Preparation and anti-tumor activity of selenium nanoparticles based on a polysaccharide from Paeonia lactiflora

Wang, Xuelian; Liu, Wenhui; Li, Yeling; Ma, Lingling; Lin, Zhen; Xu, Jing; Guo, Yuanqiang

doi:10.1016/j.ijbiomac.2023.123261

Cited by 34 publications

(4 citation statements)

References 66 publications

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“…Using GLSO with antioxidant activity and nanoselenium as the active components, we designed and synthesized a GLSO@SeNP hydrogel composite system through emulsion preparation, high-pressure homogenization, and other technologies, differing from previously reported studies on NPs [ 41 , 42 , 43 ]. In the present study, NPs of the same system were simultaneously compared.…”

Section: Discussionmentioning

confidence: 99%

Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways

et al. 2023

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Oxidative stress damage of pancreatic β-cells is a key link in the pathogenesis of type 2 diabetes mellitus. A long-term increase of free fatty acids induces the increase of reactive oxygen species (ROS) in β-cells, leading to apoptosis and dysfunction of β-cells. Ganoderma lucidum spore oil (GLSO) is a functional food complex with strong antioxidant activity, but its solubility and stability are poor. In the present study, GLSO-functionalized selenium nanoparticles (GLSO@SeNPs) with high stability and uniform particle size were synthesized by a high-pressure homogeneous emulsification method. The aim of this study was to investigate the protective effects of GLSO@SeNPs on INS-1E rat insulinoma β-cells against palmitic-acid (PA)-induced cell death, as well as the underlying mechanisms. Our results showed that GLSO@SeNPs had good stability and biocompatibility, and they significantly inhibited the PA-induced apoptosis of INS-1E pancreatic cells by regulating the activity of related antioxidant enzymes, including thioredoxin reductase (TrxR), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px). Western blot analysis showed that GLSO@SeNPs reversed the PA-induced changes in MAPK pathway protein expression levels. Thus, the present findings provided a new theoretical basis for utilizing GLSO@SeNPs as a treatment for type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways

et al. 2023

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“…Biogenic SeNPs prepared using Crataegus monogyna extracts and Lactobacillus casei showed anticancer activity against MCF-7 breast adenocarcinoma cells [53,54]. The anticancer efficacy of SeNPs may be due to their ability to induce apoptosis in cancer cells, which causes cell degeneration and eventual cell death [55,56]. So, the observed morphological alterations in cells treated with SeNPs may potentially be attributed to the induction of apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Biogenic Selenium Nanoparticles: Anticancer, Antimicrobial, Insecticidal Properties and Their Impact on Soybean (Glycine max L.) Seed Germination and Seedling Growth

Abdelsalam,

El-Sayed,

Hamama

et al. 2023

Biology

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Selenium nanoparticles (SeNPs) have demonstrated significant potential in a variety of disciplines, making them an extremely desirable subject of research. This study investigated the anticancer and antibacterial properties of my-co-fabricated selenium SeNPs, as well as their effects on soybean (Glycine max L.) seeds, seedling growth, cotton leafworm (Spodoptera littoralis) combat, and plant pathogenic fungi inhibition. SeNPs showed anticancer activity with an IC50 value of 1.95 µg/mL against MCF-7 breast adenocarcinoma cells. The myco-synthesized SeNPs exhibited an antibacterial effect against Proteus mirabilis and Klebsiella pneumoniae at 20 mg/mL. The use of 1 µM SeNPs improved soybean seed germination (93%), germination energy (76.5%), germination rate (19.0), and mean germination time (4.3 days). At 0.5 and 1.0 µM SeNPs, the growth parameters of seedlings improved. SeNPs increased the 4th instar larval mortality of cotton leafworm compared to control, with a median lethal concentration of 23.08 mg/mL. They inhibited the growth of Fusarium oxysporum, Rhizoctonia solani, and Fusarium solani. These findings demonstrate that biogenic SeNPs represent a promising approach to achieving sustainable progress in the fields of agriculture, cancer therapy, and infection control.

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“…Typically, the polysaccharides extracted from different plant spp. may be contaminated with proteins, lipids, and various other impurities, resulting in a heterogeneous distribution of sugar composition in the obtained polysaccharides ( 50 , 51 ). Proteins, as the complex biomolecules, are commonly covalently or non-covalently associated with polysaccharides in Russula , thereby forming protein-polysaccharide complexes that might hinder their accurate characterization and potential application ( 52 , 53 ).…”

Section: Purification Of Polysaccharides From Russulamentioning

confidence: 99%

Polysaccharides from Russula: a review on extraction, purification, and bioactivities

Cheng,

Gan,

Yan

et al. 2024

Front. Nutr.

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Russula, a renowned edible fungus, has gained popularity as a functional food among diverse populations due to the abundant presence of amino acids, proteins, and polysaccharides. As the primary constituents of Russula, polysaccharides exhibit a wide range of biological properties, making them an exceptional choice for incorporation into food, medicines, and diverse biotechnological applications. This review provides a summary of the recent research on the extraction, purification, and biological applications of polysaccharides from various Russula spp. Currently, there are many advanced extraction technologies, such as hot water-based extraction, alkali-based extraction, ultrasonic-assisted extraction and microwave-assisted extraction. Hence, the latest progress of extraction technologies, as well as their advantages and limitations will be discusses and summarizes in this review. The separation and purification methods of polysaccharide from Russula were introduced, including ethanol precipitation, deproteinization and gel filtration chromatography. It also focuses on exploring the diverse bioactive capabilities of Russula, including anti-oxidant, anti-tumor, immunomodulatory, anti-inflammation, and anti-bacterial properties. Hence, this review aims to foster a comprehensive understanding of the polysaccharides from various Russula spp. and pave the way for their promising and potential future applications in the medical and functional fields.

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Preparation and anti-tumor activity of selenium nanoparticles based on a polysaccharide from Paeonia lactiflora

Cited by 34 publications

References 66 publications

Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways

Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways

Biogenic Selenium Nanoparticles: Anticancer, Antimicrobial, Insecticidal Properties and Their Impact on Soybean (Glycine max L.) Seed Germination and Seedling Growth

Polysaccharides from Russula: a review on extraction, purification, and bioactivities

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