Preoperative Staging of Non–Small-Cell Lung Cancer with Positron-Emission Tomography

Pieterman, RM; Putten, Jwg van; Meuzelaar, JJ; Mooyaart, E. L.; Vaalburg, W; Koeter, GH; Fidler,; Pruim, Jan; Groen, Henk

doi:10.1056/nejm200007273430404

Cited by 1,010 publications

(473 citation statements)

References 16 publications

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“…The high NPV of 18 F-FDG PET/CT (up to 97%) for mediastinal disease69–71 has led to the recommendation to omit mediastinoscopy in patients with negative mediastinal 18 F-FDG PET/CT 707273. However, special attention should be paid to central tumors, which have a high incidence of occult N2 disease 74.…”

Section: Methodsmentioning

confidence: 99%

¹⁸F-FDG PET/CT Imaging In Oncology

Almuhaideb

Παπαθανασίου

Bomanji

2011

Annals of Saudi Medicine

286

123

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Accurate diagnosis and staging are essential for the optimal management of cancer patients. Positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro- D-glucose integrated with computed tomography (18F-FDG PET/CT) has emerged as a powerful imaging tool for the detection of various cancers. The combined acquisition of PET and CT has synergistic advantages over PET or CT alone and minimizes their individual limitations. It is a valuable tool for staging and restaging of some tumors and has an important role in the detection of recurrence in asymptomatic patients with rising tumor marker levels and patients with negative or equivocal findings on conventional imaging techniques. It also allows for monitoring response to therapy and permitting timely modification of therapeutic regimens. In about 27% of the patients, the course of managment is changed. This review provides guidance for oncologists/ radiotherapists and clinical and surgical specialists on the use of 18F-FDG PET/CT in oncology.

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Section: Methodsmentioning

confidence: 99%

¹⁸F-FDG PET/CT Imaging In Oncology

Almuhaideb

Παπαθανασίου

Bomanji

2011

Annals of Saudi Medicine

286

123

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“…For example, PET has been shown to have greater sensitivity and specificity than either CT or magnetic resonance imaging in the staging of lung cancer. ( 3 – 5 ) The delineation of lung‐tumor boundaries in CT images can be complicated by the presence of atelectasis, pleural effusion, pneumonitis, and displacement of normal tissue. Lymph node involvement, which is always of concern, is difficult to distinguish using CT scans alone.…”

Section: Introductionmentioning

confidence: 99%

Comparison of three image segmentation techniques for target volume delineation in positron emission tomography

Drever

Roa²,

McEwan³

et al. 2007

J Applied Clin Med Phys

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Incorporation of positron emission tomography (PET) data into radiotherapy planning is currently under investigation for numerous sites including lung, brain, head and neck, breast, and prostate. Accurate tumor‐volume quantification is essential to the proper utilization of the unique information provided by PET. Unfortunately, target delineation within PET currently remains a largely unaddressed problem. We therefore examined the ability of three segmentation methods—thresholding, Sobel edge detection, and the watershed approach—to yield accurate delineation of PET target cross‐sections. A phantom study employing well‐defined cylindrical and spherical volumes and activity distributions provided an opportunity to assess the relative efficacy with which the three approaches could yield accurate target delineation in PET. Results revealed that threshold segmentation can accurately delineate target cross‐sections, but that the Sobel and watershed techniques both consistently fail to correctly identify the size of experimental volumes. The usefulness of threshold‐based segmentation is limited, however, by the dependence of the correct threshold (that which returns the correct area at each image slice) on target size.PACS numbers: 87.58.Fg, 87.57.Nk

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“…Prevention of unnecessary surgical interventions has been reported to occur in up to 14% of patients [9]. Recently, a randomized study has shown that the number of futile thoracotomies was significantly reduced in 19/82 patients compared to 29/96 patients, based on the addition of fluorodeoxyglucose (FDG) PET to the diagnostic algorithm [8].…”

mentioning

confidence: 99%

PET/CT for staging lung cancer: costly or cost-saving?

Buck

Herrmann

Schreyögg

2011

Eur J Nucl Med Mol Imaging

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Preoperative Staging of Non–Small-Cell Lung Cancer with Positron-Emission Tomography

Abstract: PET improves the rate of detection of local and distant metastases in patients with non-small-cell lung cancer.

Cited by 1,010 publications

References 16 publications

¹⁸F-FDG PET/CT Imaging In Oncology

¹⁸F-FDG PET/CT Imaging In Oncology

Comparison of three image segmentation techniques for target volume delineation in positron emission tomography

PET/CT for staging lung cancer: costly or cost-saving?

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Preoperative Staging of Non–Small-Cell Lung Cancer with Positron-Emission Tomography

Abstract: PET improves the rate of detection of local and distant metastases in patients with non-small-cell lung cancer.

Cited by 1,010 publications

References 16 publications

18F-FDG PET/CT Imaging In Oncology

18F-FDG PET/CT Imaging In Oncology

Comparison of three image segmentation techniques for target volume delineation in positron emission tomography

PET/CT for staging lung cancer: costly or cost-saving?

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Product

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¹⁸F-FDG PET/CT Imaging In Oncology

¹⁸F-FDG PET/CT Imaging In Oncology