Preoperative Radiochemotherapy and Radical Surgery of Advanced Head and Neck Cancers — Results of a Prospective, Multicenter DÖSAK Study

Mohr, C; Bohndorf, W; Gremmel, H; Härle, F; Hausamen, Jarg-Erich; Hirche, H.; Molls, M.; Renner, K; Reuther, J.; Sack, H.; D, Schettler; Scheunemann, H; Thelen, M.

doi:10.1007/978-3-642-84971-8_17

Cited by 13 publications

(5 citation statements)

References 4 publications

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“…assigned 268 patients to surgery alone or nCRT with 36 Gy and concomitant cisplatin (12.5 mg, days 1-5), followed by radical surgery 10-14 days after CRT completion. In this study, nCRT resulted in pCR of the primary tumors in 37% of the patients, and less locoregional relapses occurred after 3 years (31% vs. 16%) ( 38 ). Yi et al.…”

Section: Discussionmentioning

confidence: 57%

Neoadjuvant Chemoradiotherapy for Oral Cavity Cancer: Predictive Factors for Response and Interim Analysis of the Prospective INVERT-Trial

et al. 2022

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BackgroundTo study neoadjuvant chemoradiotherapy (nCRT) and potential predictive factors for response in locally advanced oral cavity cancer (LA-OCC).MethodsThe INVERT trial is an ongoing single-center, prospective phase 2, proof-of-principle trial. Operable patients with stage III-IVA squamous cell carcinomas of the oral cavity were eligible and received nCRT consisting of 60 Gy with concomitant cisplatin and 5-fluorouracil. Surgery was scheduled 6-8 weeks after completion of nCRT. Explorative, multiplex immunohistochemistry (IHC) was performed on pretreatment tumor specimen, and diffusion-weighted magnetic resonance imaging (DW-MRI) was conducted prior to, during nCRT (day 15), and before surgery to identify potential predictive biomarkers and imaging features. Primary endpoint was the pathological complete response (pCR) rate.ResultsSeventeen patients with stage IVA OCC were included in this interim analysis. All patients completed nCRT. One patient died from pneumonia 10 weeks after nCRT before surgery. Complete tumor resection (R0) was achieved in 16/17 patients, of whom 7 (41%, 95% CI: 18-67%) showed pCR. According to the Clavien-Dindo classification, grade 3a and 3b complications were found in 4 (25%) and 5 (31%) patients, respectively; grade 4-5 complications did not occur. Increased changes in the apparent diffusion coefficient signal intensities between MRI at day 15 of nCRT and before surgery were associated with better response (p=0.022). Higher abundances of programmed cell death protein 1 (PD1) positive cytotoxic T-cells (p=0.012), PD1+ macrophages (p=0.046), and cancer-associated fibroblasts (CAFs, p=0.036) were associated with incomplete response to nCRT.ConclusionnCRT for LA-OCC followed by radical surgery is feasible and shows high response rates. Larger patient cohorts from randomized trials are needed to further investigate nCRT and predictive biomarkers such as changes in DW-MRI signal intensities, tumor infiltrating immune cells, and CAFs.

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Section: Discussionmentioning

confidence: 57%

Neoadjuvant Chemoradiotherapy for Oral Cavity Cancer: Predictive Factors for Response and Interim Analysis of the Prospective INVERT-Trial

et al. 2022

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“…These patients were treated according to the Essen protocol ,24 receiving preoperative radiation therapy (36 Gy) and subsequent radical resection with a safety margin of at least 10 mm in patients with T2–T4N0–N3M0 disease. All 44 patients completed primary treatment and were classified histopathologically as having undergone R0 resection.…”

Section: Methodsmentioning

confidence: 99%

Likelihood inference in complex settings

Reid

2012

Can J Statistics

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Inference based on the likelihood function owes much to theory developed some decades ago. What is the current role of likelihood in developing strategies for the analysis of very large data sets, often with very high dimension, and complex dependencies? This paper considers some aspects of this question with emphasis on problems in stochastic modelling, estimating equations, and survey methodology.

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“…After histopathological classification of the tumour, the combined or multimodal therapy 6,8,9 was performed as follows: the patients underwent a radiochemotherapy with 15 mg mitomycin C/m 2 (day 1) and 75 mg 5-fluorouracil/m 2 (days 1-5) combined with a fractional irradiation of the tumour of 2 Gy per day (days 1-25). Prior to that, in general anaesthesia, the margins of the tumour were marked with black ink.…”

Section: Methodsmentioning

confidence: 99%

Two stage reconstruction with revascularized grafts after resection of retromolar and oropharyngeal carcinoma

Kermer

Ziya-Ghazvini

Poeschl

et al. 2004

International Journal of Oral and Maxillofacial Surgery

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Preoperative Radiochemotherapy and Radical Surgery of Advanced Head and Neck Cancers — Results of a Prospective, Multicenter DÖSAK Study

Cited by 13 publications

References 4 publications

Neoadjuvant Chemoradiotherapy for Oral Cavity Cancer: Predictive Factors for Response and Interim Analysis of the Prospective INVERT-Trial

Neoadjuvant Chemoradiotherapy for Oral Cavity Cancer: Predictive Factors for Response and Interim Analysis of the Prospective INVERT-Trial

Likelihood inference in complex settings

Two stage reconstruction with revascularized grafts after resection of retromolar and oropharyngeal carcinoma

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