Preparasi dan Karakteristik Floating Tablet Ekstrak Daun Jambu Biji (Psidium guajava L.) dengan Variasi Kombinasi Xanthan Gum dan HPMC

Andini, Septia; Sa’diah, Siti; Puspa, Suci

doi:10.25026/jsk.v4i4.1226

Cited by 1 publication

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This layer of gel formed can serve as a physical barrier for drug release from the matrix. 44 Andini et al determined the total floating time of a tablet by inserting a floating tablet formulated in a beaker glass containing 100 mL of 0.1 N HCl. c. 44 High-viscosity polymers such as K100M are used for long floating time.…”

Section: Floating Lag Timementioning

confidence: 99%

See 1 more Smart Citation

The Use of Natural and Synthetic Polymers in the Formulation of Gastro retentive Drug Delivery System

Ainurofi¹,

Daryati²,

Murtadla³

et al. 2023

IJDDT

View full text Add to dashboard Cite

The gastric emptying process drastically reduces the bioavailability of drugs that target the stomach for their action. A gastro retentive drug delivery system (GRDDS) becomes a solution to retain drugs in the stomach and release drugs from the formulation system within a certain period. The polymer used in the GRDDS formulation is the essential excipient that can retain the drugs in the stomach. Several ways for GRDDS to maintain its existence in the stomach are using some systems, such as mucoadhesive, low-density, high-density, swellable, eff ervescent, and expandable systems. A polymer is a macromolecular substance with a long repeating chain consisting of natural and synthetic polymers, each with diff erent potentials. It is considered for its ability to regulate drug release, good fl ow properties, can improve drug dissolution to improve bioavailability and stability during processing in the body. Combining natural and synthetic polymers is often carried out to obtain advantages and cover the existing polymer’s disadvantages. Polymers can release drugs using three diff erent mechanisms, i.e., diff usion, degradation, and expansion. These techniques are often chosen for the formulation of GRDDS because of their more fl exible system and fi t for almost all types of GRDDS. The polymer used in the GRDDS system is chosen from its physicochemical properties and the number of fl oating times, drug release rate, viscosity, fl oating lag times, bioavailability, and solubility.

show abstract

Section: Floating Lag Timementioning

confidence: 99%

“…44 Andini et al determined the total floating time of a tablet by inserting a floating tablet formulated in a beaker glass containing 100 mL of 0.1 N HCl. c. 44 High-viscosity polymers such as K100M are used for long floating time. 45 The required floating time is at least 12 hours.…”

Section: Floating Lag Timementioning

confidence: 99%