Preparation and anti-inflammatory activity of anilides of indolecarboxylic acids and their homologs

Newer Indolyl Imidazolones as Anti-Inflammatory Agents

“…Further more, active compounds of the series were also screened for their analgesic activity against aconitine-induced writhing in albino mice. The toxicity of the compounds was reflected by their approximate LD5q values.Various indole derivatives constitute an important group of non-steroidal anti-in flammatory agents [8], This is supported by the fact that the discovery of indomethacin [9] has created a landmark among the non steroidal synthetic derivatives which is being used clinically for the treatment of various types of inflammatory disorders. Further more, many imidazole derivatives [6] have also been reported as potent anti-inflamma tory agents.…”