Preoperatively elevated RDW-SD and RDW-CV predict favorable survival in intrahepatic cholangiocarcinoma patients after curative resection

Li, Xingchen; Chen, Qichen; Bi, Xinyu; Zhao, Jianjun; Li, Zhiyu; Zhou, Jianguo; Huang, Zhen; Zhang, Yefan; Mao, Rui; Zhao, Hong; Cai, Jianqiang

doi:10.1186/s12893-021-01094-6

Cited by 15 publications

(7 citation statements)

References 40 publications

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“…In a research on intrahepatic cholangiocarcinoma, patients with low levels of RDW were more likely to be with poor survival after curative resection. 27 Another research in Turkey found that in most patients with chronic obstructive pulmonary disease (COPD) exacerbations, the values of RDW were under the normal range and lower RDW was associated with disease severity. 28 It could be partly explained by the differences in the general characteristics between the cohorts in different studies.…”

Section: Discussionmentioning

confidence: 99%

“…However, few studies concluded that lower RDW was associated with worse outcomes in some diseases. In a research on intrahepatic cholangiocarcinoma, patients with low levels of RDW were more likely to be with poor survival after curative resection 27 . Another research in Turkey found that in most patients with chronic obstructive pulmonary disease (COPD) exacerbations, the values of RDW were under the normal range and lower RDW was associated with disease severity 28 .…”

Section: Discussionmentioning

confidence: 99%

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Red cell distribution width and in‐hospital mortality in septic shock: A public database research

Ding

et al. 2022

Int J Lab Hematology

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Objective: This study aimed to explore the relationship between red cell distribution width (RDW) and in-hospital mortality in septic shock based on a large-scale public database.Methods: All patients with septic shock in MIMIC-IV were enrolled. Based on RDW values, the general characteristics of different groups were compared. Different models were constructed for exploring the association of RDW and in-hospital mortality. To assess the predictive value of RDW, receiver operator characteristic (ROC) curve analysis was applied.Results: A total of 3006 patients with septic shock were included and in-hospital mortality was 32.27% (n = 970). The results of the fully adjusted model demonstrated that RDW was positively associated with in-hospital mortality in septic shock patients after adjusting all confounders (OR = 1.12, 95% CI:1.08-1.17, p < .001). A linear relationship between RDW and in-hospital mortality was found. For predicting in-hospital mortality, the area under the ROC curve (AUC) of RDW was .602 and the best threshold of RDW was 17.25%. Conclusion:RDW was associated with in-hospital mortality in septic shock. It could be a useful marker for predicting clinical outcomes in septic shock.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Red cell distribution width and in‐hospital mortality in septic shock: A public database research

Ding

et al. 2022

Int J Lab Hematology

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“…RDW is a routine complete blood count parameter that evaluates the variability in the size of erythrocytes in circulation. It is usually expressed as RDW-CV and RDW-SD, which is less influenced by other factors than the former [ 12 , 13 ]. In the last few years, numerous studies have consistently confirmed RDW-CV as a tool for the differential diagnosis of anemia.…”

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width-standard deviation but not red blood cell distribution width-coefficient of variation as a potential index for the diagnosis of iron-deficiency anemia in mid-pregnancy women

et al. 2021

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The aim of this study was to compare the diagnostic values of red blood cell distribution width-coefficient of variation (RDW-CV) and red blood cell distribution width-standard deviation (RDW-SD) in mid-pregnancy women with iron deficiency anemia (IDA). To obtain the results, 115 mid-pregnancy women with IDA, defined as the IDA group, and 142 healthy mid-pregnancy women, selected as the control group, were enrolled in this study. Hematological parameters and ferritin concentrations in the serum were analyzed. The efficiency of RDW-CV and RDW-SD to distinguish IDA from mid-pregnancy women was evaluated using receiver operating characteristic (ROC) curves. The RDW-SD value in the IDA group was significantly higher than that in the control group (p < 0.05), while the RDW-CV value did not differ between them (p = 0.84). Significantly negative correlations were found between RDW-CV (r = −0.297, p = 0.001), RDW-SD (r = −0.404, p = 0.000), and serum ferritin in the IDA group but not in the control group. For the diagnosis of IDA, RDW-CV and RDW-SD produced areas under the ROC curves of 0.58 and 0.84. To conclude, our results suggest that RDW-SD, but not RDW-CV, can be used as a diagnostic index of IDA for mid-pregnancy women.

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“…RDW mainly reacts to the coefficient of variation of red blood cells and is affected by chronic inflammation, oxidative stress, nutrient deficiency, and other factors. RBC distribution width is now widely used for the prognostic diagnosis of COPD, 13 bile duct surgery, 14 and chronic heart failure 15 . In this study, we retrospectively analysed plasma procalcitonin concentration and red blood cell distribution width at admission to improve the diagnostic value for prognosis in severely burned patients.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of procalcitonin and red blood cell distribution width at admission on the prognosis of patients with severe burns: A retrospective analysis

Tang

Qiu

Wang

et al. 2023

International Wound Journal

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The plasma procalcitonin (PCT) concentration and red blood cell distribution (RDW) value after severe burns can be used as prognostic indicators, but at present, it is difficult to give consideration to sensitivity and specificity in diagnosing the prognosis of severe burns with a single indicator. This study analysed the diagnostic value of plasma PCT concentration and RDW value at admission on the prognosis of severe burn patients to improve its sensitivity and specificity. A total of 205 patients with severe burns who were treated in the First Affiliated Hospital of Anhui Medical University from November 2017 to November 2022 were retrospectively analysed. The optimal cut‐off values of plasma PCT concentration and RDW were analysed and counted through the subject curve (ROC curve). According to the cut‐off value, patients were divided into high PCT group and low PCT group, high RDW group and low RDW group. The independent risk factors of severe burns were analysed by single‐factor and multiple‐factor COX regression. Kaplan–Meier survival was used to analyse the mortality of high PCT group and low PCT group, high RDW group and low RDW group. The area under the curve of plasma PCT concentration and RDW value at admission was 0.761 (95% CI, 0.662–0.860, P < .001), 0.687 (95% CI, 0.554–0.820, P = .003) respectively, and the optimal cut‐off values of serum PCT concentration and RDW were 2.775 ng/mL and 14.55% respectively. Cox regression analysis found that age, TBSA, and RDW were independent risk factors for mortality within 90 days after severe burns. Kaplan–Meier survival analysis showed that there was a significant difference in the 90‐day mortality rate of severe burns between the PCT ≥ 2.775 ng/mL group and the PCT < 2.775 ng/mL group (log‐rank: 24.162; P < .001), with the mortality rate of 36.84% versus 5.49%, respectively. The 90‐day mortality rate of severe burns was significantly different between the RDW ≥ 14.55% group and the RDW < 14.55% group (log‐rank: 14.404; P < .001), with the mortality rate of 44% versus 12.2% respectively. The plasma PCT concentration and RDW value at admission are both of diagnostic value for the 90‐day mortality of severe burns, but the plasma PCT concentration has higher sensitivity and the RDW value has higher specificity. Age, TBSA, and RDW were independent risk factors for severe burns, and then plasma PCT concentration was not independent risk factors.

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Preoperatively elevated RDW-SD and RDW-CV predict favorable survival in intrahepatic cholangiocarcinoma patients after curative resection

Cited by 15 publications

References 40 publications

Red cell distribution width and in‐hospital mortality in septic shock: A public database research

Red cell distribution width and in‐hospital mortality in septic shock: A public database research

Red blood cell distribution width-standard deviation but not red blood cell distribution width-coefficient of variation as a potential index for the diagnosis of iron-deficiency anemia in mid-pregnancy women

Diagnostic value of procalcitonin and red blood cell distribution width at admission on the prognosis of patients with severe burns: A retrospective analysis

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