Preoperative radiochemotherapy in the treatment of advanced oral cancer: Outcome of 276 patients

Combined-modality treatment in advanced oral squamous cell carcinoma

“…Our results indicate that primary surgery followed by adjuvant radiochemotherapy is suboptimal for patients with a UICC stage IVb OSCC [31]. During the last 10 years, a few studies evaluating the effect of neoadjuvant RCT in OSCC have been published but none has addressed the issue of possible differences between patients of the UICC stages IVa and IVb [18,22,26,28,32,33].…”

“…In addition, the inclusion criteria that define high-risk tumors vary between the different studies [6]. Several studies have examined the effects of neoadjuvant RCT followed by radical surgery on OSCC [19,22,26,33,39]. To the best of our knowledge, there is only one study that compared the results of adjuvant RT and RCT in advanced tongue carcinoma but no study that focuses on the effects adjuvant RCT in patients with squamous cell carcinoma from all sites of the oral cavity excluding tumors from other sites of the head and neck region [24].…”

Public awareness about prevention and early detection of oral cancer: A population-based study in Northern Germany

“…Although the oral cavity is easily accessible and an oral cancer examination can be done without discomfort to the patient, more than two-thirds of lesions are diagnosed at an advanced stage (Casiglia and Woo, 2001, Reichart, 2001, Patton et al, 2004, Laronde et al, 2008, Klug et al, 2008, Bianchi et al, 2009, Klug et al, 2009. Such lesions require aggressive treatment and result in a high mortality rate (Casiglia andWoo, 2001, Kowalski andCarvalho, 2001).…”

The role of elective supraomohyoidal neck dissection in the treatment of early, node-negative oral squamous cell carcinoma (OSCC): A retrospective analysis of 122 cases

“…To reduce morbidity, more selective surgical approaches including several types of selective neck dissection were developed (Ferlito et al, 2006;Zhang et al, in press). For the treatment of the clinically N0 neck, selective supraomohyoid neck dissection of level I, IIa and upper level III has been established as a safe surgical procedure with low morbidity to address the risk of occult metastases in oral cavity cancer (Klug et al, 2009;Kowalski and Sanabria, 2007). To see if this surgical procedure is also reasonable and efficient in early, locally circumscribed (i.e.…”