Preoperative pyuria predicts advanced pathologic tumor stage and worse survival in patients with urothelial carcinoma of the upper urinary tract treated by radical nephroureterectomy

Effect of Preoperative Bacteriuria and Pyuria on Intravesical Recurrence in Patients with Upper Tract Urothelial Carcinoma Undergoing Radical Nephroureterectomy

“…Therefore, a bacteria-associated immune response may suppress the initiation and development of bladder cancer, a response which might potentially be similar to an immune response caused by the intravesical instillation of bacillus Calmette-Guerin. A single retrospective study showed that preoperative pyuria was a significant predictor for higher pT stage and worse overall survival (OS) in patients with UTUC treated with RNU (21). In the present study, patients with preoperative pyuria had worse OS than those without (5-year OS: 85% vs. 76%, p=0.044, data not shown), corresponding with the finding of the previous study.…”

Preoperative sterile pyuria as a prognosticbiomarker for intravesical recurrence in upperurinary tract urothelial carcinoma

“…In UTUC, preoperative pyuria has also been reported as a prognostic biomarker. Liang et al [13] first reported the association between preoperative pyuria and UTUC prognosis. Their retrospective analysis indicated that preoperative pyuria was significantly associated with advanced pathologic T stage.…”

“…Pyuria, easily identified using low-cost non-invasive urine tests, reflects the inflammatory state of the urinary tract. Numerous studies have reported that pyuria is a significant prognostic factor in urothelial carcinomas [11][12][13][14][15]. However, to date, only a few studies have evaluated whether sterile pyuria can be a predictive factor for IVR [12,13].…”

“…Numerous studies have reported that pyuria is a significant prognostic factor in urothelial carcinomas [11][12][13][14][15]. However, to date, only a few studies have evaluated whether sterile pyuria can be a predictive factor for IVR [12,13]. Thus, the purpose of this study was to evaluate if preoperative sterile pyuria can be a prognostic factor for IVR and overall survival (OS) in patients with UTUC undergoing surgery.…”

Prognostic significance of preoperative pyuria & neutrophil to lymphocyte ratio in patients with non-muscle-invasive bladder cancer: A prospective cohort study

“…Pyuria is a well-documented prognostic factor in urinary tract carcinomas, according to several research. [10][11][12][13][14] The relationship between preoperative pyuria and recurrence in patients with NMIBC is unclear, even though these studies found that pyuria was a strong predictor of poor prognosis in patients with NMIBC. Our study's objective was to compare the prognostic effect of pyuria and pre-treatment NLR on the likelihood of progression and recurrence in individuals with primary NMIBC.…”