Preoperative portal vein embolization improves prognosis after right hepatectomy for hepatocellular carcinoma in patients with impaired hepatic function

Tanaka, Hiromu; Hirohashi, Kazuhiro; Kubo, Shoji; Shuto, Taichi; Higaki, Ikko; Kinoshita, Hiroaki

doi:10.1046/j.1365-2168.2000.01438.x

Cited by 126 publications

(83 citation statements)

References 11 publications

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“…Our present results showed that changes in hepatic volumes did not differ significantly between normal and impaired liver, although changes of liver volume tended to be lower in liver cirrhosis. Therefore, PVE can be applied for even patients with diseased liver as previously reported [26,28].…”

Section: Discussionmentioning

confidence: 99%

Relationship of Hepatic Functional Parameters with Changes of Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization: A Follow-Up Report

Nanashima¹,

Tobinaga²,

Abo³

et al. 2010

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Relationship of Hepatic Functional Parameters with Changes of Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization: A Follow-Up Report

Nanashima¹,

Tobinaga²,

Abo³

et al. 2010

Journal of Surgical Research

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“…27,209 Chemoembolization of the tumor prior to resection offers no benefit. 210 The same is true for the general use of portal vein embolization of the hepatic lobe hosting the tumor 211,212 to induce compensatory liver growth and functional capacity in the non-affected lobe prior to a major resection. It has also been suggested that malignant hepatocytes may also respond to the proliferative stimulus and this could result in uncontrolled tumor progression.…”

Section: Surgical Resectionmentioning

confidence: 99%

Management of Hepatocellular Carcinoma *

2005

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“…However, Wu et al found effective preoperative TACE might be one of the best methods for resectable HCCs including small HCCs for improving disease-free survival after hepatectomy [74] . Preoperative portal vein embolization could improve prognosis after right hepatectomy for HCC in patients with impaired hepatic function, but cannot prevent tumor recurrence after HCC resection [75] . Main portal branch transection combined with major liver resection and neoadjuvant and adjuvant locoregional immunochemotherapy could increase the resectability rate and the overall survival and DFS [76] .…”

Section: Preoperative Adjuvant Therapy (Neoadjuvant Therapy)mentioning

confidence: 99%

The prognostic significance of clinical and pathological features in hepatocellular carcinoma

Qin¹,

Tang²

2002

WJG

161

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The prognosis of patients with HCC still remains dismal. The life expectancy of HCC patients is hard to predict because of the high possibility of postoperative recurrence. Many factors, s u c h a s p a t i e n t ' s g e n e r a l c o n d i t i o n s , macroscopic tumor morphology, as well as tumor hitopathology features, have been proven of prognostic significance. Female HCC patient often has a better prognosis than male patient, which might be due to the receptor of sex hormones. Younger patients often have tumors with higher invasiveness and metastatic potentials, and their survival and prognosis are w o r s e t h a n t h e o l d e r o n e s . C o -e x i s t i n g hepatitis status and hepatic functional reserve h a v e b e e n c o n f i r m e d a s r i s k f a c t o r s f o r recurrence. Serum alpha-fetoprotein (AFP) is useful not only for diagnosis, but also as a prognostic indicator for HCC patients. AFP mRNA has been proposed as a predictive marker of HCC cells disseminated into the circulation and for metastatic recurrence. Many pathologic features, such as tumor size, number, capsule state, cell differentiation, venous invasion, intrahepatic spreading, and a d v a n c e d p T N M s t a g e , a r e t h e b e s testablished risk factors for recurrence and important aspects affecting the prognosis of patients with HCC. Marked inflammatory cell infiltration in the tumor could predict a better prognosis. Clinical stage is still the most important factor influencing on the prognosis. E x t r a t u m o r s p r e a d i n g a n d l y m p h n o d a l metastasis are independent predictors for poor outcome. Some new predictive systems h a v e r e c e n t l y b e e n p r o p o s e d . D i f f e r e n t strategies of treatment might have significant different effects on the patients' prognosis. To date, surgical resection is still the only p o t e n t i a l l y c u r a t i v e t r e a t m e n t f o r H C C , including localized postoperative recurrences. Extent of resection, blood transfusion, occlusion of porta hepatis, and blood loss affect the survival and prognosis of HCC patients. Regional therapies provide alternative ways to improve the prognosis of HCC patients who have no opportunity to receive surgical treatment or postoperative recurrence. The combination of these treatment modalities is hopeful to further improve the prognosis. The efficacies of neoadjuvant (preoperative) or adjuvant (postoperative) chemotherapy or chemoembolization in preventing recurrence and on the HCC prognosis still remain great controversy, and deserves further evaluation. Biotherapy, including IFN-alpha therapy, will play more important role in preventing recurrence and metastasis of HCC after operation.Qin LX,Tang ZY.The prognostic significance of clinical and pathological features in hepatocellular carcinoma.

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Preoperative portal vein embolization improves prognosis after right hepatectomy for hepatocellular carcinoma in patients with impaired hepatic function

Abstract: Preoperative PTPE improves the prognosis after right hepatectomy for HCC in patients with impaired hepatic function, although it does not prevent tumour recurrence.

Cited by 126 publications

References 11 publications

Relationship of Hepatic Functional Parameters with Changes of Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization: A Follow-Up Report

Relationship of Hepatic Functional Parameters with Changes of Functional Liver Volume Using Technetium-99m Galactosyl Serum Albumin Scintigraphy in Patients Undergoing Preoperative Portal Vein Embolization: A Follow-Up Report

Management of Hepatocellular Carcinoma *

The prognostic significance of clinical and pathological features in hepatocellular carcinoma

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