Preoperative serum CA125 is an independent predictor for prognosis in operable patients with non-small cell lung cancer

Abstract

The role of serum CA125 and CEA in the prognosis of non-small cell lung cancer (NSCLC) remains controversial, especially in early stage patients, which need further clarification. Thus, in this study we carried out a large scale retrospective analysis of the prognostic value of CA125 and CEA in 645 patients with NSCLC, to explore their predictive value in the NSCLC. Patients who underwent curative surgical resection for NSCLC were from Zhejiang Cancer Hospital of China from 2006 to 2011. Microparticle enzyme immunoassay was used to measure preoperative serum CA125 and CEA. Univariate analyses and a multivariable proportional hazard Cox regression model were applied to assess the prognostic significance of the different covariates. Kaplan-Meier method was used to analyze survival curve. Both CA125 and CEA were correlated with stage, but also CA125 was different by grade, and CEA was related to histology. The Kaplan-Meier survival analysis showed that patients with elevated CA125 or CEA had unfavorable disease progression-free and overall survival time compared to those with normal CA125 or CEA. Furthermore, multivariate Cox analysis revealed that elevated CA125 had significantly higher risk for relapse (HR, 1.76; p=0.001) and death (HR, 1.80; p<0.001), but not for elevated CEA as relapse (HR, 1.06; p=0.736) and death (HR, 1.25; p= 0.119) both were statistically non significant. This study showed that both CA125 and CEA play important roles in disease progression while only CA125 as an independent predictive marker for prognosis in patients with NSCLC.

Combined neat model for the prognosis of postoperative stage III‐N2 non‐small cell lung cancer

“…A correlation between high baseline levels of CA 125 and worse survival in advanced stage (III–IV) NSCLC patients has been previously reported 18 . However, it was not conclusive in predicting relapse and failures 15, 17, 19 . Our study demonstrated that CA 125 is the only independent indicator for OS, PFS, LRFS, and DMFS, both in univariate and multivariate analyses.…”

“…Compared with CEA and CYFRA 21‐1, there have been fewer studies on the relationship between CA 125 and survival. In operable NSCLC, serum CA 125 could be used as a tool to predict survival 15–17 . A correlation between high baseline levels of CA 125 and worse survival in advanced stage (III–IV) NSCLC patients has been previously reported 18 .…”

Correlation of neuroendocrine features with prognosis of non-small cell lung cancer

“…In China, the morbidity and mortality of lung cancer has been rising due to smoking and environmental deterioration in the past decades [3–6]. Despite the tremendous efforts and progress in lung cancer research, and the use of aggressive multimodal chemo- and radiotherapy, the overall treatment outcome for lung cancer patients remains poor.…”

Diagnostic Value of Epidermal Growth Factor, Cancer Antigen 125, and Cancer Antigen 15-3 in Bronchoalveolar Lavage Fluid of Lung Cancer

“…In a recent report, Ying et al 18 undertook FIGURE 1 Levels of epidermal growth factor (EGF) in bronchoalveolar lavage fluid. (A) Levels of EGF were significantly higher in patients with lung cancer than in patients with benign conditions (**p < 0.01 by t-test; the horizontal lines mark mean values).…”