Preoperative Neutrophil-Lymphocyte Ratio as an Independent Prognostic Marker for Patients With Upper Urinary Tract Urothelial Carcinoma

The neutrophil-to-lymphocyte ratio is an effective prognostic marker in localized upper urinary tract urothelial carcinoma treated with nephroureterectomy

“…In urothelial carcinoma, our previous reports showed the cut-off points as 2.38 for the patients who received radical cystectomy and the other reports in bladder cancer showed similar cut-off point (2.38 -3.0) [11]. For UUT-UC, the cut-off points were 2.5 to 2.7 [19,20]. Our results also supported that data.…”

“…Some of these studies revealed correlations between NLR and prognosis of patients with UUT-UC who underwent nephroureterectomy [17][18][19][20]. In urothelial carcinoma, our previous reports showed the cut-off points as 2.38 for the patients who received radical cystectomy and the other reports in bladder cancer showed similar cut-off point (2.38 -3.0) [11].…”

The Prognostic Significance of the Early Postoperative Neutrophil-to-Lymphocyte Ratio in Patients with Urothelial Carcinoma of the Bladder Undergoing Radical Cystectomy

“…To determine the optimal cutoff point of NLR, receiver operating characteristics (ROC) curve analysis was used, and cutoff values were chosen to maximize specificity, sensitivity, or both. [17][18][19] We compared the clinicopathologic parameters between the two groups by using the chi-square test for categorical variables and the Mann-Whitney U test for continuous variables. The Wilcoxon signed-rank test was used to compare the variables at pre-and postoperative time points in the same population.…”

The Safety and Efficacy of Single-Agent Pemetrexed in Platinum-Resistant Advanced Urothelial Carcinoma: A Large Single-Institution Experience

“…Previous work in multiple malignancies has shown NLR to have prognostic significance independent of other well-known risk factors [15,16]. In localized bladder and upper tract urothelial cancer, it was shown to have independent prognostic significance at cut-off values of 2.5 and 3.0 in different studies [17][18][19][20].…”