Preoperative statin therapy for patients undergoing cardiac surgery

Kuhn, Elmar; Slottosch, Ingo; Wahlers, Thorsten; Liakopoulos, Oliver J.

doi:10.1002/14651858.cd008493.pub4

Cited by 6 publications

(3 citation statements)

References 131 publications

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“…For example, only same of the trials were designed with a prespecified postoperative AF as an outcome (16,29,30), and only one trial (29) included an intention-to-treat analysis of the effect on AF as detected in a systematic and blinded manner. Furthermore, a recent systematic Cochrane review of those trials showed evidence of selective reporting and publication bias (31). The suggestion that perioperative statin therapy might be associated with less severe myocardial damage derives from one randomized, placebocontrolled trial involving 200 patients undergoing CABG surgery (32) and from a non-blinded randomized trial involving 151 patients undergoing non-coronary cardiac surgery, which also reported improved left ventricular function (17).…”

Section: Discussionmentioning

confidence: 99%

The statin therapy to prevent atrial fibrillation after cardiac surgery: Shakespearean dilemma

Calcagno¹,

Stio²,

Mancone³

et al. 2016

J. Thorac. Dis.

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Section: Discussionmentioning

confidence: 99%

The statin therapy to prevent atrial fibrillation after cardiac surgery: Shakespearean dilemma

Calcagno¹,

Stio²,

Mancone³

et al. 2016

J. Thorac. Dis.

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“…Точно так же Kuhn и соавт. выявили 17 рандомизированных контролируемых испытаний, включающих в общей сложности 2138 участников [20]. Они обнаружили, что предоперационная терапия статинами снижает вероятность послеоперационной фибрилляции предсердий и сокращает пребывание пациента в отделении интенсивной терапии (ОИТ), а также в больнице.…”

Section: статины и операции на сердцеunclassified

О Значении Плейотропных Эффектов Статинов В Периоперационном Периоде При Операциях На Сердце

Чаулин¹,

Ваньков²

2022

ТРНиО

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Статины оказывают гиполипидемическое действие, что помогает контролировать гиперлипидемию. Кроме того, статины могут оказывать плейотропные эффекты, в частности, улучшение функции эндотелия сосудов, ингибирование окислительного стресса и противовоспалительные эффекты. Данные эффекты статинов могут играть важную роль в клинической практике. В статье рассмотрено значение плейотропных эффектов статинов в периоперационном периоде при операциях на сердце.

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“…Statin have been expected to reduce the development of AKI or atrial fibrillation following cardiac surgery based on its antioxidant and anti-inflammatory effects. The results from several randomized trial demonstrated that perioperative statin treatment in patients with undergo cardiac surgery reduced the development of postoperative atrial fibrillation with decreasing the concentration of inflammatory cytokines (7,8). Several observational cohort studies focusing on statin treatment as a preventive effect of AKI have been reported with conflicting results (3,4).…”

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confidence: 99%

No recommendation of routine perioperative statin use for prevention of acute kidney injury in patients undergoing cardiac surgery

2016

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Acute kidney injury (AKI) develops up to approximately 30% of patients who undergo cardiac surgery (1), and independently associating with increased risk of morbidity and mortality (1,2). The prevention of AKI following cardiac surgery is predominantly important. Statin have been expected to reduce the development of AKI following cardiac surgery based on its anti-inflammatory effects. However, several observational cohort studies focusing on statin treatment as a preventive effect of AKI have been reported with conflicting results (3,4). Retrospective studies might have limitations of inevitable selection bias, and leading into the possibility of misleading and inconclusive results. To date, there is little evidence from randomized trials in populations receiving cardiac surgery to support the role of perioperative statin treatment to prevent AKI.Recently, Billings and colleagues conducted the prospective double-blinded randomized controlled trial of a perioperative statin for prevention of AKI following cardiac surgery (5). Their hypothesis was that perioperative statin would reduce AKI following cardiac surgery by 30% as compared to placebo with an assumed AKI incidence of 27.6% in the placebo group, a type I error probability of 0.05, and 80% power. They enrolled a total of 615 patients (199 naïve to statin treatment and 416 already taking a statin). Enrolled patients were randomized to perioperative statin treatment (80 mg of atorvastatin the day prior surgery, 40 mg of atorvastatin the morning of surgery, and 40 mg of atorvastatin daily following surgery for the duration of hospitalization) or placebo. If patients already taking statin, their pre-enrollment statin was continued until the day of surgery and resumed taking their previously prescribed statin on postoperative day 2 because of ethical issue. The primary endpoint was the incidence of AKI, which was defined as an increase of 0.3 mg/dL in serum creatinine concentration or the initiation of renal replacement therapy within 48 hours of surgery.The data and safety monitoring board recommended stopping the group naïve to statin treatment due to increased AKI among these participants with chronic kidney disease (CKD), defined as an estimated glomerular filtration rate <60 mL/min/1.73 m 2 , receiving atorvastatin. Summary of study results are shown in

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Preoperative statin therapy for patients undergoing cardiac surgery

Abstract: Preoperative statin therapy for patients undergoing cardiac surgery.

Cited by 6 publications

References 131 publications

The statin therapy to prevent atrial fibrillation after cardiac surgery: Shakespearean dilemma

The statin therapy to prevent atrial fibrillation after cardiac surgery: Shakespearean dilemma

О Значении Плейотропных Эффектов Статинов В Периоперационном Периоде При Операциях На Сердце

No recommendation of routine perioperative statin use for prevention of acute kidney injury in patients undergoing cardiac surgery

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