Preoperative Radiotherapy Combined with Capecitabine Chemotherapy in Chinese Patients with Locally Advanced Rectal Cancer

Jin, Jianhua; Meng, Hua; Zhou, Gan; Xu, Xuezhong; Xue, Zhonghui; Xu, Ximing; Wang, Fang; Li, Xianwen; Zhang, Hua; Deng, Jianzhong

doi:10.1007/s11605-011-1637-0

Cited by 4 publications

(5 citation statements)

References 34 publications

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“…It is noteworthy that our ypT0-2N0 downstaging rate compares favorably with other studies using capecitabine plus RT (ypT0-2N0 41.2–50%) [5, 12, 15, 20, 23–25]. Furthermore, other indices of tumor response (T/N downstaging, pCR) are comparable to other studies (Table 4) [5, 12, 15–26].…”

Section: Discussionsupporting

confidence: 84%

Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer

Chen

Huang

Tsai

et al. 2014

BioMed Research International

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The aim of this study was to evaluate the efficacy of helical tomotherapy plus capecitabine as a preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC). Thirty-six LARC patients receiving preoperative CRT were analyzed. Radiotherapy (RT) consisted of 45 Gy to the regional lymph nodes and simultaneous-integrated boost (SIB) 50.4 Gy to the tumor, 5 days/week for 5 weeks. Chemotherapy consisted of capecitabine 850 mg/m2, twice daily, during the RT days. Patients underwent surgery 6–8 weeks after completion of CRT. Information was collected for patient characteristics, treatment response, and acute and late toxicities. Grade 3/4 (G3+) toxicities occurred in 11.1% of patients (4/36). Sphincter preservation rate was 85.2% (23/27). Five patients (14.3%) achieved pathological complete response. Tumor, nodal, and ypT0-2N0 downstaging were noted in 60% (21/35), 69.6% (16/23), and 57.1% (20/35). Tumor regression grade 2~4 was achieved in 28 patients (80%). After a median follow-up time of 35 months, the most common G3+ late morbidity was ileus and fistula (5.7%, 2/35). The study showed that capecitabine plus helical tomotherapy with an SIB is feasible in treatment of LARC. The treatment modality can achieve a very encouraging sphincter preservation rate and a favorable ypT0-2N0 downstaging rate without excessive toxicity.

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Section: Discussionsupporting

confidence: 84%

Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer

Chen

Huang

Tsai

et al. 2014

BioMed Research International

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“…In China, most patients diagnosed as T3 or T4 rectal cancer [ 9 ], which is characterized by large tumor size and involvement of rectal fascial layers, and which leads to significantly difficult dissection in the bloodless plane as well as more technically challenging for laparoscopic surgery than early rectal cancer. The rate for severe complication after laparoscopic surgery for advanced-stage rectal cancer has been reported to be 22.5%, whereas the rate for early-stage rectal cancer was 2% [ 10 , 11 ], which suggested that risk factors of severe complications for advanced rectal cancer is different from that for early-staged rectal cancer after laparoscopic surgery.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Severe Complications After Laparoscopic Surgery for T3 or T4 Rectal Cancer for Chinese Patients: Experience from a Single Center

Liang

Liu

et al. 2020

Med Sci Monit

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Background Patients with rectal cancer are usually at advanced stage with or beyond serosa invasion in China. Severe complications after laparoscopic rectal surgery leads to prolonged hospitalization and high medical cost. This study aimed to explore risk factors for severe complications after laparoscopic surgery of T3 or T4 rectal cancer. Material/Methods A total of 287 patients diagnosed with T3 or T4 rectal cancer were enrolled from the Department of Gastrointestinal Surgery of Anhui Provincial Hospital from February 2012 to February 2017. Univariate analysis and multivariable logistic regression model were used to analyze the risk factors for severe complications (Clavien-Dindo grade ≥III) after laparoscopic surgery. Results Eighteen patients (6.25%) had severe complications; 15 patients were categorized as Clavien-Dindo grade III, and 3 patients were categorized as Clavien-Dindo grade IV. Univariate analysis showed that male gender, high preoperative white blood cells (WBC), diabetes mellitus, pulmonary dysfunction, and tumor distance from anus were associated with increased risk of severe complications after laparoscopic surgery for rectal cancer. Multivariate analysis showed that preoperative WBC ≥6.9×10 9 /L (OR=5.54 (1.58–19.45), P =0.008), diabetes mellitus (OR=13.07 (3.31–51.67), P =0.000) and pulmonary dysfunction (OR=7.75 (1.69–35.63), P =0.008) were independent risk factors for postoperative severe complications. Conclusions Preoperative high white blood cells, diabetes mellitus and pulmonary dysfunction were independent risk factors for severe complications after laparoscopic surgery for T3 or T4 rectal cancer.

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“…5,6,9,10,21,24,26 We have also found a posttreatment nodal involvement (30.7%) slightly higher than in other studies. 5,[8][9][10][11]14,24 total mesorectal excision was performed by the same senior surgical team 5 to 6 weeks after neoadjuvant treatment. sphincter preservation was achieved in 51 patients (60.2%) with low rectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7][8][9][10][11][12] on this basis, for locally advanced rectal cancer (laRC), neoadjuvant CRt followed by surgery is currently the preferred treatment option. 5,[13][14][15] adjuvant chemotherapy (Cht) is usually recommended, although controversy exists in patients who have been rendered node negative by preoperative treatment. 15,16 the multidisciplinary management of laRC has translated into a decrease in the rate of local failure.…”

mentioning

confidence: 99%

Prognosis Factors for Recurrence in Patients With Locally Advanced Rectal Cancer Preoperatively Treated With Chemoradiotherapy and Adjuvant Chemotherapy

Arredondo

Baixauli

Beorlegui

et al. 2013

Diseases of the Colon &Amp; Rectum

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Preoperative Radiotherapy Combined with Capecitabine Chemotherapy in Chinese Patients with Locally Advanced Rectal Cancer

Abstract: Preoperative chemoradiotherapy with capecitabine and RT appears to be a safe, well-tolerated, and effective neoadjuvant treatment modality for LARC.

Cited by 4 publications

References 34 publications

Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer

Helical Tomotherapy Combined with Capecitabine in the Preoperative Treatment of Locally Advanced Rectal Cancer

Risk Factors for Severe Complications After Laparoscopic Surgery for T3 or T4 Rectal Cancer for Chinese Patients: Experience from a Single Center

Prognosis Factors for Recurrence in Patients With Locally Advanced Rectal Cancer Preoperatively Treated With Chemoradiotherapy and Adjuvant Chemotherapy

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