resources

About