Preoperative systemic immune‐inflammation index as a significant prognostic factor after <scp>TURBT</scp> in patients with non‐muscle‐invasive bladder cancer: A retrospective study based on propensity score matching analysis

Ding, Li; Wang, Xiangbu; Deng, Xiaobin; Xia, Wentao; Wang, Kun; Yu, Xianlin; Huang, Ye; Wang, Junqi

doi:10.1002/cam4.5501

Cited by 5 publications

(5 citation statements)

References 41 publications

(79 reference statements)

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“…11 studies (involving 12 datasets) comprising 10577 patients reported on the prognostic effect of preoperative SII on RFS in UC patients ( 11 , 13 , 18 , 19 , 23 , 24 , 26 , 27 , 29 , 30 , 32 ). The pooled analysis demonstrated that higher preoperative SII in UC patients was an independent predictor of RFS (HR = 1.240, 95% CI 1.097-1.403, p=0.001), with significant heterogeneity (I 2 = 78.0%, p<0.001) ( Figure 4 , Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…After having read the titles and abstracts, 35 potentially eligible papers underwent full-text reviewing. Finally, 19 studies that comprised 12505 patients were included in this meta-analysis (11,(13)(14)(15)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). All the included studies have been published within the last 5 years (2019-2023); 13 studies focused on BC, 5 studies about UTUC, and the last one was on mixed (BC and 1.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Preoperative systemic immune-inflammation index as a prognostic indicator for patients with urothelial carcinoma

Zheng,

Peng,

Zhang

et al. 2023

Front. Immunol.

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BackgroundThe systemic immune-inflammation index (SII) is a cost-efficient indicator for carcinoma prognosis. However, its utility in urothelial carcinoma (UC) prognosis is disputed. This meta-analysis aims to assess SII’s prognostic value in UC.MethodsA thorough search of databases including PubMed, Web of Science, Embase, Cochrane Library, and Scopus, was conducted to find studies until January 11, 2023. Eligibility criteria were applied to select studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted from selected studies and compiled in a meta-analysis to gauge SII’s association with survival outcomes such as overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS), and progression-free survival (PFS).ResultsThis analysis includes 19 studies with 12505 UC patients. It was found that high SII significantly correlated with worse OS in UC patients (HR 1.430, 95% CI 1.237-1.653, P<0.001). High SII values also linked with poorer CSS (HR 1.913, 95% CI 1.473-2.485, P<0.001), RFS (HR 1.240, 95% CI 1.097-1.403, P=0.001), and PFS (HR 1.844, 95% CI 1.488-2.284, P<0.001) compared to low SII values. Subgroup analysis revealed SII’s consistent prognostic value in UC across races, carcinoma types, sample sizes, and SII cut-off values, suggesting its potential as a prognostic indicator in UC patients.ConclusionCurrent evidence suggests SII as a promising, cost-efficient predictor in UC patients. This meta-analysis indicates SII’s potential as a valuable prognostic tool in UC patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=307643, identifier CRD42022307643.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Preoperative systemic immune-inflammation index as a prognostic indicator for patients with urothelial carcinoma

Zheng,

Peng,

Zhang

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Finally, 19 studies that comprised 12505 patients were included in this meta-analysis [10,[12][13][14][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. All the included studies have been published within the last 5 years (2019-2023); 13 studies focused on BC, 5 studies about UTUC, and the last one on mixed(BC and UTUC).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Prognostic signi cance of SII on RFS in patients With UC 11 studies (involving 12 datasets) comprising 10577 patients reported on the prognostic effect of preoperative SII on RFS in UC patients [10,12,17,18,22,23,25,26,28,29,31]. The pooled analysis demonstrated that higher preoperative SII in UC patients was an independent predictor of RFS (HR = 1.240, 95% CI 1.097-1.403, p = 0.001), with signi cant heterogeneity (I 2 = 78.0%, p < 0.001) (Fig.…”

Section: Study Characteristicsmentioning

confidence: 99%

Preoperative Systemic immune-inflammation index as a prognostic indicator for patients with urothelial carcinoma

Zheng,

Peng,

Zhang

et al. 2023

Preprint

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Background The systemic immune-inflammation index (SII) is a cost-efficient indicator for carcinoma prognosis. However, its utility in urothelial carcinoma (UC) prognosis is disputed. This meta-analysis aims to assess SII's prognostic value in UC. Methods A thorough search of databases including PubMed, Web of Science, Embase, Cochrane Library, and Scopus, was conducted to find studies until January 11, 2023. Eligibility criteria were applied to select studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted from selected studies and compiled in a meta-analysis to gauge SII's association with survival outcomes such as overall survival (OS), cancer-specific survival (CSS), recurrence-free survival (RFS), and progression-free survival (PFS). Results This analysis includes 19 studies with 11,348 UC patients. It was found that high SII significantly correlated with worse OS in UC patients (HR 1.430, 95% CI 1.237–1.653, P < 0.001). High SII values also linked with poorer CSS (HR 1.913, 95% CI 1.473–2.485, P < 0.001), RFS (HR 1.240, 95% CI 1.097–1.403, P < 0.001), and PFS (HR 1.844, 95% CI 1.488–2.284, P < 0.001) compared to low SII values. Subgroup analysis revealed SII's consistent prognostic value in UC across races, carcinoma types, sample sizes, and SII cut-off values, suggesting its potential as a prognostic indicator in UC patients. Conclusions Current evidence suggests SII as a promising, cost-efficient predictor in UC patients. This meta-analysis indicates SII's potential as a valuable prognostication tool in UC patients.

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“…As in many previous studies, the SII is an important tool for predicting the prognosis and survival rate of patients with malignant tumors, spontaneous cerebral hemorrhage, and cerebral infarction. This index could provide an accurate assessment of a patient's inflammatory and immune status, allowing clinicians to gain a better understanding of the patient's condition and develop an appropriate treatment plan [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The association of systemic immune-inflammation index with lung function, risk of COPD and COPD severity: A population-based study

Song,

Bai,

2024

PLoS ONE

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Purpose The relationship between the levels of Systemic Immune-inflammation Index (SII) and chronic obstructive pulmonary disease (COPD), lung function, and COPD severity were not fully understood. We conducted this cross-sectional, population-based study to investigate the complex association between SII and COPD, lung function, and COPD severity among the US adults. Methods Overall, 18,349 participants were included in the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. The exposure variable was SII, calculated from platelet counts, neutrophil counts, and lymphocyte counts. Weighted univariable and multivariable logistic regression, subgroup analysis, and restricted cubic spline (RCS) regression were performed to assess the relationship between COPD, lung function, COPD severity and SII. Last, we used a propensity score matching (PSM) analysis to reduce selective bias and validate these relationships. Results Approximately 1,094 (5.96%) of the participants were diagnosed as COPD. The multivariable-adjusted odds ratio (OR) (95% confidence interval, CI) for the Q2 group (Log-SII > 2.740) was 1.39 (1.16 to 1.68). Before and after matching, multivariable logistic regression models revealed that increased Log-SII levels (SII Logarithmic transformation) associated positively with the risk of COPD. The subgroup analysis showed no interaction between Log-SII and a variety of variables (P for interaction > 0.05). RCS showed a reversed L-shaped relationship between Log-SII with COPD (P for nonlinear = 0.001) in individuals. In addition, we observed negative significant correlations between forced expiratory volume in one second (FEV1) / forced vital capacity (FVC) %, FEV1/FVC% predicted and SII, and reversed U-shaped curve relationships between FEV1, FEV1% predicted and SII. High SII level is associated with severity of COPD, especially at Global Initiative on Obstructive Lung Disease (GOLD) 1 and GOLD 3. Conclusions In summary, the Log-SII level is associated with COPD risk, lung function, and COPD severity.

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Preoperative systemic immune‐inflammation index as a significant prognostic factor after TURBT in patients with non‐muscle‐invasive bladder cancer: A retrospective study based on propensity score matching analysis

Cited by 5 publications

References 41 publications

Preoperative systemic immune-inflammation index as a prognostic indicator for patients with urothelial carcinoma

Preoperative systemic immune-inflammation index as a prognostic indicator for patients with urothelial carcinoma

Preoperative Systemic immune-inflammation index as a prognostic indicator for patients with urothelial carcinoma

The association of systemic immune-inflammation index with lung function, risk of COPD and COPD severity: A population-based study

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