Preoperative treatment with recombinant human erythropoietin or predeposit of autologous blood in women undergoing primary hip replacement

Gombotz, Hans; Gries, Manuela; Sipurzynski, Sabine; Fruhwald, Sonja; Rehak, Peter

doi:10.1034/j.1399-6576.2000.440613.x

Cited by 29 publications

(18 citation statements)

References 27 publications

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“…14,21,30,40,47,62,65 These studies revealed that the overall volume of perioperative blood loss was similar in the PANH group and the control group (WMD, 21.98 mL; 95% CI, −46.90 to 90.86 mL; P = 0.53). These results are presented in the forest plot in Figure 4.…”

Section: Volume Of Perioperative Blood Lossmentioning

confidence: 72%

“…17,30,37,41,61,62 The length of hospitalization was similar in the PANH group and the control group, and the pooled WMD value for the hospital length of stay is presented in Table 2.…”

Section: Length Of Hospitalizationmentioning

confidence: 99%

“…16,23,25,27,28,30,33,[38][39][40][41][42][43][44][45][46][47]49,50,55,[60][61][62][63]65 These 31 studies revealed that the units of perioperative allogeneic RBC transfusion was significantly decreased in the PANH groupcompared with the control group (WMD, −0.94 units; 95% CI, −1.27 to −0.61 units; P < 0.0001). The results are presented in the forest plot in Figure 3.…”

mentioning

confidence: 98%

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Preoperative Acute Normovolemic Hemodilution for Minimizing Allogeneic Blood Transfusion

Zhou¹,

Zhang

Wang

et al. 2015

Anesthesia &Amp; Analgesia

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Section: Volume Of Perioperative Blood Lossmentioning

confidence: 72%

“…17,30,37,41,61,62 The length of hospitalization was similar in the PANH group and the control group, and the pooled WMD value for the hospital length of stay is presented in Table 2.…”

Section: Length Of Hospitalizationmentioning

confidence: 99%

mentioning

confidence: 98%

See 1 more Smart Citation

Preoperative Acute Normovolemic Hemodilution for Minimizing Allogeneic Blood Transfusion

Zhou¹,

Zhang

Wang

et al. 2015

Anesthesia &Amp; Analgesia

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“…Die alleinige Verabreichung von Erythropoietin hat sich im Hinblick auf den Fremdblutverbrauch bei urologischen und orthopädischen Patienten mit niedrigen Hämoglobinausgangswerten der Eigenblutspende als ebenbürtig erwiesen, stellt aber perioperativ höhere Hä-moglobinwerte sicher [20,28,87]. Dies ist besonders bei jenen Patienten wichtig, die aufgrund kardiovaskulärer Erkrankungen einen zu starker Abfall des Hämatokrits schlecht tolerieren [18, 29, 32 23 , 51, 52].…”

Section: Erythropoietin Dieunclassified

Perioperative Anämie

Kulier¹,

Gombotz²

2001

Anaesthesist

Self Cite

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Anemia is a frequent finding, particularly in the elderly population, and usually indicative of a serious disease. The main causes of preoperative anemia are acute or chronic hemorrhage, iron deficiency, renal insufficiency, inflammatory and neoplastic diseases. A preexisting mild anemia may be enhanced or unmasked by surgically induced bleeding or repeated diagnostic phlebotomies, and by a postoperative erythropoietic dysfunction caused by the surgical trauma, irrespective of any hemorrhage. Low hemoglobin values are associated with a distinct increase of mortality and morbidity, both in the normal population and perioperatively and in the critically ill patients. The anemia-associated risk is exacerbated by preexisting cardiovascular disease, important intraoperative blood loss and advanced age. In contradiction to established therapeutical concepts, the administration of allogeneic blood beyond hemoglobin levels of 8-10 g/dl has not been found to decrease perioperative or intensive care morbidity or mortality. Rather, in addition to the inherent long-term risks of transfusions, a liberal transfusion strategy seems to increase the incidence of postoperative complications. Thus, current transfusion guidelines tend to be interpreted in an increasingly restrictive manner. Depending on the urgency of the clinical situation, the primary goal should be to diagnose and treat the underlying disease, rather than to focus on the symptom anemia. Time permitting, the patient's cardiovascular and pulmonary status should be optimized preoperatively. Furthermore, iron should be substituted to treat and prevent deficiency. Recombinant human erythropoietin has successfully been used to treat anemia of chronic renal failure and chronic disease, as well as in the perioperative and intensive care setting, and to support the efficiency of autologous programs.

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“…Eine mathematische Kalkulation über den Wert der alleinigen präoperativen Vorbehandlung mittels Erythropoietin ergab, daû dieses Verfahren bei leicht anämischen Patienten mit einem perioperativen Blutverlust von bis zu 4000 ml am effektivsten ist[13]. Dieser theoretische Berechnung konnte auch in klinischen Studien sowohl in alleiniger Anwendung als auch in Vergleichstudien an urologischen und orthopädischen Patienten bestätigt werden[12,14,15].Carson JL, Duff A, Poses RM, Berlin JA, Spence RK, Trout R, et al: Effect of anaemia and cardiovascular disease on surgical mortality and morbidity. Lancet 1996; 348 (9034): 1055 ± 1060 2 Carson JL, Duff A, Berlin JA, Lawrence VA, Poses RM, Huber EC, et al: Perioperative blood transfusion and postoperative mortality.…”

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Perspektiven der autologen Transfusion aus transfusions-medizinischer Sicht

Eckstein¹,

Weisbach²

2004

Anästhesiol Intensivmed Notfallmed Schmerzther

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Preoperative treatment with recombinant human erythropoietin or predeposit of autologous blood in women undergoing primary hip replacement

Cited by 29 publications

References 27 publications

Preoperative Acute Normovolemic Hemodilution for Minimizing Allogeneic Blood Transfusion

Preoperative Acute Normovolemic Hemodilution for Minimizing Allogeneic Blood Transfusion

Perioperative Anämie

Perspektiven der autologen Transfusion aus transfusions-medizinischer Sicht

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