Preoperative red blood cell distribution width as an independent prognostic factor in metastatic renal cell carcinoma

Wei, Zongjie; Zhang, Fan; Ma, Xin; He, Weiyang; Gou, Xin; Zhang, Xu; Xie, Yongpeng

doi:10.1016/j.tranon.2022.101486

Cited by 3 publications

(4 citation statements)

References 24 publications

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“…Earlier research has demonstrated a strong correlation between elevated levels of RWD and the likelihood of mortality in adult patients with sepsis, thus indicating its potential as a biomarker for sepsis prediction [29,30] . Furthermore, increased levels of RDW have been found to be independently linked to a worsened prognosis in individuals suffering from acute kidney failure [31,32] . This outcome can be elucidated by a reverse causation: individuals previously diagnosed with these ailments are likely to be undergoing treatment or may have adopted healthier behaviors; Consequently, despite their elevated all-cause mortality rate, their analytical parameters may have been effectively managed.…”

Section: Discussionmentioning

confidence: 99%

The Prognostic Value of Red Cell Distribution Width in Critically Ill Cerebral Infarction Patients: A Retrospective Cohort Study

Zhao,

Wu,

2024

JCNR

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Objective: Red blood cell distribution width (RDW) has been utilized as a prognostic indicator for mortality risk assessment in cardiovascular and cerebrovascular patients. Nevertheless, the prognostic significance of RDW in critically ill patients with cerebral infarction is yet to be investigated. The objective of this study is to examine the association between RDW and the risk of all-cause mortality in cerebral infarction patients admitted to the intensive care unit (ICU). Method: A retrospective cohort study was conducted using the Medical Information Mart for Intensive Care IV 2.2 (MIMIC-IV) intensive care dataset for data analysis. The main results were the all-cause mortality rates at 3 and 12 months of follow-up. Cumulative curves were plotted using the Kaplan-Meier method, and Cox proportional hazards analysis was used to examine the relationship between RDW and mortality rates in critically ill cerebral infarction patients. Results: The findings indicate that RDW serves as a significant prognostic factor for mortality risk in critically ill stroke patients, specifically at the 3 and 12-month follow-up periods. The observed correlation between increasing RDW levels and higher mortality rates among cerebral infarction patients further supports the potential utility of RDW as a predictive indicator. Conclusion: RDW emerges as an independent predictor of mortality risk during the 3 and 12-month follow-up periods for critically ill patients with cerebral infarction.

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Section: Discussionmentioning

confidence: 99%

The Prognostic Value of Red Cell Distribution Width in Critically Ill Cerebral Infarction Patients: A Retrospective Cohort Study

Zhao,

Wu,

2024

JCNR

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“…We read the article entitled “Preoperative red blood cell distribution width as an independent prognostic factor in metastatic renal cell carcinoma” by Z. Wei et al, which has recently been published in Translational Oncology [1] . We thank Wei and colleagues for their contribution to the literature exploring the potential use of the red blood cell distribution width (RDW) as a biomarker in renal cell carcinoma (RCC).…”

mentioning

confidence: 99%

“…Our search identified seven studies [1] , [2] , [3] , [4] , [5] , [6] , [7] ( Table 1 ), which were conducted in Turkey ( n = 3), China ( n = 2), Singapore ( n = 1), and Poland ( n = 1) and were published between 2014–2022. The design of the studies was retrospective cohort ( n = 6) or case-control ( n = 1), with sample sizes ranging from to 103–687 patients.…”

mentioning

confidence: 99%

“…These studies made claims regarding the potential use for RDW in (1) distinguishing RCC from benign renal lesions (renal cysts) [6] ; (2) predicting pathologic features of the tumor (e.g. grade, tumor size, stage) [3] , [4] , [5] , [6] , [7] ; and (3) predicting clinical behavior, including progression-free survival, overall survival, cancer-specific survival) [ 1 , 2 , 5 , 7 ]. The RDW cutoff values for these studies ranged from 13.1–15.65%.…”

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confidence: 99%

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Red blood cell distribution width and renal cell carcinoma: A comparative analysis of peer-reviewed studies

Frater

Hurley

2022

Translational Oncology

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Homologous Tumor Targeting Molybdenum‐Doped Prussian Blue for Enhancing Immunotherapy via PTT/CDT and Remodeled Tumor Immune Microenvironment

Ma,

Li,

Jia

et al. 2024

Adv Funct Materials

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Immunotherapy offers a promising avenue for reducing tumor metastasis and recurrence but faces challenges from the tumor immunosuppressive microenvironment (TIME) and restricted antigen presentation. To address these challenges, this study have developed an innovative approach utilizing molybdenum (Mo)‐doped Prussian blue nanoparticles coated with a cancer cell membrane (CCM), referred to as PMo@CCM. This novel nanoplatform excels in performing photothermal therapy (PTT), while the Mo and Fe components effectively deplete glutathione (GSH) and generate reactive oxygen species (ROS), thereby significantly enhancing chemodynamic therapy (CDT) and remodeling the TIME. The synergistic PTT/CDT approach not only induces tumor immunogenic cell death (ICD) but also facilitates antigen presentation. The CCM coating further supplies antigens and prompts dendritic cell (DC) maturation. This comprehensive strategy markedly enhances the effectiveness of immunotherapy, as evidenced by a significant increase in T cell activation. Moreover, the use of programmed cell death protein 1 antibodies (anti PD‐1) effectively blocks the PD‐1 immune checkpoint pathway. RNA sequencing analysis has identified genes associated with the observed substantial reduction in tumor growth. In conclusion, the PMo@CCM nanoplatform enables homologously targeted tumor synergistic therapy, guided by photothermal and magnetic resonance imaging (PTI&MRI), significantly impeding the progression of both primary and metastatic tumors.

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Preoperative red blood cell distribution width as an independent prognostic factor in metastatic renal cell carcinoma

Cited by 3 publications

References 24 publications

The Prognostic Value of Red Cell Distribution Width in Critically Ill Cerebral Infarction Patients: A Retrospective Cohort Study

The Prognostic Value of Red Cell Distribution Width in Critically Ill Cerebral Infarction Patients: A Retrospective Cohort Study

Red blood cell distribution width and renal cell carcinoma: A comparative analysis of peer-reviewed studies

Homologous Tumor Targeting Molybdenum‐Doped Prussian Blue for Enhancing Immunotherapy via PTT/CDT and Remodeled Tumor Immune Microenvironment

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