Preoperative sarcopenia status is associated with lymphovascular invasion in upper tract urothelial carcinoma patients treated with radical nephroureterectomy

Abstract

Introduction: Sarcopenia is a novel concept representing skeletal muscle wasting and

Prognostic value of radiologically determined sarcopenia prior to treatment in urologic tumors

“…As Figure 2 shown, the synthesized result suggested that sarcopenia was significantly associated with poor OS (Fixed-effect model, HR 1.73, 95% CI: 1.48–2.01, P <.05; heterogeneity: P = .064; I 2 = 40.5%). Additionally, there were 10 eligible studies with 1790 patients [23–26,28,29,32,40–42] that evaluated the relationship between sarcopenia and CSS in urologic tumors. Our synthesized analysis of these studies showed that there was also a significant correlation between sarcopenia and poor CSS (Fixed-effect model, HR: 1.85, 95% CI: 1.51–2.28, P <.05, heterogeneity: P = .053; I 2 = 46.2%) (Fig.…”

Impact of cachexia on oncologic outcomes of sarcopenic patients with upper tract urothelial carcinoma after radical nephroureterectomy

“…In a similar vein, in this retrospective study, patients with sarcopenia were significantly older than those without sarcopenia in the UTUC patient group treated with RNU. Many studies have reported the prognostic significance of sarcopenia for UTUC patients who underwent RNU [1][2][3] by comparing the outcomes of sarcopenic and non-sarcopenic patients. However, these studies did not evaluate another important condition that frequently occurs in cancer patients-cachexia.…”

“…Thus, identifying high-risk patients as candidates for adjunctive therapies is important to improve oncological outcomes. Host factors play an important role, but tumor factors including the pT and pN stages, tumor grade, and lymphovascular invasion are essential [1][2][3].…”