Preoperative single-dose camrelizumab and/or microwave ablation in women with early-stage breast cancer: A window-of-opportunity trial

Pan, Hong; Yu, Muxin; Tang, Xinyu; Mao, Xinrui; Liu, Mingduo; Zhang, Kai; Qian, Chao; Wang, Ji; Xie, Hui; Qiu, Wen; Ding, Qiang; Wang, Shui; Zhou, Wenbin

doi:10.1016/j.medj.2024.01.015

Cited by 3 publications

(2 citation statements)

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“…Surgery of solid cancers has shifted toward more precise and minimally invasive treatment strategies, driven by advancements in fluorescence imaging-guided nanotechnology and systemic therapies 34 - 36 . This trend is also reflected in the exploration of breast surgery de-escalation and omission over the past decades 2 - 10 . A substantial portion of early BC patients, including those with DCIS, microinvasion, and those with favorable responses to neoadjuvant therapy, are potential candidates for minimally invasive local treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, some patients, even after a pathologic complete response (pCR), may require extensive resections, and high-risk individuals may opt for prophylactic mastectomy 3 - 6 . Recent preclinical and clinical studies have explored de-escalation or omission of breast surgery for these patients 7 - 10 . An urgent need exists for efficient and precise non-invasive strategies in BC personalized local therapy.…”

Section: Introductionmentioning

confidence: 99%

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Intraductal photothermal ablation: a noninvasive approach for early breast cancer treatment and prevention

Liu,

Huang,

Rao

et al. 2024

Theranostics

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Background: Innovative treatment strategies for early-stage breast cancer (BC) are urgently needed. Tumors originating from mammary ductal cells present an opportunity for targeted intervention. Methods: We explored intraductal therapy via natural nipple openings as a promising non-invasive approach for early BC. Using functional Near-infrared II (NIR-II) nanomaterials, specifically NIR-IIb quantum dots conjugated with Epep polypeptide for ductal cell targeting, we conducted in situ imaging and photothermal ablation of mammary ducts. Intraductal administration was followed by stimulation with an 808 nm laser. Results: This method achieved precise ductal destruction and heightened immunological responses in the microenvironment. The technique was validated in mouse models of triple-negative BC and a rat model of ductal carcinoma in situ , demonstrating promising therapeutic potential for localized BC treatment and prevention. Conclusion: Our study demonstrated the effectiveness of NIR-II nanoprobes in guiding non-invasive photothermal ablation of mammary ducts, offering a compelling avenue for early-stage BC therapy.

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