Preoperative prediction of muscular invasiveness of bladder cancer with radiomic features on conventional MRI and its high-order derivative maps

Abstract

3D radiomic signatures derived from T2WI and its high-order derivative maps could reflect muscular invasiveness of bladder cancer, and the proposed strategy can be used to facilitate the preoperative prediction of muscular invasiveness in patients with bladder cancer.

A predictive nomogram for individualized recurrence stratification of bladder cancer using multiparametric MRI and clinical risk factors

“…Based on these findings above, we hypothesized that: 1) the radiomics features extracted from preoperative mpMRI to characterize the subtle variations of tissue distribution within the lesion might be potential in predicting BCa recurrence; 2) the combination of the radiomics strategy with important clinical factors, mainly including age, gender, histological grade, and MIS of the archived tumor with the maximal size in bladder lumen, tumor size, NoT, operation choice, together with the imaging signs like stalk and SLE, might add the incremental value for TFTY BCa prediction.…”

Quantitative Identification of Nonmuscle‐Invasive and Muscle‐Invasive Bladder Carcinomas: A Multiparametric MRI Radiomics Analysis

“…Clinical management of BC predominantly relies on muscle invasion and stage of the carcinoma . For instance, patients with nonmuscle‐invasive BC (NMIBC, stage ≤T1) are mostly treated with transurethral resection (TUR) and adjuvant intravesical chemotherapy or photodynamic therapy, whereas patients with muscle‐invasive BC (MIBC, stage ≥T2) are treated with radical cystectomy (RC), radiation therapy, chemotherapy, and usually have a poor prognosis . Preoperatively, accurate discrimination between NMIBC and MIBC is therefore very important for treatment decision, prognosis, and follow‐up management of patients with BC.…”

“…The standard reference for preoperative discrimination between NMIBC and MIBC is cystoscopic examination with pathological evaluation of the resected tissues . Due to variations in performing resection, 20–80% of BCs were incorrectly staged . Multiple examinations could significantly reduce the diagnostic error, but is undesired due to the invasive, uncomfortable, time‐consuming, and costly procedures .…”

“…Due to variations in performing resection, 20–80% of BCs were incorrectly staged . Multiple examinations could significantly reduce the diagnostic error, but is undesired due to the invasive, uncomfortable, time‐consuming, and costly procedures . Developing a noninvasive approach for NMIBC and MIBC differentiation would be very beneficial for BC patients.…”

“…Magnetic resonance imaging (MRI) techniques have currently shown potential in determining tumor locations and characteristics in a noninvasive manner . Quantitative characterization of these images to build the associated bridge between image signatures and cancer properties, ie, radiomics, has attracted increasing attention .…”