Preoperative Serum Leptin Level Is Associated with Preoperative Pain Threshold and Postoperative Analgesic Consumption in Patients Undergoing Cesarean Section

Abstract

Objective: This study aimed to investigate the preoperative level of serum leptin in cesarean section (C-section) patients with and without acute labor pain and its association with postoperative analgesic consumption and preoperative pain threshold. Materials and Methods: Preoperative leptin levels, preoperative pain threshold, postoperative analgesic consumption in the first 24 h, and postoperative pain severity (visual analog scale (VAS) scores at 1, 2, 4, 6, 12, and 24 h postoperatively) in C-section patients with labor pain (emergency C-section; n = 21) and without labor pain (elective C-section; n = 25) were compared. Results: There were no significant differences between the groups regarding the demographic characteristics. Leptin levels, postoperative VAS scores, and analgesic consumption were significantly higher in the group with labor pain, while the preoperative pain threshold was lower. Serum leptin levels correlated negatively with pain threshold and positively with postoperative analgesic consumption. Multiple linear regression analyses in our study revealed that the preoperative leptin levels and having an emergency C-section independently affected the postoperative analgesic consumption and preoperative pain threshold, whereas their combined effects on these parameters were statistically not significant. Conclusion: Preoperative levels of serum leptin were higher in C-section patients with labor pain than in those without labor pain, and increased serum leptin levels were associated with decreased preoperative pain threshold and increased postoperative analgesic consumption in our study population. Postoperative analgesic requirements may vary among patients, and their requirements might be predicted using preoperative indicators. Serum levels of leptin might be one such indicator and this warrants further studies with larger sample sizes.

Effect of Personality and Pain Catastrophizing on Postoperative Analgesia Following Cesarean Section: A Prospective Cohort Study

“… 26 Recent studies have focused on the development of more objective predictors to evaluate pain after cesarean section. 27 , 28 On the one hand, postoperative pain affects maternal mental health, increases healing time, and reduces early mobility and functional activities, thereby increasing the length of hospital stay and leading to chronic postoperative pain. 29 , 30 However, it also prolongs the mother-infant relationship, affects breastfeeding, and affects the growth and development of newborns.…”

Ultrasound-guided thoracic paravertebral block for percutaneous kyphoplasty: A prospective non-randomized comparative study

“…However, the method for determining if the patient would receive paravertebral blocks or local anesthesia infiltration preoperative is still controversial. Several studies proposed to predict the amount of postoperative analgesics in patients by measuring the sensitivity of preoperative patients to pain, anxiety, pain threshold, pain tolanrance threshold [18][19][20][21] . Thus, studies on the indication of paravertebral blocks and local infiltration anesthesia for PKP will be included in our future work.…”

Label-free serum proteomics for the identification of the putative biomarkers of postoperative pain in patients with gastric cancer

“…Measurement of biomarkers prior to an operation may be useful in predicting analgesic consumption and improving postoperative pain management. 10…”

“…may be useful in predicting analgesic consumption and improving postoperative pain management. 10 Several studies have shown that preoperative levels of proteins or cytokines are associated with postoperative pain intensity or analgesic consumption, 10 and may potentially function as biomarkers to predict pain intensity. Proteins in the intracellular and extracellular matrix can act as biochemical alarmins for the immune system.…”

“…12 Nurten et al showed that preoperative serum leptin is associated with postoperative analgesic dosage in patients after cesarean section. 10 Zietek et al showed that higher levels of tumor necrosis factor in synovial fluid were negatively associated with knee pain after fast-track total knee arthroplasty (TKA). 13 Si et al found that markers of muscle damage (myoglobin, creatine kinase, and lactate dehydrogenase) were positively correlated with postoperative pain after TKA.…”