Preoperative serum SCC, CA125, and CA19‐9 levels and lymph node status in squamous cell carcinoma of the uterine cervix

Takeda, Mahito; Sakuragi, Noriaki; Okamoto, Kazuhira; Todo, Yukiharu; Minobe, Shinichiro; Nomura, Eiji; Negishi, H.; Oikawa, Mamoru; Yamamoto, Ritsu; Fujimoto, Seiichiro

doi:10.1034/j.1600-0412.2002.810513.x

Cited by 81 publications

(61 citation statements)

References 16 publications

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“…More candidates should be enroled in further studies to realise the differences of serum levels of IGF-1 between normal individuals, patients with precancer lesions and cervical cancer. Pretreatment SCC Ag or CEA assays, as tumour-associated antigens, have been identified to be valuable in distinguishing high-risk patients requiring adjuvant therapy and in predicting prognosis in early-stage cervical cancer (Bae et al, 1997;Takeda et al, 2002;Reesink-Peters et al, 2005). In our cohorts, the integration of SCC Ag level and IGF-1R overexpression or the combination of CEA and IGF-1 levels could produce more accurate estimates in identifying patient subgroups of poor prognosis.…”

Section: Discussionmentioning

confidence: 90%

Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer

et al. 2008

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This study was aimed to identify the expression and the correlation of insulin-like growth factor-1 (IGF-1) system and their prognostic impacts in cervical cancer. Seventy-two patients with early-stage cervical cancer were eligible. We obtained the serum levels of total IGF-1 and IGF binding protein-3 (IGFBP-3) by enzyme-linked immunosorbent assay and the expression of IGF-1 receptor (IGF-1R) in cancerous tissue by immuno-fluorescent (IF) stains. The 5-year recurrence-free and overall survival rates were significantly lower (P ¼ 0.003 and P ¼ 0.01, respectively) among patients with high-grade expression of tissue IGF-1R, compared with those with low-grade expression. After adjustment for other factors, preoperative serum total IGF-1 or IGFBP-3 levels failed to predict cancer death and recurrence. High-grade expression of IGF-1R and elevated preoperative squamous cell carcinoma antigen level were independent predictors of both death and recurrence, and combination of both factors could further help identify the subgroup of patients at higher death risk. The IF staining indicates the colocalisation of IGF-1 and IGF-1R in the cancerous tissues, whereas the IGF-1R expression is not correlated with circulating levels of IGF-1 or IGFBP-3. In early-stage cervical cancer, IGF-1 system may have a paracrine or autocrine function and the adverse impacts on prognosis by IGF-1R overexpression are implicated.

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Section: Discussionmentioning

confidence: 90%

Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer

et al. 2008

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“…Zhang et al [6] also studied the biomarkers CA19-9, CA15-3 and their statistical correlation was not significant in Ovarian Cancer and did not corresponded with the clinical course of the disease. Vistintin et al [7] found the levels of leptin, prolactin, osteopontin to be 95% sensitive and 99% specific in Ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Early Diagnosis of Gynecological Cancers in Ladies with Review of Literature

Mukherjee¹,

Mukherjee²,

Dutta³

2017

OJOG

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The most prevalent cancers in ladies are cervical, endometrial and Ovarian. The biomarkers prevalent in use for these gynaecological cancers are commonly Cancer antigen 125 (CA-125), B, Alpha-fetoprotein (AFP), Inhibin, Carcinoembryonic antigen (CEA), Squamous cell carcinoma (SCC) antigen, Carbohydrate antigen 19-9, Cancer antigen 27-29, Human epididymis protein 4 (HE4), Osteopontin, transthyretin, Immunosuppressive acidic protein(IAP), leptin, CA15-3, CK19 and Thymidine kinase. The biomarker marker Squamous cell carcinoma (SCC) antigen, CK19 and immunosuppressive acidic protein IAP are raised in cervical squamous cell carcinomas. Endometrial cancer is a common cancer in women. In 75% of endometrial cancer cases, the tumor remains confined to the uterus and has a favorable prognosis if early detected. The prognosis, however, worsens dramatically as the disease progresses. The objective of this review is to elucidate the importance of the tumor markers for early diagnosis of gynaecological malignancies which are vital and life saving. Similarly the relevant biomarkers in combination are found to have positive predictive values and significant p values in the endometrial and cervical cancer. In Cervix cancer the positive predictive value of these markers combined is usually 92% -95% and negative predictive value 93% -96%. The confidence interval is 98% and p value significant 0.005. Sensitivity of tumor markers combined CK19, SCC and immunosuppressive acidic protein IAP in Cervix cancer detection is 95% and specificity 96%. The highest sensitivity was for SCC antigen (98.7%) while the highest specificity was for Cytokeratin 19 (99.7%). The positive predictive value by combination of CK19, SCC and IAP for the detection of Cervix cancer was 90% -94%. In endometrial cancer the sensitivity of tumor markers combined CA19-9, CA125, leptin, thymidine kinase, CEA, CA15-3, and HE4 in endometrial cancer detection was 95% and specificity 96%. The highest sensitivity was for CA125 (99.7%) while the highest specificity was for CA19-9 (95.7%) which revealed that the efficacy of

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“…Although Gaarenstroom et al suggested a relationship between pre-treatment Cyfra 21-1, TPA, SCC antigen levels and tumor size, and concluded that this was insufficient for identifying patients at risk for the presence of lymph node metastases or parametrial involvement (9), Taketa et al stated that pre-treatment analysis of the DTM index (double-tumor marker index) of SCC and CA125 levels allows estimation of lymph node status and prognosis for patients with cervical squamous cell carcinoma (13). In this study we were able to further these findings by showing that there was a significant relationship between the two tumor markers and the prognostic factors FIGO stage, lesion size, lymph node metastasis, and parametrial involvement.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Pre-treatment Serum SCC (squamous cell carcinoma) Antigen, Cyfra 21-1 Levels, and Survival in Squamous Cell Carcinoma of the Uterine Cervix

et al. 2005

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Purpose: To determine the relationship between pretreatment serum squamous cell carcinoma (SCC) antigen and Cyfra 21-1 levels, and survival in patients with invasive squamous cell carcinoma of the cervix.Materials and Methods: One hundred and one cervical squamous cell carcinoma patients were included. Pre-treatment levels of serum SCC antigen and Cyfra 21-1 were measured, with a 5 year minimum follow up. Thirty two recurrent disease (RD) patients were compared to 99 non-recurrent disease (NRD) patients with respect to tumor markers, FIGO stage, lesion size, lymph node status, and parametrial involvement.Results: Pre-treatment serum SCC antigen and Cyfra 21-1 levels were significantly higher in the RD group (p＜ 0.001). Combined serum SCC antigen and Cyfra 21-1 levels showed higher sensitivity for prediction of recurrence (90.6% ). Pre-treatment SCC antigen and Cyfra 21-1 levels showed correlation with high FIGO stage, large lesion size, lymph node status, and parametrial involvement (p＜0.001). Normal pre-treatment levels of SCC antigen and Cyfra 21-1 showed a 5-year survival rate of 93% and 90% respectively, while elevated levels showed significantly decreased survival rate of 63% and 59% , respectively (p＜0.001). Odd ratio for cumulative survival rates were 6.87 for SCC antigen, and 5.07 for Cyfra 21-1 (p＜0.001).Conclusion

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Preoperative serum SCC, CA125, and CA19‐9 levels and lymph node status in squamous cell carcinoma of the uterine cervix

Abstract: Combination assay of pretreatment serum SCC and CA125 levels seems to be useful in estimating lymph node status and the prognosis for patients with cervical SCC in a preoperative setting.

Cited by 81 publications

References 16 publications

Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer

Clinical implications of insulin-like growth factor 1 system in early-stage cervical cancer

Early Diagnosis of Gynecological Cancers in Ladies with Review of Literature

Relationship between Pre-treatment Serum SCC (squamous cell carcinoma) Antigen, Cyfra 21-1 Levels, and Survival in Squamous Cell Carcinoma of the Uterine Cervix

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