Preoperative nonmedical predictors of functional impairment after brain tumor surgery

Schiavolin, Silvia; Mariniello, Arianna; Broggi, Morgan; DiMeco, Francesco; Ferroli, Paolo; Leonardi, Matilde

doi:10.1007/s00520-021-06732-6

Cited by 6 publications

(4 citation statements)

References 37 publications

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“…These non-clinical predictors extend beyond medical and surgical considerations, integrating individual characteristics such as social, psychological, and cognitive elements. These factors are typically assessed by clinicians, while they can also be directly reported by patients through PROMs [14].…”

Section: Non-clinical Risk Factorsmentioning

confidence: 99%

“…Psychological attributes, including the presence of depressive and anxiety symptoms, altered mental states, independence in daily activities, and personality typologies, have also emerged as notable non-medical predictors influencing HRQoL. Furthermore, cognitive functions encompassing language deficits, attention spans, executive functions, psychomotor velocity, global cognitive functioning, and working memory have been studied as salient predictors of postoperative outcomes [14].…”

Section: Non-clinical Risk Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Quality of Life in Patients with Meningioma

Merati,

Montazeri,

Mohebi

et al. 2024

Meningioma - The Essentials From Bench to Bedside

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Meningiomas are common benign brain tumors that may significantly impact patients’ Health-Related Quality of Life (HRQOL) and functional disability. The assessment of HRQOL in meningioma patients is heterogeneous, necessitating standardized approaches. Patient-Reported Outcome Measures (PROMs) are increasingly used to capture patients’ perspectives, with various questionnaires developed for this purpose. Medical and non-medical risk factors for long-term HRQOL impairment encompass tumor characteristics, treatment factors, and sociodemographic features. Symptomatic meningioma patients experience lower HRQOL scores, with symptoms influenced by tumor features such as location, edema, and size. Prominent subsequent manifestations, including epilepsy, neurocognitive dysfunction, and psychiatric symptoms, significantly influence HRQOL. Surgical resection is the primary therapeutic option, and adjuvant radiotherapy may be considered for recurrent or high-risk cases. Although patients generally experience improved HRQOL post-surgery, some may face long-term declines, necessitating comprehensive long-term well-being evaluation. Patients often undergo positive changes in mental outlook (posttraumatic growth), triggering a “response shift” that may alter patients’ values and internal standards, ultimately improving their perception of HRQOL. Long-term outcomes highlight meningioma’s chronic impact on patients’ lives and socioeconomic burden. Overall, understanding and addressing these factors optimizes patients’ well-being and functional outcomes. A holistic approach considering medical and psychosocial aspects is crucial for enhancing HRQOL in meningioma patients.

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Section: Non-clinical Risk Factorsmentioning

confidence: 99%

Section: Non-clinical Risk Factorsmentioning

confidence: 99%

Quality of Life in Patients with Meningioma

Merati,

Montazeri,

Mohebi

et al. 2024

Meningioma - The Essentials From Bench to Bedside

View full text Add to dashboard Cite

show abstract

“…However, the same study reported discrete impairments in about 50% of patients in memory and executive functions. Importantly, previous evidence indicated that poorer cognitive functioning is associated with lower quality of life (Boele et al, 2014) difficulties in daily functioning (Gonen et al, 2017; Schiavolin et al, 2021, 2022), and worse outcomes after surgery (Schiavolin et al, 2021). In this sense, Moritz‐Gasser et al (2012) showed that the speed of lexical access significantly correlates with the return to professional activities after awake surgery in people with low‐grade gliomas.…”

Section: Introductionmentioning

confidence: 98%

Understanding language and cognition after brain surgery – Tumour grade, fine‐grained assessment tools and, most of all, individualized approach

Gasa‐Roqué,

Rofes,

Simó

et al. 2023

Journal of Neuropsychology

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Cognitive performance influences the quality of life and survival of people with glioma. Thus, a detailed neuropsychological and language evaluation is essential. In this work, we tested if an analysis of errors in naming can indicate semantic and/or phonological impairments in 87 awake brain surgery patients. Secondly, we explored how language and cognition change after brain tumour resection. Finally, we checked if low‐tumour grade had a protective effect on cognition. Our results indicated that naming errors can be useful to monitor semantic and phonological processing, as their number correlated with scores on tasks developed by our team for testing these domains. Secondly, we showed that – although an analysis at a whole group level indicates a decline in language functions – significantly more individual patients improve or remain stable when compared to the ones who declined. Finally, we observed that having LGG, when compared with HGG, favours patients' outcome after surgery, most probably due to brain plasticity mechanisms. We provide new evidence of the importance of applying a broader neuropsychological assessment and an analysis of naming errors in patients with glioma. Our approach may potentially ensure better detection of cognitive deficits and contribute to better postoperative outcomes. Our study also shows that an individualized approach in post‐surgical follow‐ups can reveal reassuring results showing that significantly more patients remain stable or improve and can be a promising avenue for similar reports. Finally, the study captures that plasticity mechanisms may act as protective in LGG versus HGG after surgery.

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“…In addition, cognitive function may also reflect the subclinical lesion before imaging examination, which may help clinicians to detect insidious tumor progression earlier (Brown et al 2006 ). At present, numerous scales have been used to assess cognitive function in patients with intracranial tumors, and as verified scales with high feasibility and validity, the Mini-Mental State Examination (MMSE, RRID:SCR_003681) (Folstein et al 1975 ) and the Montreal Cognitive Assessment (MoCA) (Nasreddine et al 2005 ) are the two main scales in cognitive function screening (Olson et al 2008 ; Renovanz et al 2018 ; Jia et al 2021 ; Schiavolin et al 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Molecular Determinants of Neurocognitive Deficits in Glioma: Based on 2021 WHO Classification

Zhang,

Yang,

Xia

et al. 2024

J Mol Neurosci

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Cognitive impairment is a common feature among patients with diffuse glioma. The objective of the study is to investigate the relationship between preoperative cognitive function and clinical as well as molecular factors, firstly based on the new 2021 World Health Organization’s updated classification of central nervous system tumors. A total of 110 diffuse glioma patients enrolled underwent preoperative cognitive assessments using the Mini-Mental State Examination and Montreal Cognitive Assessment. Clinical information was collected from medical records, and gene sequencing was performed to analyze the 18 most influenced genes. The differences in cognitive function between patients with and without glioblastoma were compared under both the 2016 and 2021 WHO classification of tumors of the central nervous system to assess their effect of differentiation on cognition. The study found that age, tumor location, and glioblastoma had significant differences in cognitive function. Several genetic alterations were significantly correlated with cognition. Especially, IDH, CIC, and ATRX are positively correlated with several cognitive domains, while most other genes are negatively correlated. For most focused genes, patients with a low number of genetic alterations tended to have better cognitive function. Our study suggested that, in addition to clinical characteristics such as age, histological type, and tumor location, molecular characteristics play a crucial role in cognitive function. Further research into the mechanisms by which tumors affect brain function is expected to enhance the quality of life for glioma patients. This study highlights the importance of considering both clinical and molecular factors in the management of glioma patients to improve cognitive outcomes.

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Preoperative nonmedical predictors of functional impairment after brain tumor surgery

Cited by 6 publications

References 37 publications

Quality of Life in Patients with Meningioma

Quality of Life in Patients with Meningioma

Understanding language and cognition after brain surgery – Tumour grade, fine‐grained assessment tools and, most of all, individualized approach

Molecular Determinants of Neurocognitive Deficits in Glioma: Based on 2021 WHO Classification

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