Preoperative Thrombocytosis and Poor Prognostic Factors in Endometrial Cancer

Heng, Suttichai; Benjapibal, Mongkol

doi:10.7314/apjcp.2014.15.23.10231

Cited by 28 publications

(28 citation statements)

References 26 publications

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“…Although thrombocytosis has been reported in patients with gastric (35), lung (36) and endometrial cancer (37), the association between thrombocytosis and the clinicopathological features of patients with colorectal cancer has not been fully investigated and the molecular mechanism of platelets affecting cancer metastasis remain unclear. Vascularization within a tumor is a portal through which tumor cells enter the bloodstream to disseminate.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of coagulation factors in operable colorectal cancer

Lee

Huh

et al. 2017

Oncology Letters

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Abnormal hemostasis in cancer patients has prev iously been studied. The primary objective of the present study was to evaluate the association between preoperative hemostasis markers and clinicopathological parameters, and to identify a hemostasis marker affecting survival in patients following curative resection for colorectal cancer. A total of 170 patients who underwent curative surgery for colorectal carcinoma were evaluated. Preoperative coagulation tests included platelet, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer and fibrinogen degradation product (FDP). The clinicopathological variables, including age, gender, tumor location (rectum/colon), tumor size (≥5 cm vs. <5 cm), depth of tumor invasion, lymph node metastasis, stage, lymphovascular invasion, margin involvement and histological differentiation were analyzed. The median age of analyzed patients was 63 years (range, 28–84). The male to female ratio was 62:38. Increased levels of plasma fibrinogen, PT and platelet count (PLT) were associated with larger tumor size (P<0.001, P=0.015 and P=0.002, respectively). Increased plasma fibrinogen levels were significantly associated with depth of tumor invasion and stage (P=0.014 and P=0.048, respectively). Increased plasma D-dimer and FDP levels were significantly associated with tumor node metastasis stage (P=0.031 and P=0.002, respectively). Prolonged PT level (≥11.7 sec), hyper-fibrinogenemia (≥327 mg/dl), high D-dimer level (≥1.3 µg/ml) and increased FDP level (≥2.7 µg/ml) were the prognostic factors associated with shorter survival. Preoperative plasma fibrinogen level was significantly associated with tumor size and depth of tumor invasion. Preoperative plasma prolonged PT level, hyperfibrinogenemia, high D-dimer level and increased FDP level may function as hemostasis markers that predict overall survival in operable patients with colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Clinical significance of coagulation factors in operable colorectal cancer

Lee

Huh

et al. 2017

Oncology Letters

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“…However, it is clear that the ability of these conventional risk factors to predict recurrence and estimate survival is insufficient. Clinical outcomes of patients with EC are influenced not only by cancer-related risk factors, but also by host-related risk factors including white blood cells (WBCs) 11 , monocyte counts 12 , hemoglobin concentration 13 , platelet counts 14 , the neutrophil-lymphocyte ratio (NLR) 15 - 17 , and the platelet-lymphocyte ratio (PLR) 15 , 17 .…”

Section: Introductionmentioning

confidence: 99%

The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Endometrial Cancer

Eo¹,

Kwon²,

Koh³

et al. 2016

J. Cancer

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Objective: We assessed the prognostic implications of preoperative lymphocyte-monocyte ratio (LMR) in patients with endometrial cancer (EC).Methods: We retrospectively examined the LMR as a prognostic variable in a cohort of 255 patients with EC who underwent surgical resection. Patients were categorized into two groups according to the LMR (LMR-low and LMR-high) using cutoff points determined by receiving operator characteristic (ROC) curve analysis. The primary objective was to correlate the LMR to clinicopathological factors; the secondary objective was to determine the survival significance of the LMR in patients with EC.Results: Using data from the entire cohort, the most discriminative LMR cutoff value selected on the ROC curve was 3.28 for both disease-free survival (DFS) and overall survival (OS). The LMR-low and LMR-high groups included 33 (12.9%) and 222 patients (87.1%), respectively. The 5-year DFS rates in the LMR-low and LMR-high groups were 64.5 and 93.9% (P < 0.0001), respectively, and the 5-year OS rates in the two groups were 76.7 and 96.5% (P < 0.0001), respectively. On multivariate analysis, we identified histologic grade, International Federation of Gynecology and Obstetrics (FIGO) stage, and LMR levels as the strongest prognostic factors affecting DFS (P = 0.0037, P < 0.0001, and P < 0.0001, respectively), and FIGO stage and the LMR as the strongest prognostic factors predicting OS (P < 0.0001 and P < 0.0001, respectively).Conclusion: The LMR is an independent prognostic factor for both DFS and OS after surgical resection, and it provides additional prognostic value beyond standard clinicopathological parameters.

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“…Számos tumortípusnál igazoltak magasabb thrombocytaszámokat, ilyenek például a vastag-és vég-béltumorok (CRC). A magasabb thrombocytaszámok-hoz jellemzően rosszabb túlélési esélyek tartoznak [10][11][12][13][14]. A tumoros betegségekhez társuló thrombocytosis diagnózisának meghatározásához az irodalomban szá-mos eltérő thrombocyta-határértéki adat található.…”

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Colorectalis daganatokban a 2-es típusú cukorbetegség és a thrombocytosis előfordulása, a túlélésre gyakorolt hatásuk, a primer tumor műtéti eltávolítása előtt és után

et al. 2018

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Bevezetés: Egyre több irodalmi adat utal a thrombocyták és a metasztatikus tumorsejtek kapcsolatára, illetve a pre-és posztoperatív thrombocytosis prediktív markerként való alkalmazhatóságára. Mind colorectalis daganatokban, mind 2-es típusú diabetesben jellemzőek a thrombocyták mennyiségi és/vagy minőségi károsodásai. 2-es típusú diabetesben a colorectalis tumorok emelkedett incidenciája ismert. Célkitűzés: Retrospektív vizsgálatunk célja a Semmelweis Egyetem II. Belgyógyászati Klinikájának Onkológiai Ambulanciáján az elmúlt három évben kezelt colorectalis tumoros betegekben a 2-es típusú diabetes gyakoriságának meghatározása, illetve a daganatos betegség felismerésekor és a primer daganat műtéti eltávolítását követően a thrombocytaszámok, valamint további laboratóriumi és anamnesztikus adatok felmérése, továbbá statisztikai modellek segítségével vizsgálni a cukorbetegség túlélést befolyásoló hatását. Módszer: 86, random kiválasztott colorectalis tumoros beteg pre-(86 fő) és posztoperatív (66 fő, műtétre alkalmas, párosított) adatait dolgoztuk fel. A betegeket legkésőbb 2017. szeptember 30-ig vagy haláluk bekövetkeztéig követtük. Eredmények: Emelkedett (400 giga/l feletti) thrombocytaszámokat figyeltünk meg a betegek 22,1%-ában (323,5 ± 128,63 giga/l, átlag ± SD), melyek a primer tumor műtéti eltávolítását követően 10,6%-ra csökkentek (χ 2 -teszt: p = 0,0351; 289,2 ± 82,45 giga/l, p = 0,0232). Az emelkedett thrombocytaszámokhoz rövidebb túlélési idők tartoztak (R: -0,35, p = 0,0085). Diabetes a betegek harmadában volt igazolható. A diabeteses és a nem diabeteses személyek vizsgált laboratóriumi paraméterei (például vérkép, vesefunkció, májenzimek) nem különböztek. A primer tumor sebészi eltávolítását követően a diabetes ötszörös kockázati tényezője a rövidebb túlélésnek (relatív kockázat: 5,1612, p = 0,0165). Az átlagos túlélési idő 30,6 ± 26,78 hónap. Következtetés: A következményes, tartósan fennálló thrombocytosis a műtét után kedvezőtlen túlélési időre utal. Megfigyeléseink alapján a colorectalis daganatok felismerésekor az emelkedett thrombocytaszám és a 2-es típusú diabetes prognosztikai markerek lehetnek. Orv Hetil. 2018; 159(19): 756-767.

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Preoperative Thrombocytosis and Poor Prognostic Factors in Endometrial Cancer

Cited by 28 publications

References 26 publications

Clinical significance of coagulation factors in operable colorectal cancer

Clinical significance of coagulation factors in operable colorectal cancer

The Lymphocyte-Monocyte Ratio Predicts Patient Survival and Aggressiveness of Endometrial Cancer

Colorectalis daganatokban a 2-es típusú cukorbetegség és a thrombocytosis előfordulása, a túlélésre gyakorolt hatásuk, a primer tumor műtéti eltávolítása előtt és után

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