Preoperative recovery sleep ameliorates postoperative cognitive dysfunction aggravated by sleep fragmentation in aged mice by enhancing EEG delta-wave activity and LFP theta oscillation in hippocampal CA1

Li, Yun; Hou, Shaowei; Li, Feixiang; Long, Siwen; Yang, Yue; Li, Yize; Zhao, Lina; Yu, Yonghao

doi:10.1016/j.brainresbull.2024.110945

Cited by 3 publications

(1 citation statement)

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“…In recent years, an increasing body of observational research has indicated that sleep disorders are a risk factor for frailty progression. Sleep difficulties can indicate a variety of diseases, including poor health, co-morbidities including cardiovascular illness ( 43 ), depressive symptoms ( 44 ), cognitive dysfunction ( 45 ), and functional limitations ( 46 ), all of which disrupt sleep and raise the chance of frailty.…”

Section: Discussionmentioning

confidence: 99%

Causality between sleep traits and the risk of frailty: a Mendelian randomization study

Deng,

Hu,

Duan

et al. 2024

Front. Public Health

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BackgroundResearch based on observation has demonstrated a relationship between sleep traits and frailty; however, it remains uncertain if this correlation indicates causation. The purpose of this study was to look at the causal relationship that exists between frailty and sleep traits.MethodUsing summaries from a genome-wide association study of self-reported sleep features and frailty index, we performed a bidirectional Mendelian randomization (MR) analysis. Examining the causal relationships between seven sleep-related traits and frailty was the goal. The major method used to calculate effect estimates was the inverse-variance weighted method, supplemented by the weighted median and MR-Egger approaches. The study investigated pleiotropy and heterogeneity using several methodologies, such as the MR-Egger intercept, the MR-PRESSO approach, and the Cochran’s Q test. We took multivariate Mendelian randomization and genetic correlations between related traits to enhance the confidence of the results. Furthermore, we used MRlap to correct for any estimation bias due to sample overlap.ResultsInsomnia, napping during the day, and sleep apnea syndrome exhibited a positive connection with the frailty index in forward MR analysis. Conversely, there is a negative link between getting up in the morning, snoring and sleep duration with the frailty index. During the reverse MR analysis, the frailty index exhibited a positive correlation with insomnia, napping during the day, and sleep apnea syndrome, while demonstrating a negative correlation with sleep duration. There was no direct correlation between snoring, chronotype, and frailty. In MVMR analyses, the causal effect of sleep characteristics on frailty indices remained consistent after adjusting for potential confounders including BMI, smoking, and triglycerides.ConclusionThe findings of our investigation yield novel evidence that substantiates the notion of a bidirectional causal connection between sleep traits and frailty. Through the optimization of sleep, it is potentially feasible to hinder, postpone, or even reverse the state of frailty, and we proposed relevant interventions.

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